Author: Jinfiniti Science

Choosing a High Quality Turmeric Supplement: Buyer’s Guide

Written by Jinfiniti Science on November 19, 2024. Posted in Turmeric/Curcumin. No Comments on Choosing a High Quality Turmeric Supplement: Buyer’s Guide

Your turmeric supplement could be a waste of money.

Harsh? Perhaps. But here’s the truth: not all turmeric supplements are created equal. In fact, many popular brands contain such low-quality ingredients that your body can barely absorb them.

For over 4,000 years, turmeric has been revered in traditional medicine. Today, modern science confirms what ancient healers knew all along – this golden spice packs serious health-promoting power.

But here’s the catch.

As turmeric supplements flood the market, consumers face a bewildering array of choices. Confusing labels. Misleading claims. And prices that range from suspiciously cheap to eye-wateringly expensive.

How do you cut through the noise and find a supplement that actually works?

In this curcumin extract buying guide, you’ll discover:

The common red flags that leave you with an ineffective or, worse, harmful supplement – and how to avoid them.
The four critical factors that separate premium turmeric supplements from worthless pills.
The exact combination of ingredients, dosages, and extraction methods that maximize absorption and effectiveness.
The most bioavailable turmeric supplement on the market.

Health Benefits of Turmeric and Curcumin

Ever wondered why turmeric has a golden color? The same compounds responsible for that vibrant hue also deliver powerful health benefits.

Turmeric root contains a family of active compounds called curcuminoids. The star of the show? Curcumin. This remarkable compound makes up about 2-5% of turmeric and acts as a potent antioxidant and anti-inflammatory agent.

Modern science has extensively studied curcumin’s effects on health. Here’s what the research reveals:

Curcumin targets multiple steps in the inflammatory pathway and matches the effectiveness of some anti-inflammatory drugs – without the harsh side effects¹.
Clinical trials have demonstrated curcumin’s ability to reduce joint tenderness, improve flexibility, decrease inflammatory markers and support cartilage health².
Curcumin can cross the blood-brain barrier, increase BDNF (brain-derived neurotrophic factor)³, support memory and focus, and help maintain cognitive function with age⁴.
Curcumin supports healthy blood pressure⁵, improves blood vessel function⁶, and maintains healthy cholesterol levels⁷.
Curcumin neutralizes harmful free radicals, boosts your body’s own antioxidant enzymes and helps protect cells from oxidative stress⁸.

However, your kitchen turmeric and a high-quality supplement are worlds apart. The powdered turmeric you find on most grocery shelves contains just 2-5% curcumin with poor absorption rates by the body, requiring large amounts for therapeutic effects, making it best suited for adding flavor to food.

What’s more, curcumin is notoriously difficult for your body to absorb. In fact, studies show that plain curcumin gets metabolized and eliminated before it can deliver its benefits.

Hence the importance of choosing turmeric supplements that maximize the absorption of curcumin.

Red Flags When Buying Turmeric Supplements

The truth about turmeric supplements lies in the details. Here are the top warning signs to watch for that signal poor quality and potentially misleading products.

The Mystery of “Proprietary Blends”

When you see “proprietary blend” on a label, proceed with caution. Here’s why:

Manufacturers don’t disclose individual ingredient amounts
You can’t verify if you’re getting therapeutic doses
The first ingredient might be present in meaningful amounts, but the rest could be mere sprinkles
It’s often a tactic to hide low doses of expensive ingredients

What to Do Instead: Look for supplements that clearly list the amount of each ingredient, especially the curcuminoid content.

Suspiciously Low Prices

That bargain-bin turmeric supplement? It’s probably too good to be true. Quality turmeric supplements are expensive to produce because they require:

High-grade raw materials
Standardized extraction processes
Third-party testing
Quality control measures

If a month’s supply costs less than $20, question what corners were cut to achieve that price.

Industry Insight: High-quality turmeric extract with 95% curcuminoids is expensive to produce. When you factor in other active ingredients and production costs, extremely low prices simply don’t add up.

Missing or Vague Standardization Information

Quality supplements proudly display their standardization percentages. Red flags include:

No mention of curcuminoid percentage
Unclear extract ratios
Missing potency information
Vague terms like “high-strength” without specifics

What to Look For: Clear statements like “standardized to 95% curcuminoids” or “contains 1000mg of turmeric extract (95% curcuminoids).”

The Filler Trap

Check the “Other Ingredients” section carefully. Avoid supplements loaded with:

Artificial colors
Chemical preservatives
Unnecessary binding agents
Cheap bulking agents like maltodextrin
Silicon dioxide in large amounts

Best Practice: Look for products with minimal necessary ingredients and vegetable-based capsules.

What to Look For When Choosing a Turmeric Supplement

Choosing the right curcumin supplement doesn’t have to be complicated. Armed with the right knowledge, you can quickly identify high-quality products that deliver real results.

Here are the three essential factors that separate premium supplements from ineffective ones.

Curcuminoid Content

A high-quality turmeric supplement should contain extract standardized to 95% curcuminoids, with the amount clearly stated on the label. Research shows this concentration provides the most powerful anti-inflammatory and antioxidant benefits.

Bioavailability Enhancers

Even the highest-quality curcumin is useless if your body can’t absorb it. That’s why leading supplements include bioavailability enhancers like black pepper extract (standardized to 95% piperine), which can increase absorption by up to 2000%⁹.

Dosage Considerations

Research indicates that the sweet spot for turmeric supplementation is 1000-1500mg of standardized extract per day, typically divided into 1-2 doses. More isn’t necessarily better – studies show that doses above 2000mg per day don’t provide additional benefits and may increase the risk of mild side effects.

A high-quality turmeric supplement should check all these boxes:

✓ 95% standardized curcuminoid extract

✓ Bioavailability enhancers included

✓ 1000-1500mg daily dose

✓ Clear labeling of all ingredients

The Best Turmeric Supplement: Extra Strength Turmeric+ Formula

After examining countless turmeric supplements on the market, we found most fall short in either potency, absorption, or synergistic support. That’s why we developed our Extra Strength Turmeric+ curcumin supplement, a premium formula that combines clinical-grade turmeric with proven synergistic ingredients.

Each daily serving of Extra Strength Turmeric+ delivers:

Maximum-Strength Turmeric Extract (1000mg)

Standardized to 95% curcuminoids
Highest purity available
Clinically-validated dosage
Premium extraction process

Strategic Absorption Enhancement

Black Pepper Extract (30mg, standardized to 95% piperine) ensures maximum bioavailability. Studies show this critical addition can increase curcumin absorption by up to 2000%.

Synergistic Anti-Inflammatory Support

Our formula amplifies turmeric’s benefits with a targeted blend of complementary ingredients:

Boswellia Extract (200mg, >65% Boswellic Acid)

Works through different inflammatory pathways than curcumin
Enhances joint comfort and mobility
Provides sustained anti-inflammatory support

Ginger Root Extract (4:1) (200mg, 10% Gingerols)

Complements turmeric’s anti-inflammatory effects
Supports digestive health
Enhances overall absorption

Quercetin (70mg, 95% Purity)

Powerful antioxidant support
Enhances the effects of other botanicals
Supports cellular health

Why Our Formula Works Better

Most turmeric supplements stop at basic ingredients. Extra Strength Turmeric+ takes a different approach:

Multiple Action Pathways: Our ingredients work through different mechanisms, providing comprehensive inflammatory support.
Enhanced Absorption: Each compound is delivered in its most bioavailable form, ensuring maximum uptake.
Optimal Dosing: Every ingredient is included at its clinically-validated dose – no cutting corners.
Quality Assurance: Produced at a GMP-certified manufacturing facility, ensuring quality, safety and consistency.

DISCOVER TURMERIC+

Turmeric Extract FAQs

What is the Bioavailability of Curcumin?

Raw curcumin has naturally low bioavailability (around 3-8%), meaning only a small portion gets absorbed into your bloodstream when consumed alone.

Does Black Pepper Extract Increase Turmeric Bioavailability?

Piperine, the active compound in black pepper, can enhance curcumin absorption by up to 2000% by inhibiting liver enzymes that would normally break it down.

What Form of Curcumin is Best?

Curcumin formulated with black pepper extract (BioPerine) is considered the most effective form, as it significantly improves absorption compared to standard supplements.

When is the Best Time to Take Curcumin?

For optimal absorption, take curcumin supplements with a meal containing healthy fats, as curcumin is fat-soluble and needs dietary fat to be properly absorbed.

How Does Curcumin Help with Inflammation?

Curcumin works by blocking key inflammatory molecules like NF-kB and COX-2, while also acting as a powerful antioxidant that neutralizes free radicals in the body.

Referenced Sources:

What is NAD+ and What Does It Do For Cellular Health?

Written by Jinfiniti Science on November 15, 2024. Posted in NAD, NAD+, Premature Aging. No Comments on What is NAD+ and What Does It Do For Cellular Health?

In the world of health and longevity, there’s one molecule that’s been making waves for its important role in cellular health: NAD+. Short for Nicotinamide Adenine Dinucleotide, NAD+ is a coenzyme present in every cell of our body, and it’s often called a “helper molecule” for good reason.

It helps in converting the food we eat into energy and supports vital functions like repairing damaged DNA. However, as we age, our natural NAD+ levels start to decline, which can affect everything from metabolism and energy to our cells’ ability to repair themselves.

This drop in NAD+ is linked to a range of age-related issues, including lower energy, slower metabolism, and an increased risk of chronic diseases.

So, what exactly does NAD+ do for our cells, and why is it essential for staying healthy as we get older?

In this article, we discuss…

The critical role of NAD+ in maintaining cellular health
What happens when your NAD+ takes a dive (and why it matters)
Effective ways to supercharge your NAD+ levels for peak performance and longevity

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a molecule that drives hundreds of critical metabolic processes inside our cells, acting as a cellular energy shuttle. First discovered in 1906 by scientists studying fermentation in yeast, NAD+ isn’t just another biochemical compound.

It’s a direct participant in cellular energy production, moving electrons and triggering repair signals. When you consume food, NAD+ helps break down nutrients and convert them into usable cellular energy.

Picture your cells as intricate machines. NAD+ serves as both the fuel line and the maintenance crew, making sure everything operates as efficiently as possible. It shuttles electrons during metabolic reactions and alerts cellular systems when something needs fixing.

Here’s where things get interesting – and a bit frustrating. As we age, our NAD+ levels take a nosedive, typically dropping by half between our 20s and 80s. It’s one of biology’s cruel jokes: just when we need cellular efficiency the most, our NAD+ supply starts dwindling.

The science behind this decline is pretty fascinating. Your cells face a double setback: they start producing less NAD+ while simultaneously using more of it to repair accumulated damage. It’s like trying to feed a growing family with a garden that keeps shrinking.

Thankfully, your body has multiple ways to make NAD+. It can be created from tryptophan (yes, the amino acid in turkey), from vitamin B3, or by recycling existing NAD+ molecules. This versatility has sparked intense research interest, with scientists discovering that NAD+ is involved in over 500 different cellular reactions – quite a resume for one tiny molecule!

This has led to exciting developments in aging research, including promising approaches using precursor molecules like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Understanding how to maintain healthy NAD+ levels through various pathways could be one of the keys to healthier aging.

The Discovery of NAD+

The story of NAD+ began in a humble laboratory in 1906, when two British biochemists made a puzzling observation while studying yeast. Sir Arthur Harden and William John Young noticed something extraordinary: when they added boiled yeast extract to fresh yeast, the fermentation process unexpectedly accelerated. The mysterious compound they had stumbled upon, which they dubbed “cozymase,” would later become known as NAD+ (Nicotinamide Adenine Dinucleotide).

The scientific community quickly recognized the magnitude of this finding, and researchers around the world began unraveling the secrets of the molecule. Hans von Euler-Chelpin made significant strides in the 1920s and 1930s, mapping out NAD+’s chemical structure and identifying its key components – sugar, adenine, and phosphate. His groundbreaking work, along with Harden’s initial discovery, earned them both the 1929 Nobel Prize in Chemistry. The breakthrough continued when Otto Heinrich Warburg discovered in 1936 that NAD+ contained a special pyridine ring that could transfer hydrogen atoms, explaining how it helped cells transform nutrients into energy.

As research techniques improved, scientists gradually mapped out NAD+’s complete structure and began to understand its true importance in the cell. What started as a curious observation about yeast fermentation led to one of biochemistry’s most crucial discoveries. NAD+ turned out to be essential not just for fermentation, but for DNA repair, gene expression, and cellular communication – making it a fundamental molecule for life itself.

What’s the Purpose of NAD+ in the Human Body?

NAD+ switches between two states: NAD+ (oxidized) and NADH (reduced). This molecular switch enables core cell operations like energy production, DNA maintenance, and cell communication.

As an electron carrier, NAD+ moves electrons during metabolism. When reduced to NADH, it delivers electrons to the transport chain that generates ATP – the basic fuel cells need. The continuous conversion between NAD+ and NADH maintains energy flow through major pathways like glycolysis and the citric acid cycle¹.

NAD+ supplies key materials to DNA repair enzymes called PARPs². When NAD+ runs low, DNA damage builds up, which can raise the risk of cancer. Research shows that higher NAD+ levels strengthen DNA protection³.

Through its influence on sirtuins, NAD+ regulates how genes turn on and off by modifying chromatin proteins.⁴ This shapes aging patterns and metabolic function.

NAD+ also helps create signaling molecules like cyclic ADP-ribose (cADPR) that coordinate calcium movement and other essential cell activities.

Put simply, NAD+ supports energy production, DNA repair, gene regulation, and cellular signaling. Maintaining healthy levels of NAD+ is instrumental for cellular health and resilience, helping us achieve better health and longevity.

What Happens If You Have Low NAD+?

Since NAD+ is involved in processes like energy production, DNA repair, and cellular signaling, low levels can disrupt these vital functions and lead to symptoms of NAD+ deficiency, as well as a range of health issues affecting metabolism, brain function, and heart health.

When it comes to metabolic disorders, declining NAD+ levels are linked to issues with glucose and lipid metabolism. This can result in insulin resistance⁵, a major factor in metabolic syndrome—a condition characterized by obesity, high blood pressure, and abnormal cholesterol levels. Research published in Frontiers in Endocrinology found that people with lower NAD+ levels had a higher prevalence of metabolic diseases, including hypertension and diabetes⁶.

NAD+ also supports brain health by maintaining the energy production and DNA repair mechanisms that support neurons. In conditions like Alzheimer’s and Parkinson’s diseases, NAD+ levels are often lower, which may accelerate neurodegeneration⁷.

Low NAD+ levels can also negatively impact heart health. The heart requires a lot of energy to function, and NAD+ is essential for maintaining efficient energy production.

Reduced NAD+ levels can impair mitochondrial function, leading to lower ATP production and a higher risk of heart failure. This has been supported by a study published in the Frontiers in Physiology, where researchers discovered that NAD+ metabolism disruptions are closely linked to cardiovascular conditions, such as ischemic heart disease and heart failure⁸.

Ultimately, low NAD+ levels can have wide-reaching effects on metabolism, brain function, and cardiovascular health. But through optimizing your NAD levels, you can prevent or manage these issues for better health outcomes.

Benefits of NAD+ for Cellular Health

Beyond its all-important role in energy production, NAD+ offers a remarkable array of benefits for cellular health that make it indispensable for optimal functioning.

One of its most significant advantages is its ability to activate enzymes called sirtuins, which act as cellular stress sensors⁹. When activated by NAD+, these sirtuins help cells adapt to various forms of stress, from metabolic fluctuations to environmental challenges, essentially functioning as cellular guardians that promote resilience and longevity.

The health benefits of NAD+ also include maintaining robust cellular communication networks, particularly through a process called ADP-ribosylation. This process helps cells respond appropriately to damage or stress signals, ensuring they can coordinate their responses effectively.

We can think of NAD+ as a cellular emergency response system. When one part of the cell detects a problem, NAD dependent signaling helps mobilize the appropriate repair mechanisms, maintaining cellular health and preventing potential dysfunction.

In essence, the importance of NAD cannot be overstated for sustaining cellular vitality, promoting healthy aging, and improving our overall quality of life as we grow older. It’s not just about energy, but about thriving as you age.

Can NAD+ Truly Slow Aging?

If you’re hoping to feel younger and stay healthy as you age, boosting your NAD+ levels might be the answer. NAD+ has become a buzzword in anti-aging research, with growing evidence suggesting it can help slow down the aging process by improving cellular health.

For example, research published in Frontiers in Aging found that supplementing with NMN (a precursor to NAD+) can improve energy levels and insulin sensitivity, both crucial for healthy aging¹⁰.

In this 60-day study, participants took 300 mg of NMN daily, leading to an impressive 38% increase in NAD+/NADH levels by day 60. Meanwhile, those on a placebo saw minimal changes. The NMN group also reported better quality of life and stable insulin sensitivity, while the placebo group experienced declines. This shows that NMN can effectively boost NAD+ levels, improve energy, and support better metabolic health.

Another study in Nature Communications looked at nicotinamide riboside (NR), another NAD+ booster. Participants took 500 mg twice daily for six weeks. The results showed a significant increase in NAD+ levels, improving several metabolic health markers. Although major changes like blood pressure were not observed, the rise in NAD+ suggests that it could help enhance overall cellular function¹¹.

A long-term study published in Scientific Reports explored how NMN impacts cardiovascular health in older adults¹². For 12 weeks, participants took 250 mg of NMN daily. While their blood pressure didn’t change much, there was a positive trend toward reducing arterial stiffness, a sign of better cardiovascular health. This suggests NMN might help support heart health as we get older.

These findings suggest that keeping your NAD+ levels up could help slow the progress of age-related diseases. It not only helps boost energy and improve metabolism but also supports healthy blood sugar levels and may even protect your heart.

Replenishing NAD+ Levels in Your Body

Supporting your NAD+ levels helps maintain cell health and can slow down signs of aging. While lifestyle changes like regular exercise, calorie restriction, and consuming foods high in NAD precursors can support the body’s NAD+ production, their impact often diminishes as we get older.

Opting for a more targeted approach—combining NAD+ testing with strategic supplementation of NAD precursors—can be much more effective to naturally increase NAD levels.

The truth is, there isn’t a one-size-fits-all approach to optimizing NAD+ levels, so the first step is to assess where your levels currently stand — are they lower than they should be, at baseline, or optimized?

Knowing this will help you determine the right dosage of NAD+ supplementation for your needs.

An Intracellular NAD+ test serves as an effective diagnostic tool in this context. Testing your NAD+ levels is the most effective way to figure out the optimal dosage for you.

Ideally, you should measure both at baseline and after supplementation. At a minimum, testing after supplementation is essential, as the same dosage may work differently for different people—it could be optimal, ineffective, or even toxic. An NAD+ test provides you with actionable data to help you optimize both your NAD+ levels and your overall health.

If you’re already taking NAD+ supplements, using NAD+ IV infusions, injections, or patches, it’s crucial to test your levels to ensure these products are actually working. Many products on the market don’t deliver the desired results, or they don’t work as effectively as they claim.

For optimal NAD+ enhancement, our Vitality ↑® NAD+ Booster delivers a clinically validated formulation that combines key NAD precursor NMN with Creatine monohydrate, D-ribose, and Nicotinamide. This synergistic blend demonstrates superior efficacy in elevating cellular NAD+ levels while promoting comprehensive cellular regeneration.

In fact, Vitality ↑® NAD+ Booster outperforms many other NAD+ precursors on the market. Almost all users with optimized NAD+ levels report noticeable improvements in their health and performance, making it an excellent choice for anyone looking to boost their NAD+ levels.

DISCOVER VITALITY ↑®

Future Directions for NAD+ Research

The future of NAD+ research is brighter than ever, with two exciting areas taking center stage: personalized NAD+ therapies and advanced monitoring techniques.

With personalized therapies, you can now customize NAD+ interventions based on your unique metabolic profile and health needs. This means you’ll receive the optimal dosage and type of NAD+ precursor tailored specifically to you, boosting the effectiveness of supplementation and enhancing cellular health.

The potential? Slowing age-related decline and improving overall vitality.

On the other hand, the development of real-time NAD+ monitoring tools is helping us better understand and manage cellular metabolism. Using genetically encoded fluorescent sensors, researchers can now track NAD+ levels dynamically within cells. This provides deeper insights into metabolic states and how cells respond to various stimuli.

At Jinfiniti, we’re proud to be at the forefront of this research with our cutting-edge Intracellular NAD test and Vitality ↑® NAD+ Booster supplement.

The Intracellular NAD test allows you to accurately measure your NAD+ levels, offering valuable insights into your metabolic health and identifying specific supplementation needs. This personalized testing approach ensures that you can effectively optimize your NAD+ levels, boosting cellular function and vitality.

Our Vitality ↑® NAD+ Booster supplement supports this process by providing key precursors to help your body naturally synthesize more NAD+.

By combining advanced testing with the Intracellular NAD test and targeted supplementation like Vitality ↑® NAD+ Booster, we’re taking a comprehensive approach to enhance cellular health and longevity. This empowers you to take control of your health and represents a major step forward in understanding how NAD+ can improve well-being as we age.

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Referenced Sources:

NAD Levels by Age Group: What’s Considered Normal?

Written by Jinfiniti Science on November 12, 2024. Posted in NAD, NAD+, NAD+ Precursors, Premature Aging. No Comments on NAD Levels by Age Group: What’s Considered Normal?

Your body is a vast metropolis, with billions of cells working around the clock to keep you alive and thriving. At the heart of this cellular city lies NAD+ ( short for nicotinamide adenine dinucleotide) – the power currency that keeps your cellular economy from entering a recession.

Just as a city needs electricity to function, every cell in your body needs NAD+ to convert food into energy, repair damaged DNA, and regulate your biological clock. This coenzyme helps your cells perform over 500 different biochemical reactions, making it one of the most important players in healthy aging and overall wellness.

Unfortunately, our bodies’ levels of NAD naturally decline as we age, dropping by up to 50% between our 20s and 80s. This decline is linked to many of the telltale signs of aging, from decreased energy levels to slower recovery after exercise. Understanding what’s “normal” for NAD+ levels at different ages can help us better grasp why we feel the way we do as time passes, and potentially, what we can do about it.

In this article, you’ll discover:

How NAD+ acts as your cells’ power currency, orchestrating over 500 vital biological processes that keep you healthy and energized
The natural timeline of NAD+ decline through aging, from peak levels in your 20s to significant decreases by age 50
Why men and women experience different patterns of NAD+ decline, and how hormones play a role
Science-backed strategies for maintaining optimal NAD+ levels, including why lifestyle changes alone aren’t enough to counter age-related decline

NAD+ and Aging

Middle-aged couple holding hands by the lake

Your body’s NAD+ levels follow a predictable pattern throughout life – and unfortunately, it’s a downward trend. Research shows that NAD+ levels peak during our early 20s and then begin a steady decline, with most people experiencing a 40-50% drop by age 50. But why does this happen? The answer lies in a perfect storm of biological events.

As we age, certain enzymes, particularly PARPs and CD38, become increasingly active and hungry for NAD+¹. PARPs ramp up their activity to repair age-related DNA damage, while CD38 levels rise as part of our body’s inflammatory response to aging. It’s like having more bills to pay but with the same paycheck – something has to give.

At the same time, our body’s ability to produce new NAD+ takes a hit. The molecular building blocks (or precursors) that we use to make NAD+ become less available, and the cellular machinery (biosynthetic enzymes) that assembles these pieces slows down². It’s similar to a factory facing both parts shortages and aging equipment – production inevitably drops.

This decline in NAD+ levels has real consequences for how we age. When cells can’t maintain healthy NAD+ levels, their energy production falters, DNA repair slows down, and cellular stress responses become sluggish. These changes contribute to many hallmarks of aging, from decreased muscle strength and slower wound healing to increased susceptibility to age-related diseases like cardiovascular problems and neurodegenerative conditions.

The Timeline of NAD+ Decline

NAD levels by age and across lifespan graphic chart

Infancy & Childhood (0-12 years)

NAD+ levels are naturally high and stable
Peak production supports rapid growth and development

Adolescence & Young Adulthood (13-30 years)

Levels reach their lifetime peak in early 20s
Optimal cellular energy and repair functions
Gradual decline begins around age 25

Middle Age (31-60 years)

Sharp decline begins
Most dramatic drop occurs between 40-49 years³
Average person loses 40-50% of young adult levels by age 50

Senior Years (60+ years)

Levels can drop to 1-10% of youthful amounts
By age 80, typical levels are less than half those at age 40
Continued gradual decline without intervention

What are Normal NAD Levels by Age Group?

Inside our cells, NAD concentrations can range from as low as 10 μM to as high as 1000 μM⁴. To put this in perspective, imagine filling a drop of water with different amounts of NAD – some cells maintain just a trace amount, while others keep a abundant supply, depending on their specific energy needs. When measured in tissue samples, researchers have found total NAD concentrations between 0.3 and 0.4 μmol/g.

Our research indicates that intracellular NAD+ concentrations of 40 µM or higher are associated with optimal cellular function, regardless of age. At 40 μM and above, many NAD-dependent enzymes, including some sirtuins and PARPs, can function effectively.

Measuring Your NAD Levels

Clinical evidence suggests that suboptimal NAD levels may contribute to various health challenges – from chronic fatigue and sleep disturbances to cognitive decline and metabolic disorders.

Modern methods like Jinfiniti’s Intracellular NAD Test now allow for precise measurement of cellular NAD concentrations through convenient at-home collection, enabling individuals to assess their personal NAD status and work to optimize their levels and address NAD deficiency symptoms through targeted interventions.

TEST YOUR NAD LEVELS TODAY

The Gender Gap in Age-Specific NAD+ Levels

Older couple on bench staring into the mountains

Studies have consistently shown that men tend to have higher baseline levels of whole blood NAD+ compared to women. In one large-scale study of over 1,500 participants, the average NAD+ level in men was 34.5 μmol/L, while women averaged 31.3 μmol/L⁵.

However, the way NAD+ levels change with age differs significantly between the sexes:

In men, NAD+ levels tend to decline gradually with age, with a more pronounced drop observed after age 60
Women, on the other hand, show a more complex pattern. Their NAD+ levels fluctuate across age groups without a clear downward trend

The distinct NAD+ profiles between men and women suggest that hormones play a role in regulating NAD+ metabolism. Researchers speculate that female sex hormones, particularly estrogen, may help maintain NAD+ levels throughout a woman’s life. This hypothesis is supported by observations in post-menopausal women, whose NAD+ patterns begin to resemble those of men.

The gender gap in NAD+ levels and their age-related changes may have far-reaching implications for how men and women age:

Higher NAD+ levels in men might provide them with a metabolic advantage in youth, but the steeper decline with age could contribute to accelerated aging in some aspects.
The more stable NAD+ levels in women could potentially offer some protection against certain age-related diseases, though more research is needed to confirm this.
The effectiveness of NAD+ boosting supplements or therapies may differ between men and women, necessitating gender-specific approaches to anti-aging treatments⁶.

Strategies for Increasing NAD+ Levels as You Age

While many people seek to naturally increase NAD levels through lifestyle modifications like exercise, intermittent fasting, and consuming NAD-rich foods, research shows these methods alone can’t fully counter age-related NAD+ decline. It’s like trying to fill a leaking bucket – as we age, our cells’ increasing demand for NAD+ outpaces what we can restore through lifestyle changes alone.

A more comprehensive approach involves strategic supplementation with NAD boosters that target the root cause of age-related NAD+ decline. The key lies in providing your body with the right precursors in the right combinations to optimize NAD+ production at the cellular level.

Recent clinical research has revealed that a synergistic approach yields better results than single-compound solutions. This breakthrough understanding led to the development of Vitality ↑® NAD+ Booster, a scientifically formulated combination of NMN, Creatine monohydrate, D-Ribose, and Nicotinamide. Each component plays a crucial role:

NMN serves as a direct NAD+ precursor
Creatine monohydrate supports energy metabolism
D-Ribose enhances cellular energy production
Nicotinamide helps regulate NAD+ consumption

What sets this formulation apart is its extensive validation – from clinical studies to real-world testing in hundreds of clinics. The data speaks for itself: approximately 85% of users achieve optimized NAD+ levels, as confirmed through clinical testing. This high success rate demonstrates that while aging’s effects on NAD+ levels are inevitable, they’re not irreversible.

Think of maintaining healthy NAD+ levels as a long-term investment in your cellular health. While lifestyle factors provide the foundation, targeted supplementation with clinically validated NAD boosters offers the most reliable way to maintain optimal NAD+ levels as you age. The key is choosing a solution backed by both scientific research and real-world results.

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Referenced Sources

Can NAD Supplements Help You Lose Weight?

Written by Jinfiniti Science on November 9, 2024. Posted in Glucose, NAD, NAD+, NAD+ Precursors. No Comments on Can NAD Supplements Help You Lose Weight?

Losing weight can feel like an uphill battle, especially when you’re dealing with stubborn fat, a sluggish metabolism, and constant fatigue. If you’ve tried everything from restrictive diets to intense exercise regimens, yet still struggle to shed those extra pounds, the solution may lie in a vital compound called NAD+.

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that plays a crucial role in cellular energy production, fueling a wide range of bodily functions, including metabolism. However, as we age, our natural NAD+ levels begin to decline, which can impact our ability to lose weight and maintain a healthy physique.

Fortunately, growing research suggests that supplementing with NAD+ precursors may hold the key to revitalizing your weight loss efforts. By boosting your NAD+ levels, you can potentially experience increased energy, enhanced fat-burning capabilities, and a faster, more efficient metabolism – all of which can contribute to successful and sustainable weight management.

So, can NAD supplements help you achieve your weight loss goals?

In this article, you’ll discover:

How NAD+ can help speed up your metabolism and burn fat more effectively.
The weight loss roadblocks NAD+ can help you break through for lasting results.
How NAD+ supplements can make managing your weight and metabolism easier and more sustainable.

NAD+ and Metabolic Function

NAD+ is a crucial molecule that powers our cells’ energy production. As a coenzyme, it supports several metabolic processes, including glycolysis, the citric acid cycle, and oxidative phosphorylation¹.

During glycolysis, NAD+ helps convert glucose (a type of sugar) into pyruvate, releasing energy in the process². This pyruvate then enters the next stages of energy production, where NAD+ helps extract even more energy from it.

For glycolysis to keep functioning, NADH (the reduced form of NAD+) must convert back into NAD+. This recycling ensures the process continues without a buildup of substances, supporting consistent energy production for all cellular activities, including metabolism.

In the citric acid cycle, NAD+ helps break down nutrients to produce high-energy electron carriers³. As nutrients are processed, NAD+ collects these high-energy electrons, which act like power boosts for our cells.

These electrons are then sent to the electron transport chain during oxidative phosphorylation, where their energy is used to produce ATP, the main energy currency of our body. This process is crucial for boosting metabolism and burning fat to manage weight effectively.

However, as we age, our bodies naturally see a decline in NAD+ levels. A 2022 study published in the journal Experimental Gerontology found that these levels can decrease by more than 50% from young adulthood to older ages⁴.

This decrease is alarming because low NAD levels can signal an energy deficiency⁵, making it harder for cells to metabolize nutrients effectively. Maintaining the right balance of NAD+ is crucial for optimal metabolic function and supporting healthy weight management.

With less NAD+, our energy production slows down, making it harder to burn calories efficiently. This slowdown can lead to weight gain or difficulty losing weight, contributing to those frustrating plateaus many experience in their fitness journeys.

NAD+ is also involved in regulating sirtuins⁶, enzymes that help manage fat metabolism and insulin sensitivity. As NAD+ levels fall, sirtuin activity can decrease, further hampering the body’s ability to regulate weight.

Moreover, NAD+ helps regulate autophagy, the process by which the body cleans out damaged cells. As we age, autophagy slows down⁷, and since NAD+ is needed for this to happen, lower levels can lead to a buildup of damaged cells. This accumulation can mess with your metabolism and contribute to weight gain.

NAD+ and Fat Tissues

NAD+ actively supports the functions of our fat tissues, specifically in white adipose tissue (WAT) and brown adipose tissue (BAT), which together enhance energy balance and optimize metabolic health.

WAT acts as an endocrine organ that secretes hormones like leptin, which regulate appetite and metabolism⁸. NAD+ influences the production and function of this hormone. For example, adequate NAD+ levels may improve leptin receptor sensitivity, which helps regulate appetite and reduce overeating.

Normal NAD+ levels are also necessary for the cells in WAT to respond well to insulin⁹, allowing glucose to be used for energy instead of being stored as fat. Low NAD+ levels can impair this process, contributing to insulin resistance and excess fat storage.

On the other hand, brown adipose tissue (BAT) contains a high concentration of mitochondria and burns energy to produce heat through thermogenesis¹⁰. This process is regulated by the protein UCP1 (uncoupling protein 1), which releases energy as heat instead of storing it.

NAD+ fuels BAT’s high metabolic rate and promotes the breakdown of stored fat for heat production. Activating BAT through NAD+ boosts thermogenesis, increasing overall energy expenditure¹¹, which can help with body weight management.

Another important role of NAD+ in fat tissues is its involvement in the “browning” of white fat. NAD+ helps trigger this transformation, where white fat cells convert into a more metabolically active form, similar to brown fat cells. As a result, these browned fat cells gain a higher mitochondrial density and can burn fat for energy.

A study published in Redox Biology shows that browning boosts fat’s metabolic activity¹², turning WAT from a passive storage site into an active fat-burning depot. This process can potentially reduce fat accumulation, especially in areas prone to stubborn fat storage.

The Science Behind NAD+ and Weight Loss

NAD+ is vital for cellular energy production. It helps convert glucose and fatty acids into usable energy within the mitochondria¹³, the powerhouses of cells. This energy drives everything from muscle function to body temperature regulation, making efficient energy conversion essential for managing weight.

The body’s metabolic flexibility, or the ability switch between burning fats and carbohydrates for fuel, is improved by NAD+, which supports energy conversion and activates metabolic enzymes.

While NAD+ helps support metabolic processes and energy expenditure, optimal levels are linked to healthier body composition¹⁴. Higher NAD+ levels are associated with better preservation of lean muscle mass, while low levels can contribute to fat accumulation.

Through its effects on cellular health and metabolic rate, NAD+ can help maintain a favorable balance between muscle and fat in the body, leading to a leaner physique over time.

Indeed, research shows that NAD+ may support weight management and improved body composition¹⁵. Healthy NAD+ levels also boost mitochondrial function and fat metabolism, which may contribute to weight management and metabolic health in the long run.

NAD+ also affects adiponectin, a hormone produced by fat cells that regulates glucose levels and breaks down fatty acids. Optimal NAD+ levels support adiponectin production¹⁶, which in turn improves insulin sensitivity and reduces inflammation.

This can help the body manage blood sugar better and reduce fat storage, both key factors in healthy weight management. So, while NAD+ itself might not directly burn fat, its role in reducing inflammation and supporting metabolic processes indirectly supports weight control and helps prevent metabolic dysfunctions that often accompany obesity.

Clinical Research on NAD for Weight Loss

Emerging research shows how NAD+ promotes weight loss and fat metabolism. While NAD+ has long been known as crucial for energy production, new studies reveal its potential to enhance the body’s ability to burn fat.

A study published in Frontiers in Nutrition involving 5,144 participants found that taking NAD+ precursors can lower Body Mass Index (BMI) and increase adiponectin levels.¹⁷ Specifically, people who took NAD+ supplements experienced a small yet significant reduction in BMI.

Another study published in the Journal of Nutritional Biochemistry looked at how nicotinamide (NAM) affects obesity in mice. The researchers found that NAM supplementation reduced fat mass and improved glucose tolerance¹⁸. It also increased mitochondrial proteins in fat tissue, suggesting that NAM boosts mitochondrial function, which is important for burning fat.

Moreover, NAM raised NAD+ levels by over 30% and enhanced glutathione production, supporting better metabolic function and easier weight management. Overall, NAM seems to reprogram how fat cells work to fight obesity-related issues.

Another study also found that NAD+ precursors can help with weight loss by improving insulin sensitivity and enhancing metabolic function. By boosting NAD levels, these precursors may help regulate energy expenditure and fat metabolism, making it easier for the body to burn fat.¹⁹

Overall, optimized NAD can help support better metabolic health and weight management and reduce obesity-related complications.

NAD+ Precursors and Their Weight Loss Effects

Of all the known NAD boosters, two of the most well-known are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

A 2021 study found that NR supplementation was associated with reduced weight gain and preservation of muscle mass. NR also aided in weight reduction and increased lean mass relative to body fat. In rats on calorie restriction, NR reduced inflammation in the hypothalamus²⁰, a brain region important for weight control.

These findings suggest that NR, especially when combined with calorie restriction, could aid in weight management by promoting fat loss without sacrificing muscle, as well as by reducing certain inflammatory markers.

NMN, another direct precursor of NAD+, also shows promising effects on body composition and metabolism. A study published in the IUBMB Life journal demonstrated that NMN helped reduce fat mass, preserved lean muscle, and improved glucose tolerance²¹.

The researchers also found that NMN lowers blood lipid levels and reduces liver fat, mitigating inflammation in fat tissue and addressing fatty liver issues often seen with obesity. NMN appears to support a shift toward a healthier body profile.

On top of that, NMN’s ability to reduce fat tissue inflammation, improve insulin sensitivity, and boost insulin secretion could make it a helpful tool for balancing blood sugar and supporting a leaner body—both important for managing weight and metabolic health.

While NR and NMN are among the most studied NAD+ precursors, two other forms of vitamin B3, niacin and nicotinamide, also contribute to NAD+ production and deliver their own unique benefits to help with weight management and overall metabolic function.

Niacin assists in the body’s fat and sugar processing, supporting cellular health, which is essential for weight control. At higher doses, niacin can also improve blood triglyceride levels, helping prevent fat accumulation and promoting a balanced body composition.

In fact, a study published in Cell Metabolism found that niacin effectively boosts NAD+ levels in adults. At doses up to 1,000 mg daily, blood NAD+ levels increased up to eightfold, and participants experienced a significant liver fat reduction of up to 50%.²²

Nicotinamide, on the other hand, shows promise in metabolic function improvement through reducing fat mass and increasing lean muscle. In 2021, a study found that Nicotinamide improved weight management in mice²³. When given to them, Nicotinamide increased how much energy they burned and changed their body fat composition. The mice ended up with more brown and beige fat, which is good for burning calories.

In addition to well-known NAD+ precursors, D-ribose is another supplement worth trying. This naturally occurring sugar doesn’t directly increase NAD+ levels like the others, but it helps the body produce ATP, which in turn supports NAD+ production. This makes D-ribose another useful tool for boosting energy and metabolism.

At the end of the day, taking a holistic approach when using NAD precursors to improve metabolic function for weight loss is key to maximizing results. Jinfiniti’s Vitality ↑® NAD+ Booster exemplifies this by combining four synergistic ingredients: NMN, Creatine monohydrate, D-ribose, and nicotinamide.

This unique formulation supports cellular metabolism and energy to help your body lose weight efficiently. This clinically validated formulation ensures you’re not just supplementing but revitalizing your entire well-being by increasing NAD at the cellular level.

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Does NAD IV Therapy Work for Weight Loss?

NAD IV therapy has become a buzzword for those seeking weight loss, but it’s important to manage expectations. While NAD therapy boosts extracellular NAD levels, which can help with energy and metabolism, it shouldn’t be the sole strategy for shedding pounds.

When considering NAD supplements versus IV therapy, it’s important to understand their differences. NAD precursor supplements are easy to take regularly and support long-term cellular health, offering a gradual boost to NAD+ levels and metabolism over time. This makes them a good choice for steady, ongoing weight management.

In contrast, NAD IV treatment provides a higher, more immediate dose of NAD+, delivering quicker effects. While it can temporarily increase energy levels and metabolism, the impact on long-term fat loss or significant weight reduction may be limited without accompanying lifestyle changes.

Moreover, NAD IV therapy can be costly, and some people experience side effects like headaches, nausea, or dizziness. These effects are generally temporary but it’s important to be aware of them before undergoing treatment.

So, if you’re considering NAD injections for weight loss, it’s important to remember that it should be part of a broader strategy that includes a balanced diet and regular exercise. Ultimately, the choice depends on your personal health goals and budget.

Potential Side Effects of NAD Supplementation

Current evidence points to NAD+ supplements being generally safe and well-tolerated, with some important caveats: long-term effects of high doses aren’t fully understood yet, and the supplement market’s limited regulation poses inherent risks.

Variable product quality and potential impurities remain ongoing concerns, making it important to opt for manufacturers that demonstrate their commitment to quality through independent testing.

How to Increase NAD Levels for Weight Loss

Increasing your NAD levels is a powerful way to support metabolism and make weight management easier, and there are a few simple steps to get started.

First up: diet. Choosing niacin-rich foods like vegetables, whole grains, and lean proteins can give your body the building blocks it needs to produce more NAD+. Even adding fermented foods, like kimchi and sauerkraut, can help out with a small NAD+ boost while benefiting gut health.

Next, staying active is key. Exercise—especially high-intensity and endurance workouts—naturally supports NAD production in your cells. Whether it’s a brisk walk, a run, or a strength session, regular movement keeps your energy high and your metabolism on point.

Making small lifestyle tweaks also goes a long way. Practicing intermittent fasting or occasional calorie restriction can jumpstart autophagy, clearing out old cells and ramping up NAD production. And managing stress through meditation or yoga can help prevent oxidative stress, allowing your NAD levels to stay stable.

For added support, consider NAD-boosting supplements that contain clinically proven precursors such as Vitality ↑® NAD+ Booster. These can help optimize your NAD+ levels, supporting your journey toward achieving your ideal weight and physique.

If you’re experiencing symptoms like fatigue, weight gain, or difficulty shedding pounds, it could be a sign of NAD deficiency. Taking an Intracellular NAD Test can help you assess your baseline levels, giving you a clearer picture before starting any interventions.

With regular testing, you can fine-tune your supplementation and track whether your current dosage or supplement is effectively supporting your weight loss goals.

TEST YOUR NAD LEVELS TODAY

Referenced Sources:

Can NAD Boosters Turn Back the Clock on Aging?

Written by Jinfiniti Science on November 5, 2024. Posted in NAD, NAD+, NAD+ Precursors, Premature Aging. No Comments on Can NAD Boosters Turn Back the Clock on Aging?

The quest for staying young has fascinated humans for centuries. While we haven’t found the fountain of youth, scientists have discovered something intriguing: NAD, short for nicotinamide adenine dinucleotide, a molecule that plays an all-important role in how we age.

As our NAD levels naturally decline over time, researchers are exploring whether boosting these levels could help slow down the aging process. But can these NAD boosters—ranging from supplements like nicotinamide riboside and NMN to therapies like NAD IV infusions—actually turn back the clock, or are they just another anti-aging promise?

In this article, we discuss…

How NAD+ Boosters work to support your body’s natural NAD production and reverse the signs of aging
Why maintaining healthy NAD levels matters for your long-term health and vitality
What science tells us about the safety and results of NAD+ Boosters

What Are NAD Boosters?

NAD boosters are compounds and interventions designed to increase NAD+ levels in cells and tissues, targeting the natural decline of this critical coenzyme that occurs with aging. NAD+ is a powerful molecule found in every cell, essential for converting food into energy, repairing DNA, and supporting overall cellular health. As we age, our natural NAD+ production decreases, which can lead to reduced metabolic function, decreased energy, and potential cognitive decline.

NAD+ boosting supplements typically contain precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) among others that help replenish cellular NAD+ levels. These supplements work by providing the body with molecules that can be easily converted into NAD+, potentially supporting healthy neurologic function, improving mood, and increasing metabolism. Research suggests that NAD+ boosters may offer benefits such as enhanced mental clarity, reduced inflammation, and improved cellular energy production¹.

While NAD+ boosters show promising potential, individuals can also naturally increase their NAD+ levels through lifestyle approaches like diet, regular exercise, intermittent fasting, limiting alcohol consumption, and eating protein-rich foods. However, for those seeking a more direct approach, NAD+ precursors provide a targeted method to support cellular health and potentially mitigate age-related decline.

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Do NAD+ Boosters Really Work?

You may have heard a lot of buzz about NAD+ boosters and their potential to support healthy aging and improve cellular function. But do they really work? The research so far is promising.

Numerous studies have shown that various NAD precursor compounds (often colloquially referred to as NAD boosters) effectively increase NAD+ levels in human subjects.

For example, a well-designed, randomized, double-blind, placebo-controlled trial demonstrated that regular supplementation with nicotinamide riboside (NR) significantly increased NAD+ levels in healthy middle-aged and older adults². The benefits were impressive, too, including reduced blood pressure and improved arterial flexibility.

Another study that combined NR with pterostilbene (NRPT) reported a 40% increase in NAD+ levels after just four weeks, with sustained improvements over eight weeks³. These findings suggest that certain NAD boosters can be a safe and effective way to enhance NAD+ metabolism and potentially deliver health benefits that combat aging.

However, the reality is that not everyone will experience the same results. Individual responses to NAD boosters can vary widely. Factors such as your baseline NAD+ levels, age, gender, genetics, and overall health play significant roles in how well these interventions work for you.

For example, some studies have reported modest increases in NAD+ levels of 40-59% with lower doses of NR or NMN, while others have observed more substantial increases—up to 5.7-fold—with higher doses⁴. Ultimately, it comes down to how your body metabolizes these compounds.

What works for your friend or family member might not work as well for you, and finding the right dosage or formulation can take some trial and error. Moreover, various therapeutic approaches, such as NAD supplementation versus IV therapy, will tend to yield distinct outcomes.

Since everyone’s health needs differ, it’s always recommended to consult with your healthcare provider regarding the appropriateness of any new intervention or supplementation regime for your specific situation.

Potential Benefits of NAD Boosters

When your body maintains optimal levels, the benefits of NAD can touch virtually every aspect of your health and well-being, from energy production to DNA repair. Here’s how optimizing your NAD+ levels may help support your body:

Supporting heart health and circulation: NAD+ promotes cardiovascular function and healthy blood flow⁵.
Enhancing metabolic function: NAD+ aids in efficient energy metabolism⁶ and blood sugar regulation.
Boosting brain health and cognitive function: NAD+ improves mental clarity, memory, and overall brain performance⁷.
Increasing muscle strength and athletic endurance: NAD+ enhances physical performance⁸ and muscle recovery.
Reducing chronic inflammation: NAD+ helps lower inflammation⁹, supporting a healthier immune response.
Improving sleep and rest quality: NAD+ encourages better sleep patterns¹⁰ and more restorative rest.
Alleviating symptoms of anxiety and depression: NAD+ may help regulate mood and reduce feelings of stress and anxiety¹¹.
Supporting cellular energy production: NAD increases ATP production¹², combating fatigue and boosting daily energy.
Promoting skin repair and slowing aging: Supports skin regeneration and reduces visible signs of aging¹³.

Many people notice these improvements within weeks of starting NAD boosters, though individual results may vary. The key is consistency – giving your body the regular support it needs to maintain optimal NAD+ levels and function at its best.

Are NAD Boosters Safe?

NAD precursors are known for their strong safety profile. In fact, most people tolerate them well when taken as recommended¹⁴. However, like any supplement or medication, NAD boosters can come with potential side effects, particularly if misused or taken in excessive amounts.

Generally, side effects from NAD boosters are rare and mild. If they do occur, they may include temporary stomach discomfort, mild headaches when first starting, fluctuations in energy levels, or occasional changes in sleep patterns. These effects typically improve as the body adjusts to the supplement.

If you’re considering NAD IV therapy, it’s essential to have the procedure performed by a skilled healthcare professional to reduce the risk of complications, such as infection, vein irritation, and other possible side effects of NAD IV therapy.

Moreover, if you are pregnant, nursing, have underlying health conditions, take prescription medications, or have autoimmune disorders, it’s important to consult your doctor before using supplements like NAD boosters, as these supplements could cause side effects or interact with your medications.

To get the most from NAD boosters while minimizing risks, choose high-quality products from reputable brands, begin with the recommended dosage, and pay attention to how your body responds. Always communicate with your healthcare provider and schedule regular check-ups to monitor your progress.

Ultimately, while NAD boosters are safe and can support healthy aging and cellular function for most individuals, they are most effective when combined with a balanced lifestyle, including proper nutrition, regular exercise, and quality sleep.

Who Should Consider Taking NAD Boosters?

While NAD+ levels are generally higher in younger populations, everyone can potentially benefit from supporting their NAD+ balance, depending on lifestyle, health needs, and age-related decline.

For younger individuals, NAD+ levels are typically sufficient to support metabolic and cellular functions, making supplementation less necessary. However, children and young adults experiencing high stress, engaging in intense physical activities, or recovering from health issues may still benefit from maintaining balanced NAD levels.

For adults, especially those in their 40s and older, the natural decline in NAD+ becomes more pronounced, often leading to reduced energy, a slower metabolism, and cognitive changes. At this stage, NAD boosters can help counteract age-related declines, enhance energy levels, and support overall cellular health.

Individuals experiencing symptoms of NAD deficiency, such as persistent fatigue, cognitive difficulties, or metabolic issues, should consider getting their NAD levels tested to determine if intervention is needed. The Intracellular NAD Test provides a precise measurement of cellular NAD levels, helping identify deficiencies that may benefit from targeted NAD-boosting strategies. For those with confirmed low NAD levels, implementing appropriate interventions can help restore optimal cellular function and improve overall wellbeing.

TEST YOUR NAD LEVELS

Choosing the Right Supplement to Boost NAD

Choosing the best NAD+ supplement is important for maximizing its health benefits, and your decision should be guided by factors such as bioavailability, cost, form, and overall product quality.

For the best results, look for supplements that contain highly absorbable forms of pure NAD precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), both of which can effectively increase NAD levels in the body.

When choosing a NAD+ booster, quality and purity should never be compromised. Always select products from reputable brands that perform rigorous testing for safety and purity. Third-party lab testing ensures the supplement is free from contaminants and delivers the promised potency.

Jinfiniti’s Vitality ↑® NAD+ Booster stands out with its clinically proven, patent-pending formulation that combines four powerful ingredients to optimize NAD levels and revitalize cellular function. This unique blend includes an NAD precursor, creatine monohydrate, D-ribose, and nicotinamide, working synergistically to enhance NAD production through multiple pathways. The formulation is particularly effective as it includes both a one-step NAD precursor and supports the salvage pathway that recycles nicotinamide, while creatine monohydrate serves as an ATP energy reservoir and potential neurotransmitter. All ingredients in Vitality NAD are third-party tested for the highest purity, with Certificates of Analysis available upon request.

DISCOVER VITALITY ↑®

Referenced Sources:

10 Major Health Benefits of NAD

Written by Jinfiniti Science on October 31, 2024. Posted in NAD, NAD+. No Comments on 10 Major Health Benefits of NAD

Short for Nicotinamide Adenine Dinucleotide, NAD is an essential coenzyme naturally present in every cell of the body that has become popular for its profound effects on human health.

As we age, our NAD levels decline, which can lead to a host of age-related ailments ranging from cognitive decline to chronic fatigue. However, with the advent of NAD supplements and therapy, it’s now possible to counteract these effects, potentially reversing the signs of aging.

Recent studies show that maintaining optimal NAD+ levels in check can have a real impact on health, supporting everything from cellular repair to brain health. In fact, it could be a key player in helping you feel and function at your best.

So, how can NAD+ truly make a difference in your health?

In this article, you’ll discover:

10 surprising benefits of NAD that go beyond just boosting energy

The different benefits of NAD supplements and NAD IV therapy, and how each could support your wellness goals

Important safety guidelines, potential side effects, and who might benefit the most from NAD therapy

What is NAD?

Every cell in your body relies on a molecule called NAD, short for nicotinamide adenine dinucleotide, to keep the lights on. This coenzyme is like a molecular power plant, essential for turning food into energy and for keeping countless biochemical reactions running smoothly.

NAD exists in two forms, NAD+ and NADH¹, which function together in redox reactions to facilitate energy production, DNA repair, and cellular signaling

NAD+ is the oxidized form of the molecule, capable of accepting electrons during metabolic processes², which is crucial for energy production and various biochemical reactions. In contrast, NADH is the reduced form that results when NAD+ gains electrons.³ This conversion allows NADH to act as an important electron carrier, shuttling electrons to support cellular functions.

Unfortunately, NAD+ levels don’t remain stable throughout our lives.⁴ In fact, they naturally decline over time. By the time we hit middle age, our NAD+ levels could be nearly half of what they were in our youth.

As we age, our bodies produce less NAD+ due to a combination of factors, including accumulated DNA damage, changes in metabolic processes, and increased activity of NAD+-consuming enzymes.⁵ This drop can lead to slower cellular functions, less efficient DNA repair, and even faster aging at the cellular level.

Researchers have found that this decline in NAD+ can lead to various age-related issues,⁶ like fatigue, and cognitive decline, and even increase vulnerability to diseases such as cardiovascular disease and obesity.

No wonder why NAD supplements have become popular in optimizing NAD levels and supporting healthy aging.

What are NAD Supplements?

NAD+ supplements are products developed to help increase levels of NAD+ in the body, especially as we age, when our levels significantly decline. They come in various forms — such as powders, capsules, and tablets which are convenient for daily use.

There are also sublingual strips that dissolve under your tongue for quicker absorption. If you have trouble swallowing pills, NAD+ supplements are also available in liquid forms.

The best NAD supplements contain pure NAD+ precursors, which are building blocks your body uses to make NAD+. The most common precursors are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

NR is a form of vitamin B3 that the body can easily convert into NAD+. Many people take NR to boost their energy levels and support healthy aging. It may even help with exercise performance⁷, making it a favorite among fitness enthusiasts.

Like NR, NMN also helps increase NAD+ levels in the body. It’s particularly effective at supporting cellular health and promoting longevity. Research has shown that NMN can benefit heart health⁸ by protecting heart cells from age-related damage.

It can also support healthy metabolic function, energy production, and overall cellular health, which is crucial for maintaining vitality and combating age-related declines.

Therefore, with the right NAD supplement, you can potentially counteract the many symptoms of NAD deficiency that most people experience as they get older.

NAD Supplement Benefits

Is your NAD level optimized? It should be! Here are 10 of the major therapeutic benefits of optimal NAD levels.

NAD supports cellular health, potentially extending lifespan

NAD+ is essential for cellular health, supplying the energy cells need to function effectively and supporting DNA repair to keep our genetic material intact and healthy. Additionally, it activates sirtuins, known as “longevity proteins,”⁹ that help manage inflammation and aging. By energizing cells and promoting effective repair, optimized NAD levels may extend our lifespan and help keep our bodies healthy as we grow older.

NAD promotes heart health and circulation

NAD+ supplementation shows promise in improving cardiovascular health by improving heart function and vascular integrity. Studies have demonstrated that NAD+ precursors can reduce high blood pressure, ameliorate vascular dysfunction, and decrease arterial stiffness in hypertensive patients and animal models.¹⁰ NAD+ replenishment has been shown to protect against age-related arterial stiffening, improve endothelial function, and potentially reduce the risk of cardiovascular events.¹¹

NAD plays a role in maintaining metabolic health

NAD+ also supports fat-burning and glucose metabolism,¹² which play an essential role in maintaining a healthy weight. NAD+ boosts energy production, which helps improve overall metabolism, making it easier for the body to manage its energy levels. This leads to better energy balance and reduces the risk of metabolic disorders like obesity and diabetes.

NAD can help improve cognitive function

NAD+ also boosts brain health by generating the energy needed for mental clarity, focus, and sharp thinking. It supports DNA repair and healthy inflammatory responses in the brain, which is protective against age-related cognitive decline and neurodegenerative disorders.¹³ With optimal NAD+ levels, you may notice sharper memory, better focus, and clearer thinking.

NAD boosts muscle strength and athletic endurance

If you’re an athlete, a bodybuilder, or simply just an active person, NAD+ can boost your athletic performance. Thanks to its ability to fuel your body with the energy needed for muscle contractions during exercise.¹⁴ It also supports muscle recovery by promoting repair and reducing fatigue after workouts. This means you can train harder, recover faster, and improve your overall performance in sports and any physical activities.

NAD reduces chronic inflammation in the body

NAD+ plays a consequential role in managing chronic inflammation.¹⁵ It supports your immune system and regulates inflammatory responses, significantly reducing your risk of health issues like heart disease and arthritis. Maintaining optimal NAD+ levels allows your body to promote healthy inflammation processes, ultimately helping you feel better and healthier over time.

NAD may improve sleep patterns and overall rest quality

NAD+ also supports your body’s internal clock,¹⁶ a key factor in getting quality sleep. When NAD+ levels are high, they drive up the production of melatonin, the drowsy-making hormone that tells your brain “it’s time to drift off.” With robust NAD+ levels, you’re more likely to sink into the kind of deep, restorative sleep that leaves you bouncing out of bed in the morning, sharp-minded and energized, rather than fighting with your snooze button.

NAD could alleviate symptoms of anxiety and depression

Keeping your NAD+ levels in check can help your brain’s neurotransmitters—like serotonin and dopamine—work more effectively. These chemicals play a big role in how we feel, so with a better balance of them, you might notice a drop in anxiety and depression,¹⁷ along with an overall mood lift.

NAD increases cellular energy production, fighting fatigue

You can also combat fatigue effectively with the help of NAD supplements. NAD+ is a key player in mitochondrial function, converting nutrients from food into usable energy for your cells. With an optimized NAD+ level, your body can generate energy more efficiently, reducing tiredness throughout the day.¹⁸

NAD supports skin repair and slows visible signs of aging

Last but certainly not least, NAD+ contributes to skin repair and helps slow visible signs of aging. It promotes cell regeneration, keeping your skin looking healthy and youthful. When your NAD levels are optimized, your skin gains remarkable resilience against environmental assaults – from harsh UV rays to urban pollutants.¹⁹ Over time, this leads to a more even skin tone, fewer wrinkles, and a radiant complexion that truly glows.

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Potential Benefits of NAD Therapy

Outside of supplementation, NAD therapy is quickly becoming a popular choice for those looking to increase NAD levels. This treatment involves infusing the body with NAD+ directly without the delays of digestion.

During the session, a healthcare provider places a small IV line in your arm, and the NAD+ solution is infused over a set time. The goal is to achieve rapid absorption and effects without going through the digestive system.

Regular NAD therapy sessions can offer several potential benefits:

Feeling a surge of natural energy that lasts throughout your day
Experiencing sharper focus and clearer thinking, like a mental fog has lifted
Watching as your body repairs itself more efficiently
Finding yourself handling stress better while enjoying a more balanced mood
Getting extra support in managing ongoing health challenges
Noticing a more youthful appearance and improved vitality over time

Safety and Tolerability of NAD Therapy

NAD therapy is generally considered safe for most people, but like any treatment, it comes with potential risks and safety concerns. Some people may experience mild side effects of NAD therapy during or after sessions. Common reactions include:

Nausea
Headaches
Fatigue
Flushing or warmth
Dizziness
Mild anxiety
Changes in heart rate

More serious side effects are rare but can also occur. Some people may experience allergic reactions, which could manifest as rashes, itching, or swelling. Therefore, it’s important to monitor how your body responds during and after the treatment, especially if you have a history of allergies.

Additionally, complications related to IV administration can arise,²⁰ such as infection at the injection site, vein irritation, or blood clots. Although these are uncommon, your NAD IV must be done by a trained professional in a sterile environment to minimize risks.

Finding the right dose of NAD+ for therapy is also important for achieving desired results without unnecessary side effects. The optimal dosing may vary based on individual needs, age, and health status. Typically, doses can range from 250 mg to 1,000 mg per session, administered intravenously for one to three hours, or even longer.

Your healthcare provider can help you determine the best protocol for you based on your specific circumstances and treatment goals.

Who is NAD Therapy For?

NAD therapy can be of great benefit to many people, including:

Individuals experiencing persistent fatigue
Those with cognitive performance concerns
Athletes and fitness enthusiasts
Individuals in addiction recovery
Those focused on healthy aging

Like any treatment, NAD therapy isn’t for everyone. Although NAD therapy is generally well-tolerated, it may not be suitable for:

People with severe kidney or liver conditions
People with known allergies to NAD+ infusion components
Pregnant or nursing individuals

Is NAD Supplementation Right for You?

While NAD levels naturally decline with age, supplementation provides a science-backed approach to maintaining optimal cellular health. The extensive benefits we’ve explored – from enhanced energy production and cognitive function to improved metabolic health and longevity support – make NAD supplementation an attractive option for many adults seeking to optimize their wellness.

Research consistently shows that NAD supplementation is generally well-tolerated, with minimal side effects reported in clinical studies. However, before starting any new supplement regimen, it’s valuable to understand your baseline levels. Testing your intracellular NAD levels can provide clear insights into whether supplementation would be beneficial for your specific situation.

Jinfiniti’s Intracellular NAD® Test offers precise, laboratory-grade testing that measures NAD where it matters most – inside your cells. This testing can help establish your baseline levels and allow you to track your progress while supplementing, ensuring you’re achieving optimal results from your NAD support strategy.

TEST YOUR NAD LEVELS TODAY

Referenced Sources:

NAD Deficiency Symptoms: 6 Common Signs of Low NAD Levels

Written by Jinfiniti Science on October 28, 2024. Posted in Depression and Anxiety, Energy and Fatigue, Memory Loss and Brain Fog, NAD, NAD+, Skin Health, Sleep. No Comments on NAD Deficiency Symptoms: 6 Common Signs of Low NAD Levels

Feeling sluggish, mentally foggy, or struggling to keep up with your routine lately?

While it’s quite normal to feel this way from time to time, you shouldn’t take these frustrating signs for granted.

What seems like just another bad day could be a telltale sign that your NAD+ levels are running low.

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that plays a critical role in energy production, DNA repair, and overall health.

Unfortunately, NAD+ levels naturally decline with age and can be further affected by lifestyle factors, leading to a range of symptoms that are often overlooked.

So, what are these warning signs, and how can you optimize your NAD+ levels to stay healthy and active as you age?

In this article, we discuss:

Why your NAD levels are dropping faster than you think—and it’s not just because you’re getting older.

7 subtle signs of NAD deficiency that many people dismiss as “just part of aging,” but shouldn’t.

The red flags of severe NAD deficiency you can’t afford to ignore.

How to accurately detect low NAD levels in your body and the easiest, most effective ways to boost them naturally.

Understanding NAD+ and Why It Declines

Nicotinamide adenine dinucleotide, or NAD+, is an essential coenzyme found in every cell of our body. It plays a key role in several critical processes, including energy metabolism, DNA repair, and cellular signaling.¹

Essentially, NAD+ acts like a shuttle for electrons during metabolic reactions, helping to transform the food we consume into usable energy and supporting the production of ATP, which is the main energy currency for our cells.

Beyond just energy production, NAD+ also maintains the integrity of our DNA and regulates various cellular functions that keep us healthy.

Unfortunately, by the time we reach our 30s, our NAD+ levels start to decline. In fact, NAD+ can decrease by up to 50% as we age,² with noticeable reductions in the skin and other tissues.

This decline can be accelerated by factors like oxidative stress,³ unhealthy diets, and lifestyle choices, leading to symptoms that are often mistaken for the typical signs of aging.

But in reality, these may be early signs of low NAD+ levels, indicating that it’s time to take action and make necessary lifestyle changes to support your health and longevity.

Common Symptoms of NAD+ Deficiency

Below are six common health symptoms that indicate you may be deficient in NAD.

Fatigue and Low Energy

NAD is essential for energy metabolism. Think of it as the engine that powers your body, helping convert the food you eat into usable energy. However, when your NAD+ levels drop, it can disrupt your metabolism and may result in fatigue and low energy.

Your body might also struggle to produce ATP (adenosine triphosphate), which is your main source of energy. The result? You might feel sluggish and worn out. NAD+ also supports the proper functioning of enzymes that protect against oxidative damage.

When these protective enzymes can’t do their job because of low NAD levels, it creates an imbalance between harmful reactive oxygen species and protective antioxidants⁴ that can further drain your energy and leave you feeling even more fatigued.

Moreover, NAD+ is important in metabolizing carbohydrates, fats, and proteins. When your NAD+ levels are low, these metabolic pathways can become inefficient, leading to even more tiredness. For instance, if your body can’t break down fatty acids properly, it can accumulate unused substrates that sap your energy.

Not to mention, during physical activity, your muscles depend heavily on NAD+ for energy.⁵ If you’re low on NAD+, you might experience muscle weakness and decreased endurance, making even simple tasks feel much more challenging.

Cognitive Symptoms

NAD is also important for maintaining healthy cognitive function. When your levels drop, you might start to notice some cognitive symptoms, such as mental fog, memory lapses, and a general decline in sharpness.

This is because NAD+ is crucial for energy metabolism and mitochondrial function, both of which are essential for your brain to perform at its best. When NAD+ levels are low, the brain struggles to produce adenosine triphosphate (ATP)⁶—the energy that powers our cells—leading to sluggish thinking and that frustrating feeling of mental cloudiness or fatigue.

Research shows that a deficiency in NAD+ can worsen neuroinflammation and oxidative stress, both of which are harmful to cognitive health, potentially leading to increased neuronal damage and cognitive issues,⁷ such as forgetfulness and decreased mental agility.

Skin and Appearance Changes

Is your skin looking dry and dull despite your diligent skincare routine and healthy lifestyle? One hidden culprit could be low NAD+ levels.

Research shows that low NAD+ levels can hinder your skin’s ability to repair itself, particularly from damage caused by sun exposure. This impairment can result in more visible signs of aging, such as wrinkles and loss of elasticity.

Additionally, because NAD+ plays a key role in supporting mitochondrial function—the process that provides the energy your skin cells need to regenerate and stay vibrant⁸—low NAD+ levels can impede cell renewal. This leaves your skin looking tired, dull, and less radiant.

Poor Sleep Quality

Having trouble getting a restful night’s sleep? It could be more than just stress or a racing mind—it might actually be a deficiency in NAD+ levels.

As a coenzyme, NAD+ supports energy production and maintains healthy cells, including those involved in regulating your sleep cycle. When NAD+ levels decline, especially as we age, this drop can disrupt your sleep patterns.

Since NAD+ helps regulate key “clock” genes that control your sleep-wake cycle, it can throw off your body’s internal clock, or circadian rhythm,⁹ making it harder to fall asleep or stay asleep through the night.

Research also reported that NAD+ is essential for the synthesis of serotonin from tryptophan, a precursor amino acid.¹⁰ If NAD+ levels drop, this metabolic pathway can become inefficient, potentially leading to reduced serotonin and subsequently lower melatonin levels.

Therefore, you may experience sleep disturbances and increased fatigue due to inadequate melatonin production.

Mental Health and Mood Swings

Low NAD+ levels can significantly affect your mood and mental health, often manifesting as mood swings, irritability, anxiety, or even depression.

This occurs because NAD+ deficiency disrupts the balance of crucial neurotransmitters like serotonin, dopamine, and norepinephrine,¹¹ which are essential for regulating mood and emotional responses. As a result, you may experience persistent feelings of anxiety or sadness.

NAD+ is also important in activating sirtuins—proteins that help cells manage stress.¹² When NAD+ levels are low, sirtuins become less effective, which can contribute to mental health challenges like anxiety and irritability.

This makes it harder for your brain to cope with stress, intensifying emotional imbalances.

Metabolic Health Issues

NAD+ deficiency can lead to various metabolic problems,¹³ including weight gain, insulin resistance, and a higher risk of metabolic disorders.

NAD+ underpins key metabolic processes like glycolysis, the TCA cycle, and oxidative phosphorylation. When NAD+ levels drop, these processes become less efficient, disrupting energy metabolism and contributing to issues such as weight gain and insulin resistance.

Low NAD+ also affects enzymes involved in energy production, leading to reduced ATP synthesis and increased fat storage, particularly in the liver and fat tissue. This buildup of fat triggers inflammation, further worsening insulin resistance.

Moreover, NAD+ activates sirtuins, proteins that help regulate glucose and fat metabolism. When NAD+ levels are low, sirtuin activity declines, making it harder for the body to control blood sugar and insulin sensitivity,¹⁴ which raises the risk of type 2 diabetes.

People with low NAD+ levels are also more prone to developing metabolic conditions like diabetes and non-alcoholic fatty liver disease (NAFLD).

Severe NAD+ Deficiency Symptoms

People with NAD+ deficiency may also experience severe symptoms similar to pellagra, a condition caused by niacin deficiency.¹⁵

These symptoms indicate a critical lack of NAD+.

Dermatitis typically manifests as a scaly rash that worsens with sun exposure, indicating the body’s diminished capacity for healing due to low NAD+ levels. Diarrhea stems from impaired gut function and disrupted metabolism, which can lead to dehydration and poor nutrient absorption. Cognitive issues like memory loss and confusion arise because NAD+ is integral for brain cell energy production and neuronal health.

If left untreated, NAD+ deficiency can result in severe metabolic dysfunction,¹⁶ increasing the risk of serious conditions such as cardiovascular disease, diabetes, neurodegenerative disorders, and even death.

Cardiovascular Impact of NAD+ Deficiency

Low NAD+ levels can greatly increase the risk of cardiovascular diseases,¹⁷ hypertension, and reduced heart function. When NAD+ levels decline, vital processes like energy metabolism, DNA repair, and oxidative stress management become compromised, leading to a range of cardiovascular issues, especially hypertension.

Research published in the Signal Transduction and Targeted Therapy shows that hypertensive patients have a 44% lower NAD+ level in their peripheral blood mononuclear cells¹⁸ compared to those with normal blood pressure. This reduction is closely linked to impaired vascular function and elevated arterial pressure.

Additionally, NAD+ deficiency can cause mitochondrial dysfunction, which is crucial for maintaining cardiac energy metabolism.¹⁹ This leads to reduced ATP production and increased oxidative stress, both of which contribute to heart failure and other cardiovascular problems.

The enzyme CD38, which depletes NAD+, is often overactive in hypertensive individuals, further draining NAD+ levels and negatively affecting vascular health and heart function.

Beyond hypertension and weakened heart function, chronically low NAD+ levels can increase the risk of severe cardiovascular diseases like atherosclerosis and coronary artery disease,²⁰ which, if not addressed, can result in life-threatening events such as heart attacks and strokes.

NAD+ Deficiency in Specific Populations

While it’s common knowledge that NAD+ levels decline after the age of 30, certain groups are at a higher risk of experiencing a deficiency.

Obese individuals, for example, tend to have significantly lower NAD+ levels²¹ than those with a healthy weight. This is because excess fat triggers chronic inflammation and metabolic imbalances, which further deplete NAD+ levels.

Obesity is also associated with impaired NAD+ metabolism, increasing insulin resistance,²² and elevating the risk of type 2 diabetes and related conditions.

Genetic disorders also contribute to NAD+ deficiency risk. Individuals with conditions like congenital NAD deficiency disorder (CNDD)²³ experience inadequate NAD+ production, leading to developmental abnormalities and other health complications.

Genetic mutations that interfere with enzymes responsible for NAD+ synthesis reduce the availability of this vital coenzyme, contributing to congenital defects and increased health risks.

Given all these factors, the important question is: Are you NAD+ deficient? The only way to find out is to test.

How to Test if Your NAD Levels Are Low

Now that you understand the signs of NAD deficiency, how do you find out if your NAD levels are truly suboptimal?

At Jinfiniti, we prioritize precision over guesswork. That’s why we recommend the most reliable approach: testing your NAD+ levels directly.

Our Intracellular NAD Test gives you a clear picture of what’s happening inside your cells. We measure your actual NAD+ levels to help you see where you stand – whether they’re running low, sitting at a healthy baseline, or higher than average. With these insights, you can make smarter decisions about your NAD+ supplements and know if they’re really working for you.

TEST YOUR NAD LEVELS TODAY

How to Treat Low NAD Levels

If you suspect your NAD+ levels are low or have confirmed a deficiency through testing, there are several evidence-based approaches to increase your NAD+ levels naturally and through supplementation. The key is finding the right combination of lifestyle modifications and targeted support for your individual needs.

Research shows that regular exercise, particularly high-intensity training, naturally boosts NAD+ production. Combining this with a diet rich in B3 vitamins and stress management techniques can help optimize your body’s NAD+ levels while preventing excessive depletion of existing stores.

For those seeking intensive support, medical NAD+ therapies like IV infusions are available at specialized clinics. While these treatments can rapidly elevate extracellular NAD+ levels, they are costly and may cause side effects like flushing and headaches, requiring close medical supervision.

A more accessible and scientifically-validated approach is supplementation with NAD+ precursors.

Our High Purity NAD+ Precursor powder offers a premium-grade, pure form of NAD+ as a building block that your body can efficiently convert into active NAD+.

For those seeking enhanced results, our breakthrough Vitality ↑® NAD+ Booster takes supplementation to the next level by combining a clinically proven NAD+ precursor with synergistic ingredients. The strategic inclusion of creatine monohydrate helps stabilize cellular energy systems, while D-ribose and nicotinamide work together to optimize NAD+ synthesis pathways.

This unique formulation has been shown to increase NAD+ levels more effectively than single-ingredient supplements, providing total support for your cellular health and energy production.

With these strategies in hand, you’ll be on the right track to treating NAD deficiency and promoting longevity.

SHOP NAD+ SOLUTIONS

Referenced Sources:

NAD Supplements vs IV Therapy: Which is Best?

Written by Jinfiniti Science on October 25, 2024. Posted in NAD, NAD+. No Comments on NAD Supplements vs IV Therapy: Which is Best?

If you’ve been searching for ways to supercharge your energy or combat the signs of aging, you’ve probably come across NAD (nicotinamide adenine dinucleotide).

But here’s the real question: Should you take it as a supplement or opt for the more intensive IV therapy?

In this article, we’ll discuss:

The key differences between NAD supplements and NAD IV therapy.
The pros and cons of each option to find out which method fits best with your lifestyle and health goals.
Why some methods of NAD delivery are more effective than others and how absorption plays a crucial role.
How to tailor your NAD supplementation using personalized testing to match your unique health needs.

What is NAD?

NAD is a vital molecule found in every living cell of the human body. It serves as a coenzyme, meaning it assists enzymes in carrying out chemical reactions essential for life. NAD exists in two forms: NAD+ and NADH.

At its core, NAD+ is an electron courier. It shuttles electrons between different molecules during cellular metabolism, the process by which cells break down nutrients to generate energy.

The body produces NAD+ through three main pathways:

De novo synthesis: Creating NAD+ from scratch using amino acids.
Preiss-Handler pathway: Utilizing dietary niacin (vitamin B3) to form NAD+.
Salvage pathway: Recycling NAD+ components, primarily nicotinamide, after it has been used by enzymes.

In mammals, including humans, the salvage pathway is the primary source of NAD+. This efficient recycling process helps maintain adequate levels of this essential molecule.

NAD’s role extends beyond basic metabolism, influencing processes like DNA repair, gene expression, and cellular aging.

Types of NAD Treatments

Boosting NAD levels has become increasingly popular, and there are several types of NAD treatments available, each with its own advantages and considerations.

Oral NAD Supplements

NAD supplements come in various oral forms, including pills, capsules and pure powders. These products contain NAD precursors or related compounds designed to elevate NAD levels in the body. When ingested, a NAD+ supplement will pass through the digestive system and enter the bloodstream, where it circulates to cells throughout the body.

Many people choose oral NAD supplements as a straightforward way to increase their NAD levels. This method appeals to those who prefer to avoid intravenous treatments, offering a more familiar and less invasive approach to supplementation.

Discover Our NAD Supplements & Test Kits

NAD IV Therapy

NAD+ IV therapy is a new treatment where NAD+ is delivered directly into your bloodstream via an intravenous (IV) drip. During the session, a healthcare professional inserts a small IV line into your arm. The NAD+ solution is infused over a set period, allowing for direct absorption into your bloodstream. This bypasses the digestive system, leading to quicker availability of NAD+.

Dosages can vary depending on your needs, but typical sessions might range from 250 mg to 1,000 mg of NAD+. Treatments usually last between 1 to 3 hours, but some can go 4 hours or even longer depending on the dose and your needs. Many people opt for multiple sessions spread over weeks or months.

Other NAD Therapies

Beyond oral supplements and IV therapy, two additional methods for increasing NAD+ levels have gained some traction: injection therapy and nasal sprays.

NAD Injections

NAD+ injections offer a middle ground between oral supplements and IV therapy. This method delivers NAD+ directly into the bloodstream through intramuscular or subcutaneous injections.

NAD Nasal Sprays

NAD+ nasal sprays are a novel approach to NAD+ supplementation. These sprays deliver NAD+ through the nasal passages, claiming to deliver rapid absorption into the bloodstream.

Pros and Cons of NAD Supplements and IV Therapy

The quest for higher levels of NAD boils down to two main contenders: pills and supplements or intravenous therapy. Both have their benefits and downsides. Here we break down the pros and cons of NAD supplements versus IV drips, so you can figure out which method is best for cellular vitality.

Effectiveness

The effectiveness of NAD supplements or IV therapy depends largely on how well the body absorbs and utilizes the different delivery methods.

NAD supplements or precursors are compounds that can be efficiently taken up by cells and converted into NAD+ through various intracellular pathways. Once inside the cell, these precursors are metabolized to increase intracellular NAD+ levels. NAD precursors increase intracellular NAD+ levels by feeding into biosynthetic pathways, thereby supporting various NAD+ dependent processes.

Unlike NAD+ precursors, which are converted into NAD+ within cells, the primary action of NAD+ IV therapy is believed to be extracellular, influencing immune responses, inflammation, and cellular signaling¹ rather than directly increasing intracellular NAD+ levels.

Oral supplements are generally well-absorbed but may take longer to produce noticeable effects. In contrast, IV therapy introduces NAD+ directly into the bloodstream, resulting in more rapid onset of effects.

While IV treatments can provide a quick boost, their effects may be short-lived. This is due to several factors:

Rapid Clearance: NAD+ is quickly eliminated from the plasma, often within two hours of infusion.
Cellular Penetration: The relatively large size of NAD+ molecules can impede their ability to cross cell membranes efficiently.
Dosage Considerations: The amount and frequency of NAD+ administration significantly impact its effectiveness.

Oral NAD+ precursors offer a more consistent and sustained approach to increasing NAD+ levels. A 2019 study² demonstrated that oral supplementation can effectively elevate whole blood NAD+ levels over time:

Dose	NAD+ Increase
100 mg	22%
300 mg	51%
1000 mg	142%

These results were observed after two weeks of supplementation.

Despite its rapid clearance from the bloodstream, NAD IV therapy may still have potential benefits for certain medical conditions, particularly some neurological and infectious diseases.

To maximize the benefits of NAD+ supplementation, it’s important to consult with a healthcare provider to determine the most appropriate method and dosage regimen for individual needs and health goals.

Convenience

Supplements are generally the easier option in terms of convenience. You can take them as pills or mix a powder into a drink, making them a quick addition to your daily routine. No special setup or assistance is needed, so you can easily incorporate them into your day.

In contrast, IV therapy requires you to visit a clinic or healthcare professional. This involves scheduling an appointment and waiting, which can be less convenient if you have a busy lifestyle. The procedure typically spans several hours, during which the patient must remain relatively stationary.

The time investment for each method differs significantly:

Oral supplements: Consumption takes mere seconds
IV therapy: Sessions last between 1 to 4 hours or more

This time disparity can be a deciding factor for individuals with demanding schedules or limited flexibility in their daily routines.

In terms of availability, supplements win hands down. Oral supplements are widely available through retail stores and online platforms. IV therapy is limited to specialized clinics, which may not be present in your geographic area.

If convenience is a top priority for you, oral supplements offer a simpler, quicker, and more accessible option compared to NAD IV infusion.

Cost

Generally, dietary supplements are much more affordable. A typical bottle of NAD+ supplements can cost anywhere from $20 to $150, depending on the brand and dosage.

On the other hand, IV treatments can range from $150 to $500 per session. That can go even higher in expensive cities or at high-end clinics with state-of-the-art equipment. Add-ons like vitamins, minerals, or hydration boosters can also push up the price, so it’s worth checking what’s included before you book!

This price difference makes supplements a more accessible choice for daily or regular use. While supplements are more wallet-friendly, it’s also important to think about the long term.

If you’re considering regular IV therapy, those costs can add up quickly. For example, if you plan to have one treatment a month, that could mean spending anywhere from $1,800 to $6,000 a year.

The price disparity between these methods is substantial:

Method	Cost per Unit	Estimated Annual Cost (Monthly Use)
Oral	$20-$150/bottle	$240-$1800
IV	$150-$500/session	$1,800-$6,000

It’s essential to evaluate how often you intend to receive these treatments and whether they fit your budget in the long run. Your decision should take both immediate and ongoing expenses into account.

Safety and Side Effects

Supplements are generally safe and well tolerated, particularly in the forms of NAD precursors when taken at recommended doses. Studies have shown that they have a favorable safety profile and are relatively safe for use as a dietary ingredient³.

A study conducted in Japan found that a single oral dose of NAD precursor supplement up to 500 mg is safe for healthy men. Researchers observed no significant changes in vital signs like heart rate, blood pressure, or body temperature.⁴

However, for some individuals, they can experience common side effects like muscle pain, fatigue, sleep disturbances, and headaches⁵. These symptoms are usually short-lived and resolve quickly.

IV therapy, while highly effective for certain conditions, also carries additional risks.⁶ Patients may experience pain, bruising, or swelling at the site of infusion. Some individuals have reported additional NAD IV therapy side effects that impact the entire body, including headaches, fatigue, and nausea. These reactions can differ in intensity from person to person.

In rare cases, IV therapy can lead to serious complications, like infections or allergic reactions⁷.

Additionally, NAD IV therapy has been linked to higher levels of high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation. Our research has found that about 70% of people who receive NAD IV therapy experience a 3- to 10-fold increase in hs-CRP levels, which can trigger an inflammatory response in some individuals.

Elevated hs-CRP levels are assoicated with an increased risk of cardiovascular (CV) events and atherosclerosis⁸. Therefore, monitoring hs-CRP levels and finding effective ways to manage inflammation is crucial for keeping patients safe during and after treatment.

Before starting either treatment, it’s also important to consider contraindications. Certain medical conditions can also make these therapies unsuitable.

Also, keep in mind that age can play a role. Older adults might respond differently due to various health issues or changes in metabolism. If you’re pregnant or breastfeeding, it’s also important to consult your healthcare provider as well, since the effects of NAD therapies in these cases aren’t fully understood yet.

Always take the time to discuss any new supplements or therapies with your healthcare provider. They can help ensure that whatever you choose is a safe fit for your individual health needs and circumstances.

Staying informed and cautious is key!

Choosing Between NAD Supplements or IV Therapy

NAD supplements provide a convenient and accessible method for long-term NAD support. These supplements are typically taken daily and can be easily integrated into existing routines. Clinical data suggests that oral NAD precursors can effectively raise intracellular NAD levels over time.

Benefits of NAD Supplements:

Can increase intracellular NAD+
Convenience of at-home use
Lower cost compared to IV therapy
Suitable for long-term, consistent use
Minimal risk of complications

Considerations:

Slower onset of effects
Potential for reduced bioavailability due to digestive processes

IV NAD therapy delivers NAD directly into the bloodstream, bypassing the digestive system. This method allows for rapid absorption and potentially higher bioavailability.

Benefits of NAD IV Therapy:

Rapid onset of effects
May be beneficial for acute conditions or rapid recovery

Considerations:

Requires clinical administration
Higher cost per treatment
Time-intensive procedure
Potential for adverse reactions
Influences signaling and metabolism outside the cell

The decision between oral supplements and IV therapy should be based on individual health needs, goals, and practical considerations.

Oral Supplements May Be Preferable For:

General wellness and anti-aging support
Long-term NAD maintenance
Those seeking a cost-effective, convenient option

IV Therapy May Be More Suitable For:

Individuals with acute health concerns requiring rapid intervention
Those with conditions affecting nutrient absorption
Athletes or individuals recovering from intense physical exertion

In some cases, a combination approach may be beneficial. For example, initiating treatment with IV therapy rapid delivery of extracellular NAD+, followed by oral supplementation to increase intracellular NAD+ levels and provide sustained benefits.

If you’re unsure about your current NAD levels, our intracellular NAD test can provide valuable insight and help you tailor your approach. Understanding your NAD status can guide your decision on whether to start with supplements, IV therapy, or a combination of both.

TEST YOUR NAD LEVELS TODAY

Frequently Asked Questions

What are the benefits of NAD supplements?

NAD supplements offer potential long-term health benefits. NAD precursors have been shown to boost cellular energy production and support the body’s repair mechanisms. Research suggests they may contribute to slowing certain aspects of biological aging.

Are NAD Supplements as Effective as IV?

NAD+ IV therapy offers potential benefits for individuals with conditions like dementia, addiction, Lyme disease, and long COVID. This treatment delivers a high dose of NAD+ directly into the bloodstream, providing rapid but short-term relief. However, the effects are temporary, and the therapy requires administration by healthcare professionals in clinical settings.

For long-term benefits, including improved energy, performance, and longevity, intracellular NAD+ levels need to be increased. Oral NAD+ precursor supplements, available in pill or powder form, offer a more practical and sustainable approach. These supplements can be easily incorporated into daily routines and are designed to boost intracellular NAD+ levels over time.

Who should avoid or take NAD supplements?

Aging adults might find these supplements helpful as NAD levels naturally decline with age, potentially supporting cellular energy production and DNA repair. Athletes and fitness enthusiasts may be drawn to NAD’s role in energy metabolism, which could enhance physical performance and recovery. Individuals with specific health concerns, such as conditions linked to mitochondrial dysfunction or metabolic disorders, might also benefit from NAD supplementation.

However, certain groups should exercise caution. Pregnant or nursing women should avoid NAD supplements due to limited research on their effects during pregnancy and lactation, unless directed by a healthcare provider. Individuals with liver disease, kidney problems, or certain types of cancer should consult their doctor before use, as these supplements may interact with their condition or treatment.

Discover our NAD test kit to determine your levels and personalize your supplementation.

Discover Your NAD+ Levels with Jinfiniti

Curious about your NAD+ levels?

Jinfiniti offers an easy way to find out where you stand.

Understanding your NAD+ status can help you tailor your health approach, whether you’re aiming for energy boosts, better recovery, or overall wellness.

Our testing process is simple and provides valuable insights that can inform your next steps, whether you choose supplements, IV therapy, or both.

Discover your NAD+ levels with Jinfiniti today and discover your way to a more vibrant life. Knowing your body’s needs is the first step toward optimizing your health journey!

Referenced Sources:

How to Increase NAD+ Levels Naturally

Written by Jinfiniti Science on October 22, 2024. Posted in NAD, NAD+. No Comments on How to Increase NAD+ Levels Naturally

While its name may be complex, its importance to human health is crystal clear.

NAD+ (nicotinamide adenine dinucleotide) is one of the most important molecules in your body, present in every living cell. This remarkable compound stands at the center of cellular health, driving the fundamental processes that keep you alive and thriving.

Unfortunately, our NAD+ levels follow a predictable pattern – they steadily decline as we get older. This decline isn’t just a number on a chart; it’s one of the key reasons our bodies show signs of aging.

When NAD+ drops, it’s like having fewer batteries to power our cellular devices, leading to slower repairs and decreased efficiency throughout the body.

There is, however, a silver lining: science has revealed several natural ways to maintain healthy NAD+ levels.

Understanding and supporting your body’s NAD+ production can help your cells stay energized and resilient – essentially giving them the tools they need to function at their best.

In this article, we discuss…

The indispensable role NAD+ plays in supporting health and longevity
Factors beyond aging that contribute to the decline in NAD+ levels
Natural strategies to optimize your NAD+ levels
The single most effective way to increase NAD+ alongside a healthy diet, exercise, and proper nutrition

Understanding the Importance of NAD+

NAD+ is a fundamental molecule present in all living cells that serve as a critical link in cellular metabolism. This coenzyme plays a dual role: it facilitates the conversion of nutrients into cellular energy and acts as an essential signaling molecule in various biological processes¹.

At the cellular level, NAD+ is integral to energy production within mitochondria², where it helps convert carbohydrates, fats, and proteins into adenosine triphosphate (ATP) – the universal energy currency of cells.

Beyond energy metabolism, NAD+ is fundamental for maintaining genomic stability through DNA repair mechanisms³ and regulating inflammatory responses.

The significance of NAD+ becomes particularly apparent as its levels naturally decline with age. This decrease correlates with several physiological changes: reduced energy production, diminished cellular repair capacity, and altered metabolic function.

Research has linked insufficient NAD+ levels to various age-related conditions⁴, including metabolic disorders, neurodegenerative diseases, and compromised immune function⁵.

The cellular consequences of NAD+ decline manifest in observable effects on health and vitality. When NAD+ levels are adequate, cells maintain optimal energy production and repair capabilities.

Conversely, decreased NAD+ availability can lead to reduced metabolic efficiency⁶ and compromised cellular maintenance, potentially accelerating age-related cellular deterioration.

To put it concisely, having optimized NAD+ levels can support anti-aging efforts, reduce inflammation, and sustain energy levels throughout life.

The Causes of NAD+ Decline

Aging is one of the biggest factors behind the decline in NAD levels⁷, resulting from a series of interconnected biological mechanisms

For instance, DNA damage triggers enzymes like PARPs to repair cells⁸, consuming NAD+ in the process. Additionally, age-related inflammation (inflammaging) activates NAD-depleting enzymes like CD38⁹, which break down NAD+ during immune responses.

Mitochondrial dysfunction also worsens with age¹⁰, demanding more NAD+ to maintain energy production. Simultaneously, the efficiency of NAD+ synthesis declines as key enzymes, such as NAMPT, become less effective¹¹.

Furthermore, oxidative stress and the accumulation of senescent cells¹², which consume NAD+ and drive chronic inflammation, exacerbate this decline. Reduced NAD+ availability impairs the function of sirtuins, proteins vital for aging and metabolic regulation, creating a feedback loop that accelerates NAD+ depletion.

All these factors contribute to the age-related decline in NAD+ levels, impacting cellular health and energy production.

Aside from aging, excessive exposure to UV rays can also damage cells and speed up NAD+ depletion¹³. UV radiation triggers oxidative stress, which not only reduces NAD+ levels but also weakens the body’s ability to repair itself.

Drinking alcohol can also interfere with the body’s ability to maintain healthy NAD+ levels¹⁴. This is because the liver uses up a large amount of NAD+ to detoxify alcohol, which leaves less of it for other important functions around the body.

Chronic inflammation, whether from conditions like arthritis or autoimmune disorders, also accelerates NAD+ decline¹⁵. Inflammation causes oxidative stress, which depletes NAD+ and compromises its role in repairing damaged cells.

Natural Ways to Boost NAD Levels

If you’re feeling fatigued, recovering more slowly, or noticing other signs of NAD+ deficiency, you may be looking for ways to increase NAD levels naturally. Combining lifestyle adjustments with evidence-based approaches that support NAD+ production will help you increase your energy, enhance recovery, and improve your overall health.

Dietary Approaches

Your food choices play a role in maintaining healthy NAD levels.

Eating foods rich in NAD+ precursors¹⁶, like vitamin B3 (niacin), tryptophan, and fermented foods, can help support NAD+ production. These foods help by providing your body with the essential building blocks to synthesize NAD+.

Niacin, found in foods like turkey, chicken, and fish, can offer a helping hand in NAD+ synthesis. Tryptophan, present in eggs, nuts, whole grains, cow’s milk, and dairy, is another nutrient that can be converted into niacin, further increasing your levels of NAD.

Fermented foods like kimchi, sauerkraut, and kombucha promote gut health, which can indirectly support NAD+ production. Fermented foods contain very small amounts of NAD+ as a byproduct of the fermentation process.

Moreover, eating healthy fats from sources like avocados, olive oil, and fatty fish provides the nutrients needed to support cellular function and energy production, helping to support your NAD+ levels naturally.

Exercise and Physical Activity

Regular exercise protects against the decline in skeletal muscle NAD content associated with aging¹⁷.

Physical activity not only helps maintain NAD+ but contributes to regulating oxidative stress¹⁸, which is vital for maintaining energy levels and overall cellular health.

Aerobic exercise, such as running, cycling, or swimming, increases oxygen flow to your cells, promoting mitochondrial function and reversing age‐dependent decline in NAD+ salvage capacity¹⁹.

Interval training, where you alternate between high-intensity bursts and low-intensity recovery, has also been shown to increase the levels of NAD by enhancing metabolic processes efficiency and stimulating sirtuins—proteins that depend on NAD+ for cellular health²⁰.

Lifestyle Changes

Lifestyle changes, such as calorie restriction, intermittent fasting, and managing stress, can also help regulate NAD levels.²¹

Calorie restriction and intermittent fasting promote a process called autophagy²², which helps the body clear out damaged cells and regenerate new ones, helping stimulate NAD+ production and supporting cellular repair.

Additionally, adopting a ketogenic diet, which is high in healthy fats and low in carbohydrates, can help improve metabolic efficiency, further promoting NAD+ synthesis.

Stress management techniques such as meditation, yoga, and deep breathing also help reduce oxidative stress²³, which can otherwise deplete NAD+ levels.

Finally, getting quality sleep can help maintain healthy NAD+ levels. During deep sleep, the body undergoes restorative processes that require NAD+ to function optimally²⁴, including the activation of sirtuins.

Poor sleep or insufficient rest disrupts these processes, leading to increased oxidative stress and inflammation, which deplete NAD+ levels over time.

Restful sleep also helps regulate the circadian rhythm, which influences NAD+ metabolism²⁵. Maintaining a regular sleep schedule is therefore important for sustaining healthy NAD+ levels.

Heat Exposure

When the body is exposed to heat, it activates a response known as heat shock, which triggers the production of heat shock proteins that assist in repairing damaged cells and maintaining cellular health. This process induces an increase²⁶ in the NAD+/NADH ratio.

Regular use of saunas or hot baths has also been linked to increased longevity, improved circulation, and better mitochondrial function, all of which are important for maintaining healthy NAD+ levels.

Additionally, heat promotes better circulation by causing blood vessels to dilate, improving the delivery of oxygen and nutrients, including NAD+ precursors, to cells. This enhanced blood flow supports cellular energy and repair.

Regular sauna use has been shown to reduce inflammation, a major factor in aging, which helps prevent the depletion of NAD+ by reducing the activity of enzymes that break it down.

Together, these factors—improved circulation, mitochondrial function, reduced inflammation, and enhanced cellular repair—contribute to sustaining healthy NAD+ levels, supporting longevity and cellular health.

Supplements to Increase NAD Levels

To effectively boost NAD levels naturally, evidence-based supplementation should be paired with the key lifestyle changes outlined above. Research shows that targeted NAD supplementation, when paired with healthy daily habits, can address low levels of NAD and support your overall metabolic health.

Oral NAD+ supplements are one of the most popular and accessible ways to boost NAD+ levels. These often come in the form of sublingual NAD powder or capsules that contain NAD precursors, which are clinically proven to increase intracellular NAD levels.

NAD precursors include D-Ribose and Nicotinamide, which work synergistically to raise NAD levels.

Nicotinamide, a form of vitamin B3, serves as a direct precursor to NAD+ through the salvage pathway²⁷. It is converted to nicotinamide mononucleotide (NMN) by the enzyme nicotinamide phosphoribosyltransferase (NAMPT), and then to NAD+ by nicotinamide mononucleotide adenylyltransferases (NMNATs)²⁸.

D-Ribose enhances this process by stimulating NADPH production via the pentose phosphate pathway. NADPH is crucial for converting oxidized NAD+ back to its reduced form, NADH, thus maintaining the NAD+ pool. D-ribose may also improve the efficiency of nicotinamide utilization by providing the ribose sugar component needed for NAD+ synthesis.

Some supplements combine various NAD+ precursors like nicotinamide riboside (NR) with other compounds like resveratrol or pterostilbene, which may improve NAD+ metabolism or provide synergistic benefits.

Our Vitality ↑® NAD+ Booster is a clinically validated formulation consisting of NAD precursor, Creatine monohydrate, D-Ribose and Nicotinamide, four key compounds that work together to help maintain healthy levels of NAD+. While the effectiveness of NAD+ supplementation continues to be studied, each component in our formula has been individually researched for its role in cellular energy processes.

SHOP NAD+ BOOSTER

Advanced NAD Therapies

Advanced therapies for increasing NAD+ levels in the body include intravenous (IV) infusion and subcutaneous injection. Each method has distinct characteristics that influence its effectiveness and application.

NAD+ IV therapy delivers the compound directly into the bloodstream, bypassing the digestive system. This enables rapid uptake and immediate availability throughout the body’s tissues. Healthcare providers typically recommend this approach for addressing acute conditions like severe fatigue or for intensive therapeutic protocols.

Subcutaneous administration involves injecting NAD+ into the layer of tissue just beneath the skin. This creates a depot effect, where the compound is gradually released into circulation over an extended period.

These therapies require medical supervision and careful consideration of cost-benefit factors, including the price tag and potential side effects of NAD therapy. Medical screening and ongoing monitoring are essential, as these therapies may not be suitable for all individuals or medical conditions.

How to Monitor Your NAD Levels

Monitoring your NAD+ levels is important for understanding how well your body is maintaining energy and supporting cellular health.

The Intracellular NAD® Test measures NAD+ concentrations directly within cells, providing a precise assessment of your cellular NAD+ status. This measurement helps evaluate how lifestyle factors, dietary changes, and supplementation influence your cellular metabolism.

By establishing your baseline NAD+ levels before beginning any intervention, you can objectively track changes over time. Our research indicates that intracellular NAD+ concentrations of 40 micromoles (µM) or higher are associated with optimal cellular function. Regular monitoring enables evidence-based adjustments to supplementation protocols when needed.

Maintaining adequate NAD+ levels supports fundamental biological processes:

Mitochondrial energy production
Cellular stress response
DNA maintenance and repair
Metabolic regulation

While individual responses vary, optimizing NAD+ levels typically promotes cellular resilience and helps maintain metabolic function as you age. Regular testing provides actionable data to guide personalized interventions aimed at supporting cellular health.

TEST YOUR NAD LEVELS TODAY

Test Your NAD Levels with Jinfiniti

Is your NAD level where it should be?

Jinfiniti’s Intracellular NAD Test gives you an accurate measure of your NAD+ levels and shows how they impact your health.

Testing your NAD levels both before and after supplementation helps you find the right dosage for your body, as what works for one person may not be effective or could even be harmful to someone else.

With data from your NAD test, you can fine-tune your supplementation to get the maximum benefit and avoid over- or under-supplementing.

Jinfiniti’s NAD test gives you more than just numbers—it shows you what your body needs, helping you make better choices and optimize your health for improved vitality and longevity.

Referenced Sources:

NAD IV Therapy Side Effects: What are the Risks?

Written by Jinfiniti Science on October 18, 2024. Posted in NAD+. No Comments on NAD IV Therapy Side Effects: What are the Risks?

NAD IV therapy promises incredible results, from boosting energy to supporting anti-aging.

But is it too good to be true?

While the benefits sound great, there are common side effects of NAD therapy, from minor discomfort to serious complications, that you shouldn’t ignore.

Are the risks really worth it?

In this article, we’ll dive into:

The hidden safety concerns and side effects of NAD IV therapy that most people don’t talk about.
Critical factors you should consider before deciding if NAD IV therapy is right for you.
A safer alternative to NAD IV therapy that delivers results more efficiently without the downsides.

Recent studies show that by middle age, your NAD levels may drop to half of what they were in your youth¹. This decline can impact everything from your energy to how quickly you recover from stress.

It’s no surprise that NAD IV therapy has been gaining popularity as a quick fix for restoring vitality and slowing down the aging process. But with any growing trend comes important questions, particularly around safety.

Is NAD IV therapy as risk-free as it sounds? While the claims are exciting, it’s important to look at both sides, hence we’ll also dig into the risks and side effects in this article.

What is NAD IV Therapy?

Imagine having a “battery” in every cell of your body, constantly fueling your energy, repairing DNA, and keeping everything functioning smoothly. That’s the role of NAD (Nicotinamide Adenine Dinucleotide), a coenzyme essential for cellular health.

As we age, our NAD levels start to dip, leaving many of us feeling fatigued, recovering more slowly, and even noticing changes in our mental clarity.²

That’s where NAD supplementation comes into play, with many people turning to NAD IV therapy to help recharge those cellular “batteries.” NAD IV therapy involves infusing NAD directly into your bloodstream through an IV drip, bypassing the digestive system for quicker, more efficient absorption. The treatment typically lasts around four hours or longer, allowing the NAD to enter your body slowly while you relax.

Advocates of NAD IV swear by its benefits: increased energy, sharper focus, improved mood, and even anti-aging effects. Some even say it aids in addiction recovery, boosts athletic performance, and helps with cellular repair.

Common Safety Concerns of NAD Therapy

While many people report positive experiences with NAD IV treatment, there are some risks to consider, especially if the treatment isn’t administered properly, including:

Infection

Any time you’re dealing with an IV, there’s a risk of infection.³

Since the skin is punctured, bacteria can enter your bloodstream if the equipment isn’t properly sterilized. To reduce this risk, it’s important to have the treatment administered by trained professionals in a clean, medical setting.

Vein Irritation

Some people experience irritation or inflammation around the injection site.⁴

This could be due to the needle size, the frequency of treatments, or simply how your body reacts to the IV. While it’s usually minor and resolves on its own, it can still be uncomfortable.

Incorrect Dosage

Getting the dosage right with NAD IV therapy is crucial. Too little, and you may not experience the full benefits. Too much, and you could feel nauseous or dizzy.

A qualified practitioner will know the correct dosage for your body and specific needs.

Improper Administration

IV therapy requires precision. The placement of the IV, the dosage, and the flow rate all need to be exactly right.

If the person administering the treatment lacks experience, things can go wrong. You could end up with a poorly inserted IV or air bubbles in the line, which could lead to complications.⁵

Quality and Sourcing of NAD Products

Not all NAD products are created equal. The quality and purity of the NAD solution being used are vital to ensure you get the best results with minimal risk.

It’s important to choose a clinic that uses high-quality NAD sourced from reputable suppliers. If you’re given an inferior product, you could miss out on the benefits—or worse, face unwanted side effects.

What are the Side Effects of NAD IV Therapy?

Like any treatment, NAD IV therapy can come with its own set of side effects. While they’re usually mild, it’s important to be aware of what you might encounter during or after your session.

Common Short-Term Side Effects

Most people who try NAD IV therapy report mild side effects that tend to go away quickly. These can include nausea, flushing, and dizziness during or shortly after the treatment.

Some also report muscle cramping or chest tightness as the body adjusts to the NAD infusion. Though these milder symptoms typically fade after the session, they can be uncomfortable while they last.

Possible Long-Term Side Effects

While NAD IV therapy shows promise, there are concerns about its long-term effects, especially with frequent or high-dose intravenous treatments.

Flooding the body with excessive NAD, sometimes up to ten times the normal range, could disrupt its natural balance. This is a particular concern with unregulated IV bars, where dosage and frequency may not be carefully monitored.

While NAD+ is vital for various cellular processes, excessively high levels of NAD+ could potentially lead to adverse effects such as mitochondrial dysfunction or sirtuin overactivation.

NAD IV therapy has also been observed to cause a significant increase in high-sensitivity C-reactive protein (hs-CRP) levels in a substantial portion of recipients. Specifically, about 70% of individuals undergoing NAD IV therapy experience a 3- to 10-fold increase in hs-CRP, which is an acute phase reactive protein that indicates inflammation. To safeguard patient well-being, it is recommended to monitor hs-CRP levels and implement effective strategies to control inflammation.

If you are concerned about levels of inflammation, our at-home inflammation test kit, the AgingSOS® Senescence & NAD Panel, can help you reveal your inflammation status and take appropriate action.

AgingSOS® Senescence & NAD Panel

The Safest Approach to NAD IV Therapy

If you’re considering NAD IV therapy, safety should be your top priority. Here are a few key steps to ensure a safe and effective experience:

Choose a Qualified Provider

Your first step should be finding the right provider. Look for a licensed and experienced practitioner who specializes in NAD IV therapy.

Ask about their qualifications, experience with NAD treatments, and the safety protocols they follow. A reputable provider will gladly answer your questions and ensure you feel comfortable before moving forward.

Evaluate Your Health

Before starting any NAD IV therapy, it’s crucial to get a thorough health evaluation. Your provider should review your medical history, current medications, and any existing health conditions.

This helps determine whether NAD therapy is safe for you and allows them to tailor the treatment to your specific needs. Skipping this step could increase the risk of complications.

Monitor Your NAD Levels Regularly

To get the most out of NAD IV therapy and minimize risks, it’s also important to monitor your NAD levels.

The most effective way to do this is using an Intracellular NAD test, which measures the NAD levels within your cells. Keeping track of these levels during and after your sessions helps avoid issues like overdosing or underdosing.

This ongoing evaluation allows your practitioner to adjust your treatment for optimal results.

Test Your NAD Levels Today

Oral NAD Supplements: A Safer Alternative to NAD IV Treatment

While NAD IV therapy is popular for its quick delivery, it’s not the only option for boosting NAD levels. In fact, many people opt for an oral NAD+ supplement due to safety and convienience.

One big difference is how they work.

NAD IV therapy directly introduces the coenzyme into the bloodstream, but it is quickly metabolized and excreted, resulting in a short-lived effect.

Oral supplements, such as sublingual NAD powder, get absorbed by your cells and work from the inside out, helping to increase your body’s NAD+ levels gradually and sustainably. Plus, they’re much easier on the wallet and your schedule.

NAD IV can be both pricey and time-consuming, often costing hundreds per session and taking up to four hours or even more. In contrast, supplements are way more budget-friendly and easy to take, whether you’re at home or on the move. They fit right into your daily routine without any hassle.

Discover Our NAD Optimization® Supplements

Final Thoughts: Is NAD IV Therapy Safe?

NAD IV therapy has its benefits, but it’s not without risks. You might experience mild side effects like nausea or dizziness, or more serious issues like infections.

Safety is a big deal, especially if you’re thinking about using it long-term. It’s important to weigh these risks and talk to a qualified provider about whether it’s right for you. Take your time to weigh the pros and cons and find out if it suits your needs.

Also, don’t overlook safer alternatives like oral supplements. They work at the cellular level, naturally boosting NAD without the risks tied to IV treatments.

They also offer a more consistent, long-term boost, fueling your energy and overall health. Plus, you can take them anywhere, anytime, making them a hassle-free part of your daily routine.

So, if you’re seeking an effective, low-risk option to optimize your NAD levels and overall well-being, oral supplements may just be the better choice.

The best part? You can start today—without the needles or lengthy appointments.