Author: Jinfiniti Science

Bottle of Niacin Beside a Jar of Niacinamide Cream

NAD vs Niacin vs Niacinamide: Vitamin B3 Differences Decoded

Written by Jinfiniti Science on December 21, 2024. Posted in NAD+, NAD+ Precursors, Niacin, Nicotinamide, Vitamin B. No Comments on NAD vs Niacin vs Niacinamide: Vitamin B3 Differences Decoded

The vitamin B3 on your supplement label hides a deeper truth.

What appears as a single nutrient actually represents a family of compounds—each following its own path through your cellular machinery.

Understanding the difference between NAD, niacin, niacinamide, and nicotinamide isn’t just biochemistry—it’s the key to unlocking specific health benefits while avoiding unwanted effects.

Let’s decode what your supplement label doesn’t tell you about the forms of vitamin B3.

Vitamin B3: A Short History

In 1937, Conrad Elvehjem made an accidental discovery that would reshape our understanding of human health. While studying black tongue disease in dogs, he isolated a compound that not only cured the canine condition but also proved to be the key to solving pellagra—a devastating human disease that had claimed thousands of lives across the American South.

That compound was niacin, but it was just the beginning. What started as a single vitamin has evolved into a complex family of molecules. Modern longevity researchers have transformed B3 from a simple nutritional supplement into a cornerstone of aging research, with different forms of the vitamin showing distinct effects on cellular health, energy production, and DNA repair.

Is NAD More Than Just Another B3?

A healthy woman smiling, aging gracefully

NAD or nicotinamide adenine dinucleotide stands apart from other B3 vitamins—it’s not a form of B3, but rather a critical coenzyme your cells use as currency in energy transactions. We can think of NAD as cellular currency: every metabolic purchase your cells make requires NAD+, from breaking down glucose¹ to repairing damaged DNA².

But here’s where it gets interesting: despite NAD+’s fundamental role, you can’t simply swallow it as a supplement. The molecule is too large and unstable to survive digestion³. Your body must build its NAD+ supply from smaller B3 building blocks—each with its own efficiency rating in the conversion process.

The connection between NAD+ and aging emerged when scientists discovered that our NAD+ levels plummet as we get older. This decline correlates with many hallmarks of aging: decreased energy production, impaired DNA repair, and reduced cellular resilience. Restoring NAD+ levels has become a central focus in longevity research.

Let’s break down the family of B3 compounds and their relationship to NAD+:

B3 Form	Conversion to NAD+	Key Benefits	Sources
Niacin (Nicotinic Acid)	3-step process, moderate efficiency	Cardiovascular health, cholesterol management	Food sources, immediate-release supplements
Niacinamide (Nicotinamide)	2-step process, good efficiency	Skin health, joint function	Supplements, fortified foods, skincare products
Nicotinamide Riboside (NR)	2-step process, high efficiency	NAD+ boosting, cellular energy	Specialized supplements

What is Niacin? The Original B3

Niacin—known chemically as nicotinic acid—remains the most thoroughly studied form of vitamin B3. Its simple molecular structure belies its power: a six-member ring with a carboxylic acid group that gives this compound its distinctive properties.

You’ll find niacin throughout the natural world. It’s abundant in meat, fish, and nuts, with mushrooms and avocados providing substantial plant-based sources. Unlike other B3 forms, it announces its presence in your body with an unmistakable sensation.

The infamous “niacin flush” stands as both blessing and curse. Within 30 minutes of taking higher doses, your skin turns red and warm—a temporary but often intense experience that feels like a sunburn. This flush isn’t dangerous—it’s actually a sign of niacin expanding your blood vessels, the same mechanism behind its cardiovascular benefits⁴.

Beyond circulation, niacin shows remarkable effects on blood lipids that other B3 forms can’t match. It’s the only B3 variant proven to both lower harmful LDL cholesterol and raise beneficial HDL cholesterol⁵. This unique property has kept niacin relevant in an era of more exotic B3 derivatives.

Niacinamide vs Nicotinamide

The supplement industry’s cleverest marketing trick lies in making two identical molecules seem different. Niacinamide and nicotinamide are perfect chemical twins—same structure, same effects, same molecule.

This dual naming stems from historical quirks in scientific nomenclature. While researchers prefer “nicotinamide,” the cosmetics industry adopted “niacinamide”—creating an illusion of distinction that persists in marketing materials and product labels.

The truth? Both names describe a modified form of B3 where the carboxylic acid group of niacin has been replaced with an amide group. This small change eliminates the flush reaction while opening new therapeutic doors. Your skin cells particularly love this form of B3—they readily absorb it and use it to repair UV damage, reduce inflammation, and regulate oil production⁶.

The benefits extend beyond skincare. Whether labeled niacinamide or nicotinamide, this form of B3 supports joint health, aids cellular repair, and helps maintain DNA integrity—all without the circulation-related effects of standard niacin.

Nicotinamide Riboside and Nicotinamide Mononucleotide

A common misconception clouds the NAD+ precursor landscape: while Nicotinamide Riboside (NR) belongs to the B3 family, Nicotinamide Mononucleotide (NMN) does not. NMN represents the next step in the NAD+ production pathway—a larger, more complex molecule that sits between B3 vitamins and NAD+ itself.

When comparing NMN and NR, both compounds share a singular purpose: boosting NAD+ levels. But they take different routes to this destination. NR enters cells directly through specialized transporters, while NMN must either convert to NR before absorption or use recently discovered transport mechanisms. This distinction has sparked intense debate in the research community about their relative effectiveness.

The scientific evidence paints a nuanced picture. Clinical trials show both molecules can increase NAD+ levels, with participants reporting improved energy, better sleep quality, and enhanced exercise performance. Studies on safety and side effects for both compounds are encouraging—NR has demonstrated a strong safety profile across multiple long-term trials⁷, while NMN has shown excellent tolerability in human studies⁸, with research continuing to expand our understanding of both molecules.

Recent research has uncovered tissue-specific preferences for these molecules⁹. Some organs appear to utilize NR more efficiently, while others show stronger responses to NMN. This finding suggests that the “best” NAD+ precursor might depend on your specific health goals and target tissues.

Choosing a B3 Supplement

Woman's perspective, hands holding a glass of water with a B3 supplement

Selecting the right B3 supplement demands a strategic approach based on your health objectives and biochemical needs. The form you choose defines not just the benefits you’ll receive, but also how your body will respond to the supplement.

Your supplementation strategy should align with specific health goals:

For cardiovascular health and lipid management: Standard niacin remains the gold standard, though the flush reaction requires careful dose titration. Start with 100mg and gradually increase to assess tolerance.
For skin health and inflammation: Choose products containing niacinamide (nicotinamide), particularly in concentrations between 2-10% for topical applications. Look for formulations free of potential irritants.
For cellular energy and longevity support: NAD+ precursors offer the most direct path. Modern research points to combination approaches that support multiple aspects of cellular energy production.

When evaluating NAD+ precursor supplements, look beyond basic formulations. The most effective products combine precursors with synergistic compounds that support cellular energy metabolism—a strategy backed by emerging research.

The Vitality ↑® NAD+ Booster exemplifies this advanced approach. Combining NAD precursors NMN and nicotinamide with cellular energy enhancers Creatine monohydrate and D-Ribose, our NAD precursor powder supports both NAD production and overall energy metabolism. This clinically-validated formulation addresses the complex nature of cellular energy production.

Before starting any B3 supplementation:

Consult healthcare providers if you take medications, particularly diabetes drugs or statins
Choose morning supplementation for most forms, except when using niacin (which some prefer at night to sleep through the flush)
Store your supplements in cool, dry places—NAD precursors particularly benefit from proper storage
Look for third-party testing certification and clear ingredient labeling
Consider cost per effective dose rather than just price per bottle

The right B3 supplement can transform your cellular health—but only when chosen with purpose and used with understanding. Your investment in B3 supplementation should match your health goals, backed by science and quality manufacturing.

SHOP NAD+ BOOSTER

Referenced Sources

What Are Sirtuins and What Is Their Role in Aging?

Written by Jinfiniti Science on December 20, 2024. Posted in NAD+, NAD+ Precursors, Premature Aging. No Comments on What Are Sirtuins and What Is Their Role in Aging?

Aging is inevitable, influenced by genetics, lifestyle, and the environment. At the cellular level, changes like DNA damage, reduced energy production, and rising inflammation drive aging. The good news is, science has uncovered some fascinating ways to understand and possibly slow down the process.

Among the most exciting discoveries involves sirtuins, a family of proteins that help how our bodies handle aging. They regulate metabolism, protect DNA, and manage oxidative stress to keep our cells functioning properly.

What makes sirtuins particularly intriguing is their connection to NAD+, a molecule that’s critical for their function. Unfortunately, NAD+ levels drop as we get older, limiting sirtuins’ ability to protect our cells from damage.

However, research shows that boosting NAD+ levels through supplements, exercise, and other strategies can reactivate sirtuins to help combat age-related decline. This makes understanding sirtuins an important piece in the puzzle of aging and optimizing health.

In this article, we’ll discuss:

Why NAD+ is a cofactor for sirtuins and how boosting NAD+ levels can increase sirtuin activity and combat aging.

The fascinating role of sirtuins in regulating metabolism, DNA repair, and cellular stress, and how they contribute to longevity.

The science behind caloric restriction and how it activates sirtuins to improve lifespan and overall health.

What are Sirtuins?

Sirtuins are a family of seven evolutionarily conserved proteins (SIRT1-7) that act as cellular regulators, earning them the nickname “guardians of the genome” for their multifaceted roles in metabolism, gene expression, and cellular health. They depend on a molecule called nicotinamide adenine dinucleotide (NAD+) to do their job and carry out molecular functions.

Specifically, sirtuins belong to a family of NAD+-dependent enzymes called histone deacetylases,¹ which modify both DNA-packaging proteins and many other cellular proteins. Through their deacetylation activity – removing acetyl groups – sirtuins function as molecular switches that control gene expression, metabolism, stress responses, and cellular aging by responding to the cell’s energy state.

The discovery of sirtuins is rooted in the study of aging. Scientists first identified a sirtuin protein in yeast, called Sir2,² while investigating the genetic factors that influence lifespan. They found that under conditions of caloric restriction, Sir2 activity increased, leading to a 30%–40% increase in lifespan.³ This discovery sparked interest in sirtuins and their potential role in longevity.

Sirtuins act as important energy status sensors and regulators of metabolism. They respond to changes in cellular energy levels, particularly through their sensitivity to NAD+ levels, which fluctuate based on the nutritional state of the cell.

Sirtuins help control metabolic flexibility, or how your body switches between burning carbohydrates and fats:

Carbohydrate metabolism: When you’re not eating, sirtuins (specifically SIRT1) help regulate blood sugar in two phases. Initially, they reduce sugar production, but during longer fasting periods, they activate genes that help maintain stable blood sugar levels.⁴

Lipid metabolism: Sirtuins also help your body use stored fat for energy when food is scarce. They do this by turning on genes that break down fat while turning off ones that store it.

This flexibility is important for adapting to times of limited food intake or intense physical activity, such as during workouts.

One of sirtuins’ most important functions is maintaining genome stability through DNA repair mechanisms.⁵ When cells encounter DNA damage from environmental stressors like UV radiation, pollution, or normal metabolic processes, sirtuins help coordinate the repair response. SIRT1 and SIRT6, in particular, are instrumental in recruiting DNA repair proteins and modifying chromatin structure to facilitate repair processes.

Every day, your cells encounter DNA damage from things like pollution or even normal cellular processes. Sirtuins also help repair this damage, preserving the integrity of your genetic material.⁶ Without this function, cells accumulate errors, leading to aging and age-related diseases.

Beyond DNA repair, sirtuins contribute significantly to cellular stress resistance through multiple pathways.⁷ They activate antioxidant defense systems to combat oxidative stress, regulate mitochondrial function to maintain energy balance, and modulate inflammatory responses.

When sirtuins are active, they help your body adapt to challenges, repair itself, and function more efficiently. But as we age, factors like declining NAD+ levels reduce their effectiveness. This decline leads to many age-related issues, including slower metabolism, reduced cellular repair, and increased inflammation.

Key Takeaway: Sirtuins are NAD+-dependent proteins that act as cellular regulators, managing metabolism, DNA repair, and aging processes by functioning as molecular switches that respond to cellular energy states and help maintain genomic stability.

The Sirtuin Family: Characteristics and Functions

The sirtuin family consists of seven unique proteins, SIRT1 through SIRT7. Each sirtuin has its own job to keep your body functioning optimally and protect it from the effects of aging and disease. Let’s see what makes each of these proteins so important.

Sirtuin	Location	Major Functions	Disease Associations
SIRT1	Nucleus, Cytoplasm	Metabolism regulation Stress response DNA repair Cell survival Circadian rhythm control	Type 2 diabetes, cardiovascular disease, neurodegenerative disorders, cancer
SIRT2	Cytoplasm, Nucleus	Cell cycle regulation Microtubule dynamics Glucose metabolism Inflammation control	Neurodegenerative diseases, cancer, insulin resistance
SIRT3	Mitochondria	Mitochondrial energy metabolism ROS regulation Fatty acid oxidation ATP production	Age-related hearing loss, metabolic syndrome, cancer, cardiac hypertrophy
SIRT4	Mitochondria	Amino acid metabolism Fatty acid oxidation Insulin secretion ATP homeostasis	Type 2 diabetes, cancer, metabolic disorders
SIRT5	Mitochondria	Urea cycle Cellular respiration Ketone body formation ROS management	Cancer, metabolic disorders, cardiovascular disease
SIRT6	Nucleus	DNA repair Telomere maintenance Glucose homeostasis Inflammation regulation	Aging, cancer, type 2 diabetes, cardiovascular disease
SIRT7	Nucleolus	rRNA transcription Chromatin remodeling Stress response Lipid metabolism	Cancer, cardiovascular disease, aging

SIRT1 and SIRT3: The MVPs

Among the sirtuin family, SIRT1 and SIRT3 stand out as the real power players.⁸ They are key to many processes that keep your body running efficiently and aging gracefully.

SIRT1 takes the lead in regulating metabolism⁹ and the stress response. It helps the body adapt to changes in energy availability, like during fasting or exercise, by activating pathways that promote fat-burning and energy conservation. It also manages inflammation and protects cells from oxidative damage, a common contributor to aging and chronic diseases.

What’s particularly fascinating is how SIRT1 also modulates circadian rhythms¹⁰—those 24-hour biological cycles that govern so many of our physiological processes. This circadian connection has significant implications for metabolic homeostasis, helping explain why SIRT1 dysfunction is often linked to metabolic disorders like type 2 diabetes, which are more common as we age.

If SIRT1 governs metabolism, SIRT3 is the guardian of mitochondria, those remarkable cellular organelles that power virtually every biological process in our bodies. SIRT3 optimizes mitochondrial function by regulating energy production,¹¹ controlling reactive oxygen species (ROS), and boosting antioxidant defenses. This intricate balancing act is critical because when ROS production exceeds our antioxidant capacity, the resulting oxidative stress can trigger a cascade of cellular damage that contributes to accelerated aging.

SIRT3 also supports fatty acid oxidation,¹² a process where fats are broken down for energy. It also helps preserve heart health and hearing as we age. Its protective effects on mitochondria are especially critical for organs with high energy demands, like the brain and heart.¹³

As shown in our table above, SIRT1 and SIRT3 operate in different cellular compartments (SIRT1 in the nucleus and cytoplasm, and SIRT3 in the mitochondria), but they both protect your body from the effects of aging and disease. Both help guard against neurodegenerative diseases and reduce the risk of heart-related conditions.

Key Takeaway: SIRT1 and SIRT3 protect against aging by regulating metabolism and maintaining cellular energy production in different parts of the cell.

Sirtuins and NAD+

Our understanding of sirtuins and aging comes with a critical caveat – these cellular guardians are only as effective as their fuel supply.

Sirtuins require NAD+ as an essential co-substrate to perform their deacetylation functions, and the steep decline in NAD+ levels as we age – up to 50%¹⁴ – directly impairs sirtuin activity across all seven family members. This diminishing NAD+ availability helps explain why cellular repair, metabolic efficiency, and inflammation control tend to worsen over time.

Interestingly, you can support sirtuin function by replenishing NAD+ levels.¹⁵ NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), are supplements that help restore NAD+ in the body. With their support for NAD+, these precursors effectively reactivate sirtuins, enabling them to continue protecting your cells and promoting overall health.

Sirtuins and the Aging Process

The relationship between sirtuins and aging represents one of the most fascinating areas of longevity research. As we age, our bodies experience various forms of cellular decline, from decreased energy production to accumulating DNA damage. Sirtuins contribute in either preventing or repairing these age-related changes, earning their reputation as longevity proteins.

At the molecular level, sirtuins influence aging through several key mechanisms. They help maintain genomic stability by coordinating DNA repair processes and managing chromosomal structure, with SIRT6 specifically helping to maintain telomeres¹⁶ – the protective caps at our chromosomes that naturally shorten as we age. Additionally, sirtuins regulate inflammation through multiple pathways,¹⁷ helping combat “inflammaging,” the chronic, low-grade inflammation that contributes to various age-related diseases like Alzheimer’s and dementia.

Perhaps most importantly, sirtuins influence how our cells produce and use energy. They optimize mitochondrial function, helping these cellular powerhouses produce energy more efficiently while generating fewer harmful byproducts. This is particularly significant because mitochondrial dysfunction is a hallmark of aging, contributing to everything from muscle weakness to cognitive decline.

The decline in NAD+ levels particularly affects sirtuin function, creating a vicious cycle where reduced sirtuin activity accelerates various aspects of aging, which in turn further impairs sirtuin function. This understanding has led to growing interest in interventions that can maintain or boost sirtuin activity with age, from NAD+ supplementation and sirtuin activators to exercise, opening exciting possibilities for promoting healthier aging through targeted interventions.

Key Takeaway: Sirtuins are master regulators of the aging process, choreographing cellular health through multiple pathways that directly influence longevity – from DNA repair and inflammation control to energy metabolism optimization and mitochondrial function.

Sirtuins and Caloric Restriction

Caloric restriction (CR) or reducing your calorie intake without depriving yourself of vital nutrients¹⁸ does more than just help with weight management. It activates sirtuins, making them central to the health benefits associated with eating less.

When you practice caloric restriction, your body switches into a survival mode that activates the AMPK pathway, a key energy regulator.¹⁹ This process increases NAD+ levels, which, in turn, boosts sirtuin activity. With more active sirtuins, your body becomes better equipped to repair cellular damage, manage stress, and maintain metabolic balance.

CR has been studied for over 60 years and is the only intervention proven to increase the maximum lifespan in mammals. A study published in the Sage Journals showed that even when CR is started later in life, it still can help extend lifespan.²⁰

Research shows that caloric restriction helps extend lifespan and improve healthspan, and sirtuins help in making this happen. They mediate many of CR’s benefits, such as reducing inflammation, protecting against oxidative stress, and improving energy efficiency in cells.

How to Activate Sirtuins

Sirtuin activation doesn’t require a complete lifestyle overhaul. Small, intentional changes can get these cellular protectors working optimally. Many of these changes also improve your overall health and energy levels.

Regular exercise is one of the simplest and most powerful ways to activate sirtuins. A study published in the International Journal of Molecular Sciences found that physical activity increases NAD+ levels and triggers pathways that improve sirtuin function, especially SIRT1 and SIRT3.²¹ Even brisk walking stimulates these proteins,²² promoting better metabolism, reduced oxidative stress, and improved cellular repair.

Certain natural compounds, like resveratrol, can directly activate sirtuins.²³ Found in foods like red grapes, blueberries, and peanuts, resveratrol mimics the effects of caloric restriction by enhancing SIRT1 activity. While you’d need a lot of these foods to notice benefits, high-quality resveratrol supplements offer a more practical option.

Since sirtuins rely on NAD+ to function, boosting your NAD+ levels is also a surefire way to increase their activity. NAD+ precursors, like NMN and NR, provide the building blocks for your body to produce more NAD+. These supplements can help maintain optimal sirtuin function as you age.

For those seeking a comprehensive solution to optimize their NAD+ levels and support sirtuin activation, Vitality ↑® NAD+ Booster offers a clinically validated formulation that combines key NAD+ precursors with synergistic ingredients. This advanced supplement pairs NMN and nicotinamide with D-ribose and creatine monohydrate to enhance cellular NAD+ production and support optimal sirtuin function.

The unique combination has shown superior efficacy compared to individual NAD+ precursors alone, making it an evidence-based choice for individuals looking to support their cellular health and potentially reduce age-related decline through enhanced sirtuin activation.

SHOP NAD+ BOOSTER

The Road Ahead for Sirtuins

As our understanding of sirtuins expands, recent breakthroughs are transforming the field. Scientists have developed next-generation sirtuin activating compounds (STACs) that are up to 10 times more potent than resveratrol, with compounds like SRT1460 showing remarkable selectivity in targeting specific sirtuins.²⁴ Meanwhile, research has unveiled sirtuins’ complex role in cancer biology²⁵ and their potential as diagnostic biomarkers, with SIRT3 and SIRT7 showing particular promise in detecting systemic diseases.²⁶

While supplements and targeted interventions show increasing promise, lifestyle factors like exercise, nutrition, and stress management remain fundamental to optimal sirtuin function. The broad influence of sirtuins – spanning DNA repair, metabolism, and cellular health – makes them crucial targets for promoting healthier aging.

The story of sirtuins reminds us that aging isn’t simply a passive process but one that can be understood and influenced. Through continued research and practical applications, we’re uncovering new ways to support these cellular guardians and potentially extend our healthspan for generations to come.

Referenced Sources:

NAD Dosage Guide: Optimal Amounts and Timing

Written by Jinfiniti Science on December 16, 2024. Posted in NAD, NAD+. No Comments on NAD Dosage Guide: Optimal Amounts and Timing

Life demands your best, but fatigue, brain fog, or sluggish recovery can hold you back. Thankfully, there’s a way to recharge your body’s natural energy, repair damage at the cellular level, and even promote healthy aging.

NAD+ or nicotinamide adenine dinucleotide is a coenzyme that powers everything from repairing your cells to boosting your metabolism and even slowing signs of age-related decline through DNA repair mechanisms. It’s no surprise that NAD supplements and therapies are getting so much attention.

But how much should you take to achieve real results? Take too little, and you might not feel the difference. Too much, and you risk wasting time and money or worse, experiencing side effects.

This guide simplifies it all, helping you optimize your NAD regimen for maximum impact on overall health and longevity without the guesswork.

In this article, you’ll discover:

How factors like age, health status, and goals affect your NAD dosage and frequency.

When and how often to take NAD for maximum benefits without overdoing it.

Tips on personalizing your NAD protocol for optimal results and safety.

Common NAD Supplementation Forms

Ever wondered why there are so many different NAD supplements on the market?

While NAD+ itself is the molecule your cells need, it’s rarely supplemented directly because it has trouble reaching your cells intact – imagine trying to deliver a delicate package that falls apart before reaching its destination. Instead, we use various precursor molecules that your body can efficiently transform into NAD+.

NR (Nicotinamide Riboside): As one of the most well-studied NAD boosters, NR has earned its reputation through extensive clinical research¹. Your body efficiently processes this molecule through a well-mapped conversion pathway, making it a reliable choice for those seeking evidence-based NAD supplementation. Think of NR as having a special “fast pass” through your cellular machinery – it encounters fewer biological obstacles on its journey to becoming NAD.

NMN (Nicotinamide Mononucleotide): Available as pure NMN powder, this molecule is slightly larger than NR but still effectively raises NAD levels in your body. The cellular uptake mechanism of NMN is complex, potentially requiring conversion to NR before entering cells or utilizing a specific transporter protein.² Once inside the cell, NMN is one step closer to NAD+ in the conversion pathway.

NAM (Nicotinamide): Also known as niacinamide, this fundamental form of vitamin B3 serves as a basic building block for NAD production. Your cells are well-equipped to work with NAM, though they need to perform more conversion steps compared to other precursors.³ It’s like having raw ingredients that require more preparation steps before becoming the final dish, but the process is natural and well-understood by your body.

NAD Precursor Blends: These comprehensive formulations combine multiple NAD precursors, typically including both NMN and NR, to potentially optimize NAD production through various pathways. Think of it as taking multiple routes to the same destination – while one precursor might be more effective in certain tissues, another could work better elsewhere, potentially providing more complete coverage for your NAD-boosting goals.

Vitality ↑® NAD+ Booster is a precursor blend that combines NMN and nicotinamide with Creatine monohydrate and D-Ribose, designed to support both NAD production and cellular energy metabolism in one comprehensive formula.

NAD Therapy Methods

There are also alternative methods to administer NAD that have become increasingly popular in wellness clinics and medical practices, though it’s important to note that research has not yet definitively proven these methods increase intracellular NAD levels:

NAD Injections: For those seeking a more direct approach, NAD shots offer a way to bypass the digestive system entirely. These intramuscular injections deliver NAD precursors directly into your muscle tissue, where they can be gradually released into your bloodstream. Think of it like having a time-release capsule planted directly in your muscle – while it might sound intense, many people choose this option for its convenience and potentially faster absorption compared to oral supplements.

NAD IV Therapy: Taking it a step further, NAD IV therapy delivers NAD precursors directly into your bloodstream through an intravenous drip. While this method requires you to remain stationary for several hours during treatment, proponents appreciate its immediate availability. This approach is particularly popular among those seeking intensive NAD support for chronic issues, though it requires a bigger time commitment and typically comes with a higher price tag than other methods.

The Optimal Dosage for NAD Supplements

Finding the ideal dosage for NAD+ supplements can feel a bit like solving a puzzle – while research provides some general guidelines, individual needs can vary significantly. Let’s explore what science tells us, and then discuss how to find your personal sweet spot.

Clinical studies have examined various doses across different NAD precursors:

NR (Nicotinamide Riboside): Research typically uses doses ranging from 100mg to 1000mg daily, with most studies centering around 250mg to 500mg per day.⁴ These amounts have been shown to effectively increase NAD levels while maintaining a strong safety profile.

NMN (Nicotinamide Mononucleotide): A systematic review of randomized controlled trials on NMN supplementation found that dosages ranged from 150 to 1200 mg per day.⁵ Studies using 250-900 mg/day of NMN supplementation showed significant improvements in blood NAD concentration.⁶

NAM (Nicotinamide): NAM is well-tolerated at doses up to 3 g per day, even during long-term administration.⁷ A single oral dose of NAM within the daily tolerable upper level (900 mg for adults) significantly increased blood NAD+ levels in healthy subjects.⁸

However, here’s the important part – while these studies provide valuable reference points, determining your optimal dose isn’t as simple as picking a number from a study. Your ideal dosage depends on various factors including your current NAD levels, age, lifestyle, and specific health goals.

That’s why we recommend getting an intracellular NAD test to establish your baseline and monitor your response to supplementation. This personalized approach helps ensure you’re not over or under-supplementing, but rather hitting that sweet spot for your unique biological needs.

NAD Dosage for Injection and IV Therapy

Just like with oral supplements, dosing for injectable NAD therapies requires careful consideration, though clinical evidence for optimal doses is more limited. Here’s what we currently know about typical protocols:

NAD Injection Doses: Most clinics administer NAD shots in doses ranging from 50mg to 200mg per injection. Treatment protocols might involve a series of injections spaced over days or weeks, similar to how you might space out B12 shots. However, it’s important to note that individual clinics may use different protocols, and the optimal injection schedule isn’t yet established by rigorous clinical research.

NAD IV Therapy Doses: IV protocols typically use higher doses, ranging from 500mg to 1500mg per session, delivered over several hours. Think of it as a slow, steady infusion rather than a quick shot – the gradual administration helps minimize potential side effects like flushing or nausea. Treatment programs often start with a series of consecutive daily sessions (typically 3-10 days) followed by maintenance sessions scheduled weeks or months apart.

Remember that while these treatments are widely offered at wellness clinics, we’re still awaiting more comprehensive research to fully understand their impact on intracellular NAD levels and long-term benefits.

When and How Often to Take NAD

Timing your NAD supplementation might not be as important as getting the right dose, but a few practical guidelines can help optimize your routine:

Daily consistency: NAD precursors work best when taken consistently every day. It’s similar to keeping a car’s gas tank from running too low – regular intake helps maintain stable NAD levels in your cells.

Morning vs evening: Most people prefer taking NAD boosters in the morning since they can promote energy production. If you experience any energizing effects, an early dose helps prevent sleep disruption. If you don’t notice any stimulating effects, you can take it any time that fits your schedule.

With or without food: While most NAD precursors can be taken with or without food, some people report better tolerance when taken with meals. If you notice any stomach sensitivity, pairing your supplement with breakfast can help smooth the process.

The goal is to find a routine that you can stick to consistently – whether that’s with your morning coffee or as part of your breakfast ritual. The best timing is ultimately the one that works reliably with your daily schedule.

Factors to Consider When Choosing a Dose

Selecting the right NAD dose isn’t a one-size-fits-all proposition. Your optimal dosage depends on several personal factors that influence how your body produces and uses NAD:

Age: NAD levels by age group show a clear pattern – they naturally decline as we get older. While a younger person might maintain healthy NAD levels with a modest supplement dose, someone in their 60s or 70s may need higher amounts to achieve similar benefits.⁹ It’s like how our calcium needs increase with age to maintain bone strength.

Health status: Your current health situation should be considered in determining dosage needs. Certain health conditions may increase NAD consumption in your cells, requiring higher supplementation levels. Medical conditions that affect metabolism or energy production are particularly relevant when determining your optimal dose.

Baseline NAD+ levels: Starting NAD levels vary significantly between individuals. A baseline test can reveal whether you’re starting from a deficit or maintaining relatively healthy levels, helping guide your supplementation strategy.

Genetic factors: Your genetic makeup influences how efficiently your body processes NAD precursors. Some people naturally convert these compounds more effectively than others, affecting their optimal dosage requirements.

Diet and lifestyle: Those exploring NAD for weight loss or active lifestyles might have different requirements. Regular exercise, stress levels, and dietary patterns all influence NAD metabolism. For instance, high-intensity workouts may increase your body’s NAD demands, while certain dietary choices can support or hinder NAD production.

Given these variables, it’s particularly important for older individuals or those with specific health conditions to work with healthcare providers in determining their optimal dose. They can help monitor your response and adjust dosage based on your individual needs and goals.

Remember: Higher doses aren’t always better. The goal is to find the sweet spot that optimizes your cellular health while considering your unique biological context.

Safety and Precautions

While NAD precursors generally have a strong safety profile when taken orally, it’s important to understand potential risks and take appropriate precautions:

Oral supplement side effects: Most people tolerate oral NAD precursors well, with mild effects like occasional flushing or slight stomach discomfort being the most common reactions. Starting with a lower dose and gradually increasing it can help minimize these effects. Many find these mild symptoms diminish after the first few days of supplementation.

Injectable treatments: NAD therapies like IV drip sessions carry additional considerations. The direct delivery into your bloodstream can cause more immediate and noticeable side effects such as chest tightness, flushing, headache, or nausea. These treatments should only be administered by qualified healthcare professionals who can monitor your response and adjust infusion rates accordingly.

Drug interactions: NAD precursors may interact with certain medications, particularly those affecting cellular metabolism or blood pressure. Your healthcare professional should review your current medications before starting any NAD supplementation regimen.

Pre-existing conditions: People with certain health conditions, particularly those affecting liver or kidney function, should exercise extra caution and seek medical guidance before starting NAD supplementation. These organs play crucial roles in processing supplements, so their health status matters significantly.

Pregnancy and nursing: Due to limited research in these populations, pregnant or nursing individuals should consult their healthcare providers before starting any NAD supplementation.

Personalizing Your NAD Protocol

Finding your optimal NAD protocol is a journey that benefits greatly from a data-driven, personalized approach. Rather than guessing or following one-size-fits-all recommendations, you can make informed decisions about your NAD optimization:

Start with testing: The Intracellular NAD® Test provides clarity in your NAD optimization journey. Unlike blood tests that only show circulating levels, this innovative test measures NAD where it matters most – inside your cells. By establishing your baseline and monitoring changes, you can verify if your supplementation strategy is truly effective.

Choose clinically-validated support: The Vitality ↑® NAD+ Booster takes NAD supplementation to the next level. This advanced formulation strategically combines NAD precursors (NMN and nicotinamide) with cellular energy enhancers (Creatine monohydrate and D-Ribose). This synergistic blend supports NAD production while optimizing your cells’ energy metabolism pathways.

Remember, successful NAD optimization isn’t just about taking supplements – it’s about understanding your body’s unique needs and response to treatment. Combining precise testing with targeted supplementation will help you develop a truly personalized protocol that delivers measurable results for your cellular health and vitality.

References:

Woman drinking a glass of water with her morning NMN supplement

11 Promising Benefits of NMN Supplements

Written by Jinfiniti Science on December 14, 2024. Posted in NAD+, NAD+ Precursors, NMN. No Comments on 11 Promising Benefits of NMN Supplements

Nicotinamide mononucleotide or NMN for short is a precursor to nicotinamide adenine dinucleotide (or NAD+), the coenzyme that bridges communication between cellular systems, translating biochemical signals and maintaining coordination across our body’s complex physiological networks.

NMN supplementation works to replenish NAD+ levels through multiple biosynthetic pathways. It can be synthesized from nicotinamide, converted via specific kinases, and integrated directly into NAD+ production, offering a multi-pronged approach to cellular health optimization.

Longevity researchers have increasingly focused their lens on NMN’s benefits, as studies suggest supplementation may support cardiovascular function, metabolic health, cognitive performance, and DNA repair mechanisms that typically decline with age.

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In this article, we’ll explore:

11 clinically-backed benefits of NMN supplementation for health and longevity
How long it takes to experience the effects of NMN supplementation
Evidence-based dosage recommendations for optimal results

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Benefits of NMN

NMN supplement capsules falling out of bottle

A mounting body of research shows that supplementing with NMN orally can raise NAD+ levels in the human body which leads to wide ranging benefits. Here are 11 research-backed benefits of taking NMN, from stronger heart function to greater muscular endurance.

Cardiovascular Health

Research published in Aging Cell points to NMN’s potential for improving cardiovascular health and combating age-related vascular problems. When older mice received NMN supplements, their arterial function showed remarkable improvements – blood vessels dilated more effectively and arteries became less stiff. The study found that NMN works by reducing oxidative stress while boosting protective molecules like elastin in the blood vessels. What’s more, it helped restore SIRT1 activity, an important enzyme for vascular health, while decreasing harmful oxidative byproducts in the arteries¹.

NMN has also shown protective effects against the progression of atherosclerosis. A clinical study in the Journal of Functional Foods showed NMN supplementation effectively reduced the formation of atherosclerotic plaques in mice on a high-fat diet².

Fertility

Research published in Cell Press found that NMN supplementation improved egg quality and increased live birth rates in aging female mice by supporting mitochondrial function³. The study demonstrated that NMN helped counteract age-related decline in egg quality, particularly in older females. While these findings point to NMN’s potential role in maintaining female fertility during aging, research is still needed to confirm similar effects in humans.

Skin Health

A study published in Glycative Stress Research showed that oral NMN supplementation significantly improved multiple aspects of skin health over 8 weeks, including moisture, firmness, and roughness⁴. The study documented meaningful reductions in skin autofluorescence values, indicating lower levels of advanced glycation end products (AGEs) in participants’ skin. Subjects experienced visible improvements in their skin’s appearance, with measurable changes in age spots, wrinkles, and freckles.

Cognitive Health

Research in Redox Biology showed that NMN supplementation for two weeks restored neurovascular coupling responses in aged mice to youthful levels while improving their spatial memory and movement coordination⁵. The cognitive improvements stemmed from reduced oxidative stress and better blood vessel function in the brain, with the study pointing to NMN’s role in restoring NAD+ levels and mitochondrial function.

Digestive System Health

A recent study in the Journal of Translational Medicine revealed that NMN supplementation led to significant improvements in digestive health, with participants reporting less abdominal pain, bloating, and constipation⁶. The research showed NMN increased beneficial gut bacteria populations, particularly Bifidobacterium and Faecalibacterium, while strengthening the intestinal barrier and lowering inflammation markers. These findings demonstrate NMN’s valuable role in promoting gut microbiome health and alleviating digestive discomfort.

Metabolic Health

A 2011 pilot study at Washington University School of Medicine explored NMN as both a biomarker and potential treatment for age-related metabolic disorders⁷. Mouse studies revealed that aging and high-fat diets impaired NAMPT-mediated NAD biosynthesis, leading to type 2 diabetes development. NMN treatment improved insulin sensitivity and function while restoring genes linked to oxidative stress, inflammation, and circadian rhythm in diabetic mouse livers through SIRT1 activation.

DNA Repair

A review article by Rahman et al. published in Aging and Disease discusses how NMN supplementation reduces DNA damage and cellular aging in both mouse models and human cells⁸. The compound works by raising NAD+ levels and activating PARP1, which helps repair damaged DNA strands. These findings point to NMN as a potential treatment for preventing and reversing age-related DNA deterioration.

Eye Function

A 2023 review in Graefe’s Archive for Clinical and Experimental Ophthalmology examined NMN’s role in treating eye diseases, drawing from recent literature and original research. Studies in mice demonstrated that NMN helped regulate inflammation, oxidative stress, and metabolism in conditions like glaucoma, retinopathy, and macular degeneration⁹. Findings point to NMN as a promising treatment for various eye disorders, but researchers note that more preclinical studies are needed to validate these results.

Energy Levels

Research shows NMN supplementation helps restore NAD+ levels¹⁰, which supports healthy energy metabolism and mitochondrial function. This increased NAD+ availability allows for better cellular energy production and improved metabolic efficiency¹¹. NMN supplementation may also optimize sirtuin proteins’ ability to regulate energy at the cellular level through its effects on NAD+.

Anti-Aging

A review in the Journal of Advanced Research by Harshani et al. explores NMN’s potential as an anti-aging compound¹². Animal studies suggest NMN supplements can improve conditions like diabetes, cardiovascular disease, and neurodegenerative disorders through their effects on mitochondrial function, oxidative stress levels, and DNA repair mechanisms. These cellular improvements may help slow the aging process, though research is ongoing to confirm findings in humans.

Muscle Endurance

In a six-week randomized, double-blind, placebo-controlled trial published in the Journal of the International Society of Sports Nutrition, researchers found that NMN supplementation improved ventilatory threshold and aerobic capacity in amateur runners¹³. The improvements were dose-dependent and centered on skeletal muscle efficiency rather than cardiac function, with NMN increasing oxygen utilization in muscle tissue. These findings point to NMR supplementation combined with training as a promising approach for improving athletic endurance.

How Long Do the Effects of NMN Take to Work?

The timeline for experiencing NMN’s benefits varies depending on the specific health aspects you’re targeting and your individual biology. Research and user experiences suggest different timeframes for various effects:

Immediate Energy Effects (Hours to Days): Some users report feeling increased energy and mental clarity within the first few days of supplementation, as NMN begins supporting cellular NAD+ production.
Short-Term Benefits (2-4 Weeks): Improvements in physical performance, exercise capacity, and energy metabolism typically become noticeable within the first month of consistent supplementation.
Mid-Term Changes (1-3 Months): Skin health improvements, better sleep quality, and cognitive function benefits often become apparent during this period, as demonstrated in several clinical studies.
Long-Term Benefits (3-6 Months+): More fundamental improvements in cardiovascular health, metabolic function, and age-related markers typically require several months of consistent supplementation to become noticeable.
Preventive Benefits (Ongoing): Some of NMN’s most important effects, such as DNA repair and longevity support, work continuously in the background and may not have immediately noticeable effects but contribute to long-term health maintenance.

NMN Supplement Dosage Ranges

Research has shown that NMN supplementation can be effective across various dosage ranges, with studies demonstrating benefits from as low as 250 mg up to 1200 mg daily. The right dosage depends on individual factors and specific health goals, though most research centers on a few key ranges.

Starter Dose (250-300 mg/day): Ideal for beginners and shown effective in clinical studies for raising NAD+ levels, particularly in healthy adults looking for general wellness support.
Standard Dose (500-600 mg/day): The most commonly studied range, demonstrating optimal results for physical performance and NAD+ concentration in blood, with strong safety data behind it.
Advanced Dose (900-1200 mg/day): Higher doses studied in specific research settings, showing good tolerability for up to 8 weeks, typically reserved for specific therapeutic purposes or older adults.
Maintenance Dose (250-500 mg/day): Often recommended for long-term daily supplementation after achieving desired results with higher doses.

Your optimal NMN dosage should consider factors like age (older adults may benefit from higher doses), body weight, overall health status, and specific wellness goals. Most experts recommend starting at a lower dose (250 mg) and gradually increasing if needed while monitoring your body’s response. For sustainable results, consistency in supplementation is often more important than taking maximum doses.

Jinfiniti’s Pure NMN supplement comes in a convenient powder form, making it easy to control and adjust your daily dosage.

NMN Benefits: Key Takeaways and Future Prospects

The research surrounding NMN supplementation continues to paint a compelling picture of its potential impact on human health and longevity. From supporting cardiovascular function and cognitive performance to improving cellular energy production and DNA repair mechanisms, NMN’s wide-ranging benefits stem from its fundamental ability to boost NAD+ levels throughout the body.

Looking ahead, the field of NMN research shows tremendous promise. Ongoing clinical trials are exploring new therapeutic applications, from age-related disease prevention to potential treatments for specific health conditions. As our understanding of NAD+ metabolism deepens, researchers continue to uncover new mechanisms through which NMN supplements might support healthy aging and cellular function.

While single-ingredient NMN supplements are common, research shows that NAD+ production relies on multiple cellular pathways. Our Vitality ↑® NAD+ Booster leverages this scientific understanding by combining proven NAD+ precursors NMN and nicotinamide with D-Ribose and Creatine to support cellular energy production. Our supplements are produced at a GMP-certified manufacturing facility, ensuring quality, safety and consistency.

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Referenced Sources

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Longevity Gift Guide 2024: Must-Haves for Healthy Aging

Written by Jinfiniti Science on December 11, 2024. Posted in At-Home Testing, Longevity, Supplements. No Comments on Longevity Gift Guide 2024: Must-Haves for Healthy Aging

In a season of giving, what better gift could there be than a blueprint for healthy aging?

Welcome to our 2024 Longevity Gift Guide, where we’ve wrapped up Jinfiniti’s most innovative offerings in one festive package. Whether you’re shopping for a seasoned biohacker or someone just beginning their wellness journey, we’ve curated the perfect selection of science-backed solutions to support healthy aging.

From our first-of-its-kind NAD test that unlocks insights into cellular health, to in-depth biomarker panels that paint a complete picture of wellbeing, to biological age tests that reveal your true physiological age – each product in our guide has been carefully selected to make a meaningful impact. Paired with our targeted supplements and thoughtfully crafted bundles, these gifts go beyond the ordinary, offering your loved ones the tools they need to take control of their healthspan.

Our Top 3 Gift Ideas

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AgingSOS® Biomarker Panels

Give your health-conscious loved ones the ultimate gift of knowledge with our AgingSOS® Biomarker Panels – sophisticated tests that reveal exactly what’s happening in their cells and give them a clear roadmap for living longer, healthier lives.

AgingSOS® Starter Panel

Give the gift of precision longevity with our AgingSOS® Starter Panel, your gateway to understanding aging at the cellular level. This comprehensive screening measures 16 essential biomarkers across six vital categories, from NAD levels to cellular senescence, providing a detailed map of your aging journey. Each test includes actionable recommendations and a free consultation, all while maintaining complete data privacy. This holiday season, wrap up the gift of knowledge – a personal roadmap to optimizing healthspan through science-backed insights.

AgingSOS® Advanced

For those serious about optimizing their longevity journey, the AgingSOS® Advanced Panel offers unparalleled insights through 22 comprehensive biomarkers. This premium gift delves deeper into critical aging factors, including mitochondrial function, DNA damage, and longevity hormones – many of which are exclusive to this panel. Perfect for identifying root causes and hidden health factors, each test includes actionable recommendations and a complimentary consultation.

AgingSOS® Senescence & NAD Panel

Unwrap the secrets of cellular aging with our Senescence & NAD Panel, the perfect gift for tracking anti-aging protocol effectiveness. This specialized test measures intracellular NAD and key senescence markers, including β-galactosidase and four inflammatory proteins. Whether evaluating senolytics or monitoring cellular health, this panel provides clear insights into your body’s aging process. Complete with private data protection and expert consultation, it’s the ideal gift for those optimizing their longevity strategies.

Biological Age Test

Want to know if your healthy lifestyle is actually slowing down aging? A biological age test goes beyond counting birthdays to show you how well your body is really aging at a deeper level.

AgeRate Epigenetic Age

Discover the truth about biological aging with our AgeRate Epigenetic Age test. Using DNA methylation analysis across 10,000+ sites, this advanced test reveals your true biological age – a far more meaningful marker than calendar years. Powered by AI and backed by extensive population data, it’s the gold standard for measuring how well you’re aging. Give the gift of epigenetic insight and empower your loved ones to validate their longevity efforts with precision science.

NAD Testing Kit

Tired of guessing whether your NAD supplements are actually working? Our test kit takes the mystery out of your supplement routine by measuring your actual levels inside your cells.

Intracellular NAD® Test

Transform your NAD optimization journey with our clinically-validated Intracellular NAD® Test, the definitive way to verify if your NAD supplements or treatments are truly working. Perfect for health optimizers, athletes, and anyone over 30 seeking to maintain peak cellular energy. This simple at-home test requires just a few drops of blood and delivers comprehensive results within days.

Longevity Supplements

Looking for the perfect stocking stuffer for your health-obsessed friends and family? Our research-backed longevity supplements pack powerful cellular benefits into gift-sized packages.

Vitality ↑® NAD+ Booster

Our breakthrough Vitality ↑® NAD+ Booster represents a new era in cellular optimization. This patent-pending formulation combines NAD precursors NMN and nicotinamide with Creatine monohydrate and D-Ribose to boost NAD levels more effectively than traditional supplements. From enhanced energy and mental clarity to improved sleep and reduced inflammation, it’s the perfect choice for anyone seeking comprehensive cellular rejuvenation. Give the gift of verified vitality with our scientifically validated formula.

Extra Strength Turmeric+

Our premium Extra Strength Turmeric+ combines ancient wisdom with modern science, delivering 950mg of high-purity curcuminoids in each serving. This powerful formula synergizes turmeric extract with Boswellia, ginger root, quercetin, and piperine for maximum absorption and effectiveness. Thoughtfully designed to support natural inflammation response and joint health, while providing powerful antioxidant benefits.

SenoAid™ – Senolytic Supplement Complex

Meet SenoAid™, our advanced senolytic supplement complex designed to support your body’s natural cellular renewal processes. This precision-crafted formula combines quercetin dihydrate and fisetin with bromelain and green tea extract, working synergistically to address cellular senescence – a key factor in biological aging. Enhanced with piperine for optimal absorption.

Creatine+ATP

Our advanced Creatine+ATP formula harnesses the synergistic power of pure creatine monohydrate and disodium ATP to optimize cellular energy production. This dynamic duo not only enhances muscle strength and recovery but also supports cognitive function through improved neurotransmitter activity. Perfect for those seeking to boost their body’s energy currency while supporting muscle mass – a key factor in longevity.

Pure NMN

Our high-purity NMN powder supplement, featuring >99.5% pure nicotinamide mononucleotide for efficient cellular NAD+ conversion. This streamlined formula offers a cost-effective path to NAD optimization, available in both 30g and 120g sizes. Supporting energy production, sleep quality, and reduced inflammation, it’s an excellent choice for those beginning their NAD+ journey. Simple, pure, and effective – cellular optimization made accessible.

Longevity Gift Bundles

Give friends and family everything they need to start and sustain their longevity journey with our money-saving bundles – carefully curated packages that pair our most popular supplements with the testing needed to verify and track results.

NAD Optimization® Starter

Begin your NAD journey with confidence using our proven optimization package. This strategic bundle includes two Intracellular NAD® tests to track your progress, one Vitality ↑® NAD+ Booster supplement, plus a bonus supplement and expert consultation. Perfect for establishing your baseline NAD levels, determining optimal dosage, and measuring real results after four weeks. Take the guesswork out of NAD optimization with a scientifically-validated approach to cellular health.

NAD Maintenance Package

Sustain your optimal NAD levels with our comprehensive maintenance bundle. This value package includes six jars of our Vitality ↑® NAD+ Booster at a reduced price, plus a half-price Intracellular NAD® test to verify your continued success. Complete with free expert consultation, it’s the smart choice for those committed to long-term cellular optimization. Because maintaining peak NAD levels isn’t just about starting strong—it’s about staying strong.

NAD Optimization® Mini Starter

Dip your toes into NAD optimization with our streamlined mini starter package. This entry-level bundle combines one Intracellular NAD® test and one Vitality ↑® NAD+ Booster at 50% off, giving you everything needed to begin your cellular health journey. Establish your baseline NAD levels and start experiencing benefits, with the flexibility to add additional testing or upgrade to our full starter package later. The perfect introduction to scientific NAD optimization.

Wrap Up Healthy Aging This Year

This holiday season, give the gifts that truly keep on giving – the tools and insights for a longer, healthier life. Whether you choose our groundbreaking NAD tests to optimize cellular energy, comprehensive AgingSOS® panels to map out a personalized longevity strategy, or our scientifically-validated supplements to support cellular health, you’re not just giving a present – you’re giving the promise of a more vibrant future.

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What are NAD Shots and Do They Really Work?

Written by Jinfiniti Science on December 9, 2024. Posted in NAD, NAD+. No Comments on What are NAD Shots and Do They Really Work?

NAD shots have emerged as the latest trend in the wellness and longevity space, with celebrities and health influencers turning to these injections in hopes of boosting energy, slowing aging, and improving cognitive function. The treatment, which delivers nicotinamide adenine dinucleotide (NAD+) directly into the bloodstream, has sparked both excitement and skepticism in the medical community, raising questions about its effectiveness and scientific backing.

As interest in NAD+ therapy continues to grow, many are wondering whether these expensive treatments live up to their promise.

In this article, you’ll discover:

What NAD shots are and how they work, including the key differences between intramuscular and subcutaneous injection methods

The potential benefits and limitations of NAD injection therapy, from energy levels and cognitive function to its cellular absorption challenges

How NAD shots compare to alternative methods like IV therapy and oral supplements, including costs, convenience, and effectiveness for boosting cellular NAD+ levels

What is a NAD Shot?

NAD shots are intramuscular injections that administer the essential coenzyme NAD+ directly into the bloodstream. The injectable form of NAD+ aims to bypass digestive absorption limitations of oral supplements, theoretically providing higher bioavailability. Medical professionals typically administer these shots in clinics or wellness centers as part of anti-aging or regenerative medicine protocols.

NAD injections rose to prominence through their initial use in addiction treatment centers in the early 2010s, followed by growing adoption in anti-aging medicine between 2015-2020. Research linking NAD+ decline to aging, combined with celebrity endorsements and social media coverage, helped mainstream these treatments.

The health and wellness industry’s marketing of NAD therapy as a cellular rejuvenation treatment, particularly through upscale clinics and medical spas, cemented its position as a premium intervention, despite limited clinical evidence for many claimed benefits.

The Process of NAD Injection Therapy

NAD+ injection therapy is administered via intramuscular or subcutaneous shots, offering a quicker alternative to NAD IV therapy. The process takes just minutes: a healthcare provider cleans the injection site (typically the arm, thigh, or gluteal area) and administers the NAD+ solution. Most protocols involve a series of injections over several days or weeks, with doses typically ranging from 100-200mg per shot.

Side effects are generally milder than IV therapy since the NAD+ is absorbed more gradually through muscle tissue. Patients may experience temporary soreness at the injection site.

Two Forms of NAD Injection

NAD injections come in two main forms: intramuscular (IM) and subcutaneous (SubQ). Both deliver NAD+ directly into your body, but the method you choose can affect how quickly and steadily the benefits kick in.

IM injections go deep into a muscle, like your thigh, hip, or upper arm. Because muscles have a rich blood supply, this method allows NAD+ to absorb quickly into your system. People often choose this route for a rapid energy boost or sharper focus. The process itself is simple and fast, often taking just a few minutes.

SubQ injections introduce NAD+ into the layer of fat just beneath your skin, creating a different pharmacokinetic profile. This tissue acts as a natural time-release system, gradually dispensing NAD+ into your circulation. It’s also a gentler method, with less discomfort than IM injections.

Regardless of the method chosen, professional medical supervision ensures proper administration, optimal dosing, and safe implementation of NAD+ therapy as part of your cellular health strategy.

Potential Benefits of NAD Shots

NAD shots are becoming popular for their potential to boost energy, sharpen mental clarity, and support healthy aging. However, the majority of studies show that the health benefits of NAD+ come from boosting NAD+ through supplementation rather than injection therapy specifically.

That said, if you’re dealing with symptoms of low NAD levels, such as fatigue, brain fog, or slower recovery, these shots might help replenish your NAD+ reserves. However, you should view them as one of many tools to reap the benefits of NAD+ listed below.

May Improve Energy Levels and Athletic Recovery

When you increase your NAD+ levels, you boost mitochondrial function, leading to more efficient energy production. A study published in Cell Metabolism found that boosting NAD levels improved muscle function and the creation of new mitochondria.¹ Increasing your NAD+ levels can give your cells the energy boost they need to combat fatigue and recover more effectively after physical exertion.

May Boost Mental Clarity and Improve Cognitive Function

NAD+ also supports brain health by improving the health and function of mitochondria. It also reduces inflammation in brain cells, which can impair cognitive performance. A study published in the Journal of Neuroinflammation revealed that NAD+ supplementation helped protect mitochondria and reduce cellular stress,² supporting your brain’s ability to repair itself and function more efficiently.

May Support Healthy Aging

Boosting NAD+ activates sirtuins,³ which are proteins that help protect against age-related diseases and promote longevity. By keeping NAD+ levels optimized, you may see improvements in skin elasticity, muscle strength, and overall vitality. Check healthy NAD+ levels for your age group to understand where you stand and take proactive steps to maintain your health as you age.

May Help With Mood Regulation and Stress

NAD+ boosts mitochondrial function and supports brain cell health, which can help you handle stress and keep your mood more stable. A study in Cell Metabolism found that NAD+ helps regulate neurotransmitters like serotonin,⁴ which directly impact your mood and emotional well-being. This makes it easier to stay calm and focused, even when things get tough.

Do NAD+ Injections Really Work?

While NAD+ injections may temporarily boost your NAD+ levels, the impact might be more limited than you expect. For instance, intramuscular injections introduce NAD+ into the bloodstream, but the large size of the NAD+ molecule presents a significant challenge – like trying to push a basketball through a tennis net, intact NAD+ molecules struggle to cross cell membranes efficiently.⁵ This limitation applies to both intravenous and intramuscular routes of administration.

There’s also evidence suggesting that direct exogenous NAD+ administration (via oral, IV, or intramuscular routes) is metabolically inefficient.⁶ The molecule needs to be broken down into its constituent parts before cellular entry, which may limit its direct effects.

Most studies demonstrating an ability to increase NAD+ levels⁷ rely on oral precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). These compounds are converted into NAD+ within cells,⁸ allowing for sustained increases in NAD+ levels. They are more readily absorbed and used by cells to produce NAD+ internally.

Key Takeaway: While NAD+ injections can boost blood levels quickly, precursor molecules like NMN and NR may be more effective at increasing NAD+ where it matters most – inside your cells.

Are There Any Side Effects of NAD+ Injections?

Most side effects of NAD+ injections are mild and temporary:

Injection Site Reactions: Brief soreness, redness, or swelling where the injection was given
Systemic Responses: Temporary flushing, mild headaches, or lightheadedness as your body adjusts to increased NAD+ levels
Cardiovascular Effects: Some people experience a brief increase in heart rate during administration

Certain conditions require careful medical evaluation before starting NAD+ therapy:

Heart conditions that could be affected by changes in cardiovascular function
Kidney or liver disorders that might alter NAD+ metabolism
Pregnancy or breastfeeding
Active chemotherapy treatment or medications that interact with NAD+ pathways
History of allergic reactions to injectable medications

How Often Can You Get NAD+ Injections?

The frequency of NAD+ injections depends on your goals and health needs. For an initial boost, you might start with 2-3 injections per week over a few weeks. Once your NAD+ levels are up, you can switch to a maintenance routine, usually one injection every 1-2 weeks.

For long-term support, you can opt for a monthly session to keep NAD+ levels steady. Your schedule can be adjusted based on how your body reacts, so it’s good to keep an eye on any changes or side effects as mentioned above. It’s always best to work with a healthcare provider to find the right balance for you.

Are NAD Injections Better Than NAD IV Therapy?

When comparing NAD injections to NAD IV therapy, both methods aim to boost NAD+ levels, but there are some key differences. NAD injections, whether intramuscular or subcutaneous, deliver NAD+ into the bloodstream more directly.

IV therapy also bypasses the digestive system entirely for faster absorption. However, like injections, it doesn’t guarantee a rise in cellular NAD+ without the addition of supplements or NAD precursor compounds.

In terms of price, NAD injections are much more affordable. They usually cost between $30-$60 per session, whereas NAD IV therapy can range from $150 to $500 per session. So, if cost is a factor, injections are the cheaper option, though IV therapy might be a better choice for those wanting a higher dose in a single treatment.

Injections are also much quicker, taking only about 10-15 minutes. NAD IV therapy can take anywhere from 1-2 hours. If you’re short on time, injections might be a better fit for your schedule.

Injections are also more convenient. They can often be done in a clinic or even at home, depending on the type. NAD IV therapy usually requires a visit to a medical facility, making it less ideal if you have limited time or mobility.

Both injections and IV therapy can raise NAD+ levels in the bloodstream, but neither has been proven to boost intracellular NAD+ without extra supplementation. While some people feel more energized or mentally clear after treatments, studies have not shown that either method dramatically improves energy, mental clarity, or overall health long-term.

In the end, the choice comes down to personal preferences and goals. If you’re after a quick, affordable option, NAD injections may be the way to go. But if you’re looking for a more intensive dose and don’t mind the time commitment, NAD IV therapy could work for you.

NAD Supplementation May Be a Better Option

NAD+ precursors like NMN and NR are compounds your body can convert into NAD+⁹. These precursors are available in supplement form and are often considered a more effective option for boosting NAD+ levels.

One of the main advantages of NAD+ supplements is their convenience and affordability compared to injections or IV therapy. You can take these supplements daily, and they are safe and well-tolerated¹⁰.

The sustained approach of daily supplementation offers distinct advantages. Rather than experiencing dramatic spikes in NAD+ levels followed by drops, precursor supplements maintain steady cellular NAD+ levels over time.¹¹ This consistency supports ongoing cellular energy production and DNA repair processes, potentially offering more stable long-term benefits.

NAD+ precursors are also efficiently absorbed and converted by cells.¹² These supplements can raise intracellular NAD+ levels, which is more effective than the extracellular NAD delivered by injection or IV. As such, NAD supplementation is more effective than IV therapy and injections for much the same reasons.

For optimal results, research suggests that combining different NAD+ precursors can enhance overall effectiveness. Our Vitality ↑® NAD+ Booster takes advantage of this synergistic approach, combining precise doses of NMN and nicotinamide (NAM) with complementary compounds D-ribose and creatine. This all-in-one formula targets multiple pathways of NAD+ production while supporting cellular energy systems, offering a convenient solution for those seeking to optimize their NAD+ levels naturally.

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Before Choosing, Test Your NAD Levels

Making informed decisions about NAD+ optimization starts with understanding your current cellular NAD+ levels. Like any biomarker that influences cellular health, baseline NAD+ testing provides crucial data to guide your therapeutic approach and monitor treatment effectiveness.

Intracellular NAD+ testing reveals more than just numbers – it offers insights into your cellular health and helps determine which intervention might work best for your specific situation. Whether you’re considering injections, IV therapy, or oral supplementation, knowing your baseline levels allows you to track progress and adjust your protocol for optimal results.

Experience this scientific approach to NAD+ optimization with our AgingSOS® longevity panel, which precisely measures intracellular NAD+ levels alongside other key markers of cellular health. This comprehensive assessment helps create a targeted strategy for supporting your cellular energy systems and monitoring your progress over time.

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What is NMN (Nicotinamide Mononucleotide)?

Written by Jinfiniti Science on December 7, 2024. Posted in NAD+, NMN. No Comments on What is NMN (Nicotinamide Mononucleotide)?

Scientists studying the biology of aging have increasingly placed NMN supplementation at the center of their research, as evidence mounts for its wide-ranging effects on cellular health, metabolism, and cognitive performance.

As a direct precursor to NAD+, NMN (short for nicotinamide mononucleotide) helps your body produce the essential coenzyme that powers hundreds of biological processes in every cell.

While NAD+ (short for nicotinamide adenine dinucleotide) occurs naturally in your body, its levels decline substantially with age. This reduction correlates with many hallmarks of aging, from decreased energy levels to reduced cellular repair capacity.

Current research suggests NMN supplementation may support:

Cellular energy production
Metabolic health
Cardiovascular function
Brain performance
Physical endurance
Recovery and repair
Healthy aging mechanisms

Leading longevity researchers, most famously Harvard’s David Sinclair, are now investigating how NMN supplementation might help maintain cellular function as we age. This definitive guide cuts through the noise to examine what current science tells us about NMN’s benefits, optimal usage, safety profile, and potential role in healthy aging.

In this article, you will discover:

What NMN is and how it helps your body produce NAD+, a vital molecule that powers cellular health and declines with age
The research-backed benefits of NMN for healthy aging, including improvements in energy production, metabolism, cardiovascular health, and brain function
Essential guidelines for NMN supplementation, including optimal dosage, timing, safety profile, and how to select a high-quality supplement

What is NMN?

NMN is a sophisticated molecular compound classified as a nucleotide. It consists of three key components: nicotinamide (a form of vitamin B3), a ribose sugar, and a phosphate group. While this might sound technical, understanding NMN’s structure helps explain why it’s so effective: it’s essentially NAD+ minus the final piece needed for completion. This makes it a highly efficient precursor – think of it as a nearly-finished product that your body can quickly convert into NAD+.

But what makes NMN particularly special among NAD+ precursors? Unlike some other compounds, NMN is remarkably similar to naturally occurring cellular molecules. Your body produces small amounts of NMN through various pathways, primarily using nicotinamide (NAM) or nicotinamide riboside (NR) as starting materials. You also get tiny amounts when consuming certain plant and animal foods¹ – though these dietary sources provide far less than what’s needed to significantly impact NAD+ levels, especially as we age.

The journey from NMN to NAD+ is more intricate than initially thought. When you take NMN orally, it undergoes several transformations before reaching your cells. Current research indicates that NMN is first broken down into simpler forms – primarily NAM and NR. This breakdown is actually necessary because NMN’s phosphate group makes it too large to easily cross cell membranes on its own.

There are two main routes for cellular entry: the primary pathway involves NMN being converted to NR, which can then enter cells efficiently. Additionally, in mice, scientists have identified a specialized transporter called Slc12a8 that may allow some direct NMN transport², though this pathway’s significance in humans is still being studied³.

The conversion of NMN to NAD+ primarily occurs in the cytoplasm, with contributions to the nucleus and mitochondria. This widespread distribution is important because these are exactly where NAD+ is needed most – the nucleus for DNA repair, mitochondria for energy production, and cytoplasm for various metabolic processes. When you supplement with NMN, you’re essentially providing your cells with the raw material they need to produce NAD+ wherever it’s required most.

Understanding NMN’s role in NAD+ production has become increasingly important as research reveals just how central NAD+ is to cellular health. From powering fundamental metabolic functions to activating critical proteins like sirtuins (sometimes referred to as “longevity genes”), NAD+ influences hundreds of biological processes. This explains why declining NAD+ levels can have such widespread effects on health and aging – and why replacing those lost levels through NMN supplementation has generated so much scientific interest.

Key Takeaway: NMN serves as a highly efficient precursor that cells can readily convert into NAD+, a molecule essential for cellular health and longevity.

NMN to NAD+ Conversion Timeline

Timeline infographic showing the conversion of NMN to NAD+

The Anti-Aging Effects of NMN

The potential of NMN to combat aging extends far beyond simple supplementation – it appears to work at the very foundation of cellular health. By boosting NAD+ levels, NMN triggers a cascade of biological effects that have the potential to influence virtually every aspect of age-related decline.

Cellular Rejuvenation

NMN activates sirtuins (our “longevity genes”), which promote cellular health and resilience as we age⁴
Aging mitochondria become less efficient, but NMN helps restore their function⁵, promoting cellular energy production

Metabolic Enhancement

Research shows NMN helps maintain a healthy weight trajectory with age – not through quick fixes, but by fundamentally improving energy processing⁶
NMN appears to improve insulin sensitivity⁷, addressing one of aging’s most common metabolic challenges

Heart and Vessel Health

Studies reveal NMN’s ability to rejuvenate aging blood vessels and reduce arterial stiffness⁸
NMN promotes angiogenesis and improves blood flow, particularly in older subjects⁹

Brain and Cognitive Function

Research indicates potential protective effects against age-related cognitive decline¹⁰
Supports reduction of oxidative stress in neural tissues¹¹

Additional Benefits

Preserves muscle strength and endurance in older adults¹²
Shows promise in supporting long-term ocular function¹³

Human Research Validation

While many studies come from animal research, human trials are increasingly confirming NMN’s potential:

A landmark Japanese study confirmed increased NAD+ metabolites in human blood after supplementation¹⁴
Clinical trials show improvements in physical ability and cardiovascular health markers¹⁵
A notable study with postmenopausal women demonstrated improved insulin sensitivity after just 10 weeks¹⁶

What makes these findings particularly exciting is their comprehensive nature – NMN doesn’t just target a single aspect of aging but appears to address multiple facets simultaneously. This broad-spectrum approach to age-related decline aligns with our growing understanding that aging itself is a multifaceted process requiring equally sophisticated interventions.

Key Takeaway: NMN shows promise as a comprehensive anti-aging intervention by targeting multiple aspects of aging simultaneously, from cellular health to metabolism, with growing support from human trials.

Can You Get NMN Naturally?

While NMN occurs naturally in various foods, the concentrations are typically quite modest. The highest natural sources include edamame (soybeans), broccoli, cabbage, cucumber, and avocado. Some animal products, particularly beef and raw salmon, also contain trace amounts. However, even the richest dietary sources provide NMN in quantities far below what research suggests is needed for meaningful biological impact.

To put this in perspective, edamame – one of the most concentrated natural sources – contains approximately 1.88 mg of NMN per 100 grams. Most clinical studies exploring NMN’s benefits use daily doses ranging from 250 mg to 1,000 mg. This means you would need to consume unrealistic quantities of even the richest food sources to approach the levels used in research. Moreover, NMN in food can be unstable and may degrade during cooking or processing, further limiting its biological availability.

This significant gap between dietary intake and therapeutic dosing explains why supplementation has become the primary focus of NMN research and practical application. While maintaining a diet rich in natural NMN sources supports overall health, supplementation remains the most viable approach for achieving meaningful increases in NAD+ levels, particularly as we age.

Benefits of NMN Supplementation

In an era where we understand aging as a complex biological process rather than an inevitability, NMN has captured scientists’ attention for a compelling reason: it helps restore NAD+ levels that naturally decline as we age. While we’ve explored how NMN works at the molecular level, what’s truly fascinating is how this cellular restoration translates into real-world health benefits.

Think of NAD+ as your cells’ master regulator – when its levels drop, it’s like having a city running on a failing power grid. NMN helps restore that grid, but the story doesn’t end with just keeping the lights on.

Research has revealed an impressive array of potential benefits that ripple out from this fundamental restoration. Here’s what scientists have recently discovered about how NMN’s NAD+-boosting properties may support your body’s vitality:

A 12-week study demonstrated that 250 mg/day of NMN significantly increased NAD+ and NAD+-related metabolite concentrations in whole blood of healthy older men. The same study showed partial improvements in muscle performance, evaluated using gait speed and grip strength in healthy older men¹⁷.
A 60-day study found statistically significant increases in walking distance during a six-minute walking test for groups taking 300 mg, 600 mg, and 900 mg of NMN compared to placebo¹⁸. The trial observed statistically significant improvements in SF-36 scores, which measure quality of life.
A 12-week study using 250 mg/day of NMN observed a tendency for decreased pulse wave velocity values, indicating potential reduction in arterial stiffness¹⁹.
A study in pre-aging mice found that NMN supplementation significantly increased heat yield after 40 days, suggesting pro-metabolic effects. The same study found that NMN supplementation was associated with elongation of telomere length in peripheral blood mononuclear cells (PBMCs)²⁰.
A long-term study published in June of 2024 examined the effects of chronic NMN treatment started in middle-life. NMN treatment increased lifespan and healthspan in a sex-dependent manner. Both sexes showed delayed frailty and significant increases in the gut bacterial species A. colihominis. Female mice demonstrated an increase in lifespan, while male mice showed improvements in metabolic health and physical activity²¹.

When is the Best Time to Take NMN?

Most studies showing NMN’s benefits have participants taking it in the morning on an empty stomach. This timing may help optimize absorption since NMN doesn’t have to compete with other nutrients. However, some people report more noticeable energy effects when taking it with breakfast or their first meal.

If you’re using NMN primarily for metabolic support, consider taking it about 30 minutes before exercise. This timing aligns with your body’s natural increase in NAD+ demand during physical activity. However, if you’re more focused on its long-term longevity benefits, consistency matters more than precise timing.

A practical tip: Since NMN can influence energy levels through its effects on cellular metabolism, some people prefer to avoid taking it too close to bedtime. If you’re taking multiple doses, try spreading them across the first half of your day.

The most important factor isn’t necessarily the exact hour you take NMN, but rather maintaining consistent daily supplementation. NAD+ levels build up over time, and the most significant benefits appear to come from steady, long-term use rather than perfect timing.

Who Should Not Take NMN?

While NMN shows promise for healthy aging, certain groups should consult their healthcare provider before starting supplementation or may need to avoid it entirely:

Pregnant or nursing women should avoid NMN due to insufficient safety data.
Those undergoing cancer treatment should also exercise caution, as NAD+ metabolism can affect cancer cell behavior.
People with autoimmune conditions should speak with their doctor first, since NMN may influence immune system function.
Individuals taking medications that affect NAD+ metabolism should get medical clearance before starting NMN.

If you have a history of severe allergic reactions to supplements, are under 18, or have significant liver or kidney problems, work with your healthcare provider to determine if NMN is appropriate for you.

Is NMN Safe? Are There Side Effects?

Multiple randomized, double-blind, placebo-controlled studies have assessed NMN’s safety:

A 60-day trial with 80 middle-aged adults using doses of 300 mg, 600 mg, or 900 mg daily found no safety issues based on adverse events monitoring and laboratory measures²².
A 12-week study with 30 participants taking 250 mg NMN daily reported no abnormalities in physiological and laboratory tests²³.
A 4-week trial with 31 healthy adults taking 1250 mg NMN daily showed no changes exceeding physiological variations in multiple clinical analyses²⁴.

Clinical biochemical, hematological, and urinary tests conducted during these trials did not reveal any significant adverse effects attributable to NMN supplementation. No severe adverse events were observed in the studies, and NMN was well-tolerated by participants across various dosages.

NMN supplementation has demonstrated good tolerability. Doses ranging from 250 mg to 1250 mg daily were well-tolerated by study participants. No dropouts due to adverse events were reported in the reviewed studies, indicating good tolerability.

The available clinical evidence suggests that oral NMN supplementation is safe and well-tolerated in healthy adults at doses up to 1250 mg daily for periods ranging from 4 to 12 weeks. However, as with any supplement, individual responses may vary, and it’s advisable to consult with a healthcare professional before starting NMN supplementation.

How to Choose an NMN Supplement

When selecting an NMN supplement, several key factors determine both quality and effectiveness. Pure NMN powder represents one of the most common and well-studied forms of supplementation, though tablets and capsules are also widely available. Each form has its considerations:

Pure powder offers precise dosage control and typically provides excellent absorption rates. Quality and purity become especially important considerations with powder forms. When choosing powder supplements, look for products that undergo third-party testing and provide certificates of analysis.
Tablets and capsules offer convenience and precise pre-measured doses, though absorption rates may vary depending on the specific formulation and additional ingredients used.

Regardless of the form chosen, several quality indicators should guide your selection:

Manufacturing standards: Look for supplements produced in GMP-certified facilities, ensuring consistent quality and purity standards.
Third-party testing: Independent laboratory verification helps confirm both purity and accurate labeling of active ingredients.
Stability measures: Since NMN can be sensitive to environmental factors, proper packaging and storage recommendations are essential for maintaining potency.

While single-ingredient NMN supplements are common, research shows that NAD+ production relies on multiple cellular pathways. Our Vitality ↑® NAD+ Booster harnesses this scientific understanding by combining proven NAD+ precursors NMN and nicotinamide with D-Ribose and Creatine to support optimal cellular energy production. All of our supplements are produced at a GMP-certified manufacturing facility, ensuring quality, safety and consistency.

Ultimately, the ideal supplement choice depends on your specific health goals, budget, and preference for delivery method.

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NMN vs NR

When comparing NMN to NR, it’s important to understand their relative positions in the NAD+ production pathway. While both molecules serve as NAD+ precursors, NMN is actually one step closer to NAD+ in the biological conversion process, as NR must first be converted to NMN before becoming NAD+.

Some research suggests this might make NMN more efficient, though both compounds have demonstrated effectiveness in raising NAD+ levels. Early studies comparing the two precursors have shown promising results for both, but it’s worth noting that research directly comparing these compounds is still ongoing, and individual responses to each supplement can vary based on factors like age, metabolism, and overall health status.

FAQs About NMN

Will NMN reverse aging?

While NMN shows promise in supporting healthy aging processes, it’s important to understand that it doesn’t “reverse” aging in the literal sense. Research indicates that NMN can help maintain cellular health and potentially slow certain aspects of age-related decline by supporting NAD+ levels, but it’s not a fountain of youth. Think of it more as a tool for supporting healthy aging rather than reversing the aging process itself.

Is NMN just vitamin B3?

While NMN is related to vitamin B3 (niacin), it’s a distinctly different molecule. NMN is a more complex compound that includes vitamin B3 (in the form of nicotinamide) plus a ribose sugar and a phosphate group. This specialized structure makes it a direct precursor to NAD+, allowing it to serve different biological functions than simple vitamin B3 supplementation.

Can I take NMN and resveratrol together?

NMN and resveratrol are often used together as complementary supplements. While NMN helps increase NAD+ levels, resveratrol activates sirtuins, which require NAD+ to function. This combination is popularized by researchers like David Sinclair, who takes both supplements as part of his daily routine.

Does NMN need to be sublingual?

While some people prefer sublingual administration, clinical studies showing NMN’s benefits have primarily used oral supplementation through regular capsules or powder. Current research doesn’t definitively show that sublingual delivery is necessary for effectiveness.

Should NMN be stored in the refrigerator?

NMN is relatively stable at room temperature when properly packaged, but refrigeration may help maintain potency over longer periods, particularly for powder forms. Check your specific product’s storage recommendations, as stability can vary based on formulation and packaging.

Can I take NMN with caffeine?

There are no known negative interactions between NMN and caffeine. Some users report combining them improves their energy and focus, though this is anecdotal. If you’re sensitive to stimulants, consider taking NMN separately from caffeine to better assess your individual response to each.

How long does it take to feel NMN’s effects?

Individual experiences vary significantly. Some people report noticing improved energy and mental clarity within days, while others may take several weeks to experience benefits. The most scientifically validated effects, particularly those related to aging and metabolism, typically require consistent supplementation over months.

What happens if I stop taking NMN?

Stopping NMN supplementation doesn’t cause withdrawal effects. Your body will continue producing NAD+ naturally, though levels may gradually return to your baseline. Any benefits experienced while supplementing may slowly diminish over time without continued use.

Is NMN toxic to the liver?

Clinical studies have not shown any liver toxicity from NMN supplementation at recommended doses. Multiple safety studies, including those examining liver function markers, have demonstrated good tolerability of NMN in doses up to 1250mg daily. However, as with any supplement, individuals with pre-existing liver conditions should consult their healthcare provider before starting NMN.

Does NMN increase testosterone?

A notable study in boars found NMN supplementation increased testosterone levels and improved reproductive health markers, including sperm quality²⁵. The effects appeared to work through SIRT3 activation. While promising, human studies are still needed to confirm these benefits.

Referenced Sources

Does NAD+ Help With Menopause Symptoms?

Written by Jinfiniti Science on December 6, 2024. Posted in Menopause, NAD, NAD+, NAD+ Precursors. No Comments on Does NAD+ Help With Menopause Symptoms?

Hot flashes, night sweats, mood swings, sleep disturbances, and memory loss—these are just a few of the challenging symptoms women experience during menopause.

While they are often considered a natural part of the transition, these symptoms can severely impact your daily life, leaving you feeling drained, frustrated, and disconnected from your usual self.

The good news is that you don’t have to just accept them. There are effective ways to manage—and even alleviate—these discomforts.

One promising approach involves a critical coenzyme called NAD+ (nicotinamide adenine dinucleotide). Replenishing your body’s NAD+ and supporting cellular health may ease and even alleviate menopause symptoms, helping you feel more like yourself during this transition.

In this article, we discuss…

How menopause symptoms impact daily life and why they shouldn’t be accepted as inevitable
The connection between NAD+ depletion and ovarian aging through CD38 enzyme activity
How NAD+ supports key biological processes during menopause
Strategies for restoring NAD+ levels to manage menopause symptoms effectively

Common Symptoms of Menopause

Menopause is a natural phase in a woman’s life that marks the end of her reproductive years,¹ typically occurring in her late 40s to early 50s. During this time, estrogen levels fluctuate and eventually decline, leading to a range of physical and emotional changes, including:

Hot flashes and night sweats
Mood changes and irritability
Fatigue and low energy
Sleep disturbances
Cognitive issues (brain fog)
Vaginal dryness
Weight gain
Bone density loss
Lower libido
Loss of skin elasticity
Health problems due to hormonal changes

While these symptoms are often considered a normal part of aging, they can be overwhelming and disrupt your daily life. But you don’t have to simply endure them. By understanding what’s happening, you can take control and take proactive steps to help you live a healthy, balanced life—even during menopause.

NAD+ and Ovarian Aging

Ovarian aging is the gradual decline in ovarian function² that comes with age. As you enter your late 30s and 40s, changes in your hormones, such as reduced estrogen, can cause irregular periods and fewer high-quality eggs.

One of the reasons for this? A decrease in NAD+ levels as you age.

While NAD+ decreases across the body, the ovaries experience a more rapid decline³, affecting their function. This accelerated depletion of NAD+ is largely driven by an enzyme called CD38.

Research shows that CD38 activity increases in aging ovaries⁴, making them more vulnerable to a faster depletion of NAD+ compared to other tissues. This loss plays a major role in ovarian aging, leading to a decrease in ovarian follicles and a drop in estrogen production, which, in turn, causes common menopausal symptoms like hot flashes and mood swings.

But that’s not all. Low NAD+ levels in the ovaries are linked to a range of issues that affect reproductive health, including:

Reduced egg (oocyte) quality
Follicle depletion
Changes in gene expression related to aging, DNA repair, and inflammation

In fact, a recent study published in Ovarian Research found that low NAD+ levels can impair the energy metabolism of oocytes⁵, reducing their metabolic activity and impacting egg quality. This decline can have a major effect on fertility and reproductive health.

In addition to these metabolic changes, reduced NAD+ also alters gene expression in the ovaries, particularly genes involved in cellular aging and inflammation⁶. This creates a cycle that accelerates the aging process, leading to further declines in reproductive health.

Here’s the good news: you can turn things around.

By targeting CD38, you can potentially reverse some of the damage caused by NAD+ depletion in the ovaries. This has been shown in a study published in Nature, where researchers found that inhibiting or deleting CD38 significantly boosts NAD+ levels in the ovaries⁷, helping improve egg quality and even preserving fertility in aging mice.

This research suggests that by raising NAD+ levels and regulating CD38, you can significantly support ovarian health and even preserve fertility as you age. CD38 can be inhibited by flavonoids like apigenin and quercetin⁸, which is a main ingredient in our SenoAid senolytic supplement.

Key Takeaway: Research suggests that declining NAD+ levels in aging ovaries, driven by increased CD38 enzyme activity, significantly impact reproductive health and fertility, but targeting CD38 with specific compounds may help preserve ovarian function.

How NAD+ Can Relieve Menopause Symptoms

Maintaining optimal NAD+ levels during menopause is associated with several biological processes that influence common symptoms:

Cellular energy production: NAD+ serves as a critical coenzyme in mitochondrial function, directly impacting energy levels and fatigue resistance
Brain cell efficiency: Adequate NAD+ helps support neuronal health and cognitive function through enhanced mitochondrial activity and SIRT1 activation
Circadian rhythm regulation: NAD+ is essential for proper circadian rhythm function through the NAMPT-mediated salvage pathway, influencing sleep patterns
Cellular repair mechanisms: NAD+ enables DNA repair processes through PARP activation, supporting overall cellular health
Metabolic function: As a key metabolic regulator, NAD+ helps maintain efficient energy utilization and metabolic flexibility

While NAD+ levels naturally decrease during menopause, maintaining optimal cellular concentrations can support the body’s ability to manage this transition effectively.

NAD+ and Libido During Menopause

When you reach menopause, it’s not just the hot flashes and sleepless nights that can throw you off—it’s your libido, too. If you’ve been feeling a little less interested, you’re not alone.

But why does this happen?

The answer lies in NAD+. As we went over earlier, our NAD+ levels naturally decline with age, and this affects many processes in our bodies, from energy production to hormone regulation.

As menopause sets in, declining levels of estrogen and testosterone can naturally lower your sex drive even more. On top of that, reduced NAD+ levels can leave you feeling drained, irritable, and stressed⁹—none of which help your desire.

Fortunately, increasing NAD+ might be just what you need to reignite that spark. Here’s why:

Hormonal Balance: NAD+ supports the hormones that drive your libido¹⁰, including estrogen and testosterone. By boosting NAD+ levels, you help keep those hormones in check.
Neuroprotection: NAD+ protects your brain and reduces oxidative stress¹¹, which can improve mood, lower stress, and promote arousal.
More Energy: NAD+ fuels your cells, boosting your overall energy¹² and giving you more vitality for intimacy.
Better Mood: By fighting fatigue and mood swings¹³, NAD+ helps you feel emotionally balanced and ready to enjoy a deeper connection.

With optimal support for your NAD+ levels, you can reclaim not just your energy and vitality but your libido as well, bringing back the passion you thought menopause had taken away.

Restoring NAD+ Levels Before and After Menopause

NAD+ precursors are compounds that our cells can use to generate new NAD+ molecules. The most well-studied and effective precursors include:

Nicotinamide Mononucleotide (NMN)
Nicotinamide Riboside (NR)
Nicotinamide (a form of vitamin B3)

Supplementing with these precursors has been shown in studies to raise NAD+ levels in tissues throughout the body. As we have already seen, restoration of NAD+ can help reignite the cellular engines that power our metabolism, repair damaged DNA, activate longevity genes, and enable our cells to function at more youthful levels.

For women seeking a comprehensive NAD+ restoration strategy, products that combine multiple precursors may offer additional benefits. Scientifically formulated supplements, like our Vitality ↑® NAD+ Booster, provide a synergistic blend of NMN, Nicotinamide, and other bioactive ingredients to optimize NAD+ production and support healthy aging processes through menopause and beyond.

Whether you are proactively planning for menopause or already navigating this transition, incorporating NAD+ precursors into your wellness routine can provide a foundational strategy for nourishing cellular vitality. By restoring and maintaining healthy NAD+ levels, you can equip your cells with the resources they need to thrive, empowering you to age with resilience and grace.

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Test Your NAD Levels Today

While research clearly shows the connection between NAD+ and menopausal health, every woman’s journey is unique. The key to creating a personalized approach lies in knowing your precise cellular NAD+ levels.

Our Intracellular NAD® test provides precise measurements of your cellular NAD+ levels, complete with a detailed personal report and expert recommendations. You’ll understand exactly where your levels stand compared to optimal ranges, enabling you to make targeted decisions about your health. Plus, you’ll gain access to an exclusive webinar with our chief scientist, Dr. Jin-Xiong She, to deepen your understanding of NAD+ and its role in aging.

Don’t let declining NAD+ levels control your menopause experience. Get tested today and take the first step toward a more balanced, energetic you.

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Referenced Sources:

Can NAD+ Help Treat Alzheimer’s Disease and Dementia?

Written by Jinfiniti Science on December 2, 2024. Posted in Memory Loss and Brain Fog, NAD, NAD+, NAD+ Precursors, Neurological Diseases. No Comments on Can NAD+ Help Treat Alzheimer’s Disease and Dementia?

Alzheimer’s disease is affecting more people than ever, with 6.7 million Americans aged 65 and older living with it today. By 2050, that number is expected to more than double. Globally, over 55 million people are dealing with Alzheimer’s or other forms of dementia, creating challenges not just for them, but for their families too.

Right now, most treatments focus on managing symptoms, not fixing the root of the problem. That’s why there’s a growing push for new, more effective solutions—and nicotinamide adenine dinucleotide (NAD+) might be one of them.

NAD+ is the coenzyme behind every cell’s ability to thrive – it drives energy production, repairs DNA, and governs how your genes are expressed. As we age, NAD+ levels naturally decline, and this decrease is associated with neurodegeneration and cognitive impairment—hallmarks of conditions like Alzheimer’s disease.

A growing body of research is examining the relationship between NAD+ and neurodegenerative conditions, with studies suggesting that maintaining healthy NAD+ levels could help shield against the devastating effects of Alzheimer’s and dementia.

So, what makes this coenzyme so compelling for keeping our minds sharp as we age?

In this article, you will discover:

The critical relationship between NAD+ and neurodegeneration, exploring how this essential coenzyme impacts brain health at the cellular level
Clinical evidence supporting NAD+ supplementation in Alzheimer’s disease, including detailed research on nicotinamide, NMN, and nicotinamide riboside
Practical NAD+ treatment approaches, from IV therapy to scientifically-validated precursor compounds like Vitality ↑® NAD+ Booster
The importance of testing and monitoring NAD+ levels to proactively support cognitive health and prevent decline

The Link Between NAD+ and Neurodegeneration

Your cells rely on NAD+ like a conductor relies on their baton – the coenzyme coordinates numerous biological processes with precision that determines how well your body functions at its most fundamental level.

As we age, NAD+ levels in various tissues, including the brain, significantly decrease¹. This decline has been linked to the development of various age-related conditions, including neurodegenerative diseases like Alzheimer’s and Parkinson’s.²

NAD+ is essential for mitochondrial function and energy production. In neurodegenerative diseases, decreased NAD+ levels leads to multiple factors that contribute to neuronal death and axonal degeneration, hallmarks of these diseases:

Impaired mitochondrial function³
Increased reactive oxygen species (ROS) production⁴
Compromised cellular energy metabolism⁵
Impaired DNA repair mechanisms and reduced sirtuin activity⁶

The decline in NAD+ levels during aging and neurodegeneration is primarily due to:

Increased NAD+ consumption by enzymes such as CD38 and PARPs
Reduced expression of NAMPT, a key enzyme in the NAD+ salvage pathway
Activation of SARM1, a recently discovered NAD+ hydrolase that can rapidly deplete neuronal NAD+ levels⁷

Perhaps most intriguingly, reduction in NAD+ levels occurs before the onset of neurodegenerative symptoms, suggesting it may contribute to disease progression rather than being merely a consequence⁸.

Clinical Evidence for NAD+ in Alzheimer’s Disease

As Alzheimer’s disease (AD) becomes increasingly prevalent, researchers are exploring innovative therapies like NAD+ precursors to combat this devastating condition. But is NAD+ a potential treament for Alzheimer’s or just another overhyped trend? Let’s look at the evidence.

Nicotinamide (NAM) vs Placebo

A 2021 review published in Frontiers in Cell and Developmental Biology⁹ provides a comprehensive overview of the systematic therapeutic evidence for NAD+ and its precursors in Alzheimer’s disease models.

NAM, the amide form of vitamin B3, showed significant potential in seven preclinical trials for Alzheimer’s disease treatment:

NAM treatment improved spine density in neurons from AD mice, suggesting a neuroprotective role.¹⁰
A controlled delivery system of NAM reduced cognitive impairment and decreased phosphorylated tau in early-stage AD rats.¹¹
NAM pretreatment reduced expression of genes associated with AD and increased SIRT1 in brain tissues.¹²
NAM supplementation protected against Aβ-induced oxidative stress and reduced markers of cell death in rat AD models.¹³
Long-term NAM treatment improved cognitive performance, preserved mitochondrial integrity, and reduced AD pathology in mice.¹⁴
NAM reduced phosphorylated tau and prevented cognitive deficits in a mouse model of AD.¹⁵

More recently, a phase 2a proof-of-concept trial¹⁶ investigated the use of nicotinamide (a form of vitamin B3 and NAD+ precursor) in early Alzheimer’s disease:

47 participants received either 1500 mg of nicotinamide twice daily or placebo for 12 months.
Treatment resulted in significantly less change on the Clinical Dementia Rating-Sum of Boxes (CDR-SB) compared to placebo.
While not statistically significant, changes in cerebrospinal fluid (CSF) biomarkers favored nicotinamide.
The therapy showed a safe profile with balanced adverse events.

Nicotinamide Mononucleotide (NMN) vs Placebo

Outlined in the same 2021 review as above, NMN, a direct precursor to NAD+, has demonstrated efficacy in four AD models:

NMN improved memory in transgenic nematode AD models through a mechanism dependent on mitophagy.¹⁷
NMN treatment decreased Aβ production, synaptic loss, and inflammation in transgenic AD mice by inhibiting JNK activity.¹⁸
In Aβ-injected rats, NMN improved cognitive function, reduced neuronal cell death, and decreased oxidative stress.¹⁹
NMN reversed deficiencies in oxygen consumption and reduced levels of mutant APP in AD mice²⁰.

The most recent study, conducted by Fang et al. in 2019²¹, investigated the effects of NAD+ repletion on AD pathology using both animal models and human cell cultures.

The study found that NAD+ levels were significantly reduced in both the hippocampus and cerebral cortex of AD model mice. This depletion was associated with decreased activity of SIRT3, a NAD+-dependent deacetylase.

Restoring NAD+ levels through nicotinamide mononucleotide (NMN) administration:

Normalized NAD+ levels
Restored mitochondrial function
Reduced reactive oxygen species (ROS)
Decreased DNA damage
Improved neuroplasticity
Enhanced cognitive function in AD model mice

Nicotinamide Riboside (NR) vs Placebo

A study by Xie et al. published in Metabolic Brain Disease in 2019²² provides important evidence for the potential benefits of NR supplementation in Alzheimer’s disease and aging.

NR supplementation improved short-term spatial memory in aged mice and enhanced contextual fear memory in AD model mice.
NR inhibited the accumulation of amyloid-β (Aβ) in AD model mice and reduced the migration of astrocytes to Aβ plaques.
NR supplementation inhibited the activation of astrocytes in aged mice.
NR decreased the elevation of serum nicotinamide phosphoribosyltransferase (NAMPT) in aged mice, potentially indicating reduced inflammation.

Moreover, a 2020 review of the protective effects of NR against cognitive impairment²³ found that NR has shown the ability to:

Inhibit the accumulation of pathological hallmarks of Alzheimer’s disease
Improve learning and memory in various murine models for dementia
Reduce DNA damage, neuroinflammation, and apoptosis
Improve hippocampal synaptic plasticity in diabetic mice and an Alzheimer’s disease mouse model

The evidence paints an intriguing picture: declining NAD+ levels in brain cells appear to be a hallmark of aging and contribute significantly to the pathology of Alzheimer’s disease. Perhaps most exciting is the prospect that a simple, safe vitamin-based intervention could help protect our aging brains.

While more research is needed, the possibility of an accessible and affordable approach to neuroprotection offers hope in our ongoing fight against Alzheimer’s disease.

NAD Treatment Approaches

As we age and face increasing cognitive challenges, maintaining optimal NAD+ levels becomes an important piece of the puzzle for supporting brain health and potentially reducing the risk of Alzheimer’s and dementia. Here’s a look at two primary treatment approaches to optimizing your NAD+ levels for cognitive function and neuroprotection.

NAD IV Therapy

While NAD+ IV therapy has gained popularity in recent years, its efficacy in treating Alzheimer’s disease remains largely unproven. Current evidence is limited to a single case report where one patient showed subjective improvements in memory and overall attitude. It’s important to understand that NAD+ IV infusion primarily increases extracellular NAD+ levels, without necessarily improving intracellular concentrations where the molecule’s beneficial effects primarily occur.

Moreover, patients should be aware of potential side effects associated with NAD+ IV therapy. The invasive nature of IV administration and the lack of comprehensive clinical studies make this approach less favorable compared to other available options for supporting cognitive health.

NAD+ Precursor Compounds

In contrast to IV therapy, NAD+ precursor compounds have demonstrated substantial promise in scientific research, as detailed in our previous section. These compounds work by providing the building blocks your body needs to naturally increase cellular NAD+ levels, potentially supporting cognitive function and neurological health.

For those seeking an evidence-based solution to optimize their NAD+ levels, our NAD boosting supplement Vitality ↑® offers a clinically validated formulation that combines proven NAD precursors NMN and nicotinamide with D-ribose and creatine monohydrate.

This synergistic blend represents a significant advancement in NAD+ supplementation. The carefully selected ingredients work together to:

Enhance cellular NAD+ production
Support comprehensive cellular regeneration
Optimize energy metabolism
Promote cellular repair mechanisms

What sets Vitality ↑® NAD+ Booster apart is its superior efficacy compared to individual NAD+ precursors. Users consistently report notable improvements in their overall health and performance after achieving optimized NAD+ levels through this comprehensive formulation.

The clinical validation behind this unique combination of ingredients makes Vitality ↑® NAD+ Booster an excellent choice for individuals looking to support their cognitive health and potentially reduce their risk of age-related cognitive decline.

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Testing NAD+ Levels to Prevent Cognitive Decline

Just as regular health screenings help detect various medical conditions early, monitoring your NAD+ levels provides valuable insights into your cellular health—particularly in regions critical for cognitive function.

Research has established that declining NAD+ levels correlate strongly with cognitive deterioration and increased risk of neurodegenerative conditions. Think of NAD+ as your cells’ essential energy currency—when levels drop, cellular functions begin to falter, potentially contributing to:

Reduced neural repair and maintenance
Decreased energy production in brain cells
Compromised DNA repair mechanisms
Impaired cellular stress response

Our Intracellular NAD® Test offers a precise measurement of NAD+ levels where it matters most—inside your cells. Unlike conventional testing methods that may only capture extracellular NAD+, our innovative approach provides:

Accurate measurement of cellular NAD+ concentrations
Comprehensive analysis of your metabolic health
Early detection of potential NAD+ deficiencies
Personalized insights for optimization strategies

Don’t wait until cognitive changes become apparent. Understanding and optimizing your NAD+ levels today could play a role in maintaining your cognitive health tomorrow. Begin your journey toward optimal brain health with the Intracellular NAD Test—your window into cellular wellness and cognitive longevity.

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Referenced Sources:

Revolutionizing America’s Health: My Journey and Shared Vision with RFK Jr.

Written by Jinfiniti Science on November 28, 2024. Posted in Guest Blog, Obesity and Weight Gain. No Comments on Revolutionizing America’s Health: My Journey and Shared Vision with RFK Jr.

America is facing a health crisis of epic proportions. Chronic diseases like obesity, diabetes, and heart disease have become the norm rather than the exception.

Our food system is flooded with ultra-processed, nutrient-devoid products, and the healthcare system focuses more on treating symptoms than addressing root causes.

For decades, I lived as both a victim of this broken system and an unwitting contributor to it. My journey—from battling obesity to pioneering solutions—led me to a revelation: we can, and must, Make America Healthy Again (MAHA).

What started as a personal battle turned into a movement, one that aligns closely with leaders like Robert F. Kennedy Jr., who dares to question the status quo of our healthcare and food systems.

RFK Jr. has famously spoken out about the inadequacies of medical practices and government policies, shedding light on the systemic failures that perpetuate poor health. I share his passion for truth and reform. Together, our shared mission is to empower Americans to reclaim their health—not through fads or gimmicks, but through education, real food, and science-backed solutions.

The Early Struggles: Living the Problem I Wanted to Solve

My name is Chuck Nix, and my journey to health advocacy has been a long road of personal struggle, revelation, and relentless perseverance. Born in Dallas, Texas, in 1959 and adopted at birth, I grew up in a household where processed and junk food reigned supreme.

Although my adoptive parents were normal weight, I quickly became one of those rare, chubby kids in my era. Food was comfort, habit, and, unknowingly, the root of my lifelong health challenges.

By ninth grade, I weighed 210 pounds at 5’9″ and was already struggling with my weight and the desire to fit in. I attempted my first “diet” then, starving myself to lose weight, but I was constantly hungry, and the weight just came back. This set off a decades-long cycle of yo-yo dieting, reaching extremes.

As an adult, standing at 6’2″, I hit a low of 160 pounds in 1985 through intense exercise and strict calorie restriction. But it was unsustainable—I was thin, not fit, and the weight eventually crept back on.

My weight was a constant battle—one that followed me through every phase of life. I tried calorie restriction, extreme exercise, and countless diets, all while following the outdated, low-fat, high-carb dietary advice of the time.

Over the years, my weight fluctuated wildly, reaching a high of 315 pounds in 2018. I nearly died that year. In my 20s and 30s, I tried everything I could think of: severe calorie restriction, sometimes eating only 1200 calories a day, paired with hours of exercise. But high-stress jobs and lack of time always led me back to quick meals at the drive-thru.

Every time I lost weight, I seemed to gain it back with a vengeance.

In 1991, I met my biological family, and what I saw was eye-opening: my biological mother’s side of the family was obese, with one of my half-brothers even reaching 465 pounds. It was a warning of what could have been me without discipline.

Around this time, I made a serious effort to get fit, following the low-fat advice of doctors, working out at two gyms, and jogging five miles daily. After six years of dedication, I’d only managed to get down to 240 pounds. I felt like a failure, but little did I know, I had been misled.

The turning point came in late 1999 when I discovered the Atkins Diet.

The initial “induction phase” was ketogenic, and in just 3.5 months, I lost 60 pounds with zero exercise. I felt fantastic for the first time in years and was determined to finally achieve the fit, healthy body I had chased for so long.

I hired a personal trainer, but he warned me that Atkins was dangerous and could destroy my liver and kidneys. Trusting his advice, I compromised, adding more carbs.

The result? I gained 40 pounds of fat and became re-addicted to carbs. I ended up suing the gym and got my money back, but I felt utterly defeated.

For decades, I believed I was failing, but in reality, the system was failing me.

Science now shows that the food pyramid we were taught to follow in the 1980s was built on flawed assumptions and industry influence. High-carb, low-fat diets were a recipe for insulin resistance, metabolic disorders, and cravings that kept us dependent on sugar-laden foods.

My health continued to spiral. By 2003, I’d made a career shift and finally achieved a dream of mine: founding my frozen dessert company, Silky Smooth Frozen Custard.

This was the first Wisconsin-style frozen custard shop in Beverly Hills, and later evolved into Silky Smooth MicroCreamery, which won “Best Ice Cream in LA” in 2007.

The shop attracted celebrities like Kim Kardashian and Tyra Banks, but it all came crashing down with the Great Recession in 2008. I lost everything—my business, my credit, my hope. From there, I hustled in the world of credit funding, eventually building up to a six-figure business. And then COVID hit, and it all crumbled once again.

The Breakthrough: Science Meets Personal Experience

In 2016, I stumbled across the show My Diet is Better Than Yours, which highlighted the ketogenic diet, helping a man in his late 50s lose significant weight.

I was angry—had I been lied to all those years? More research led me to Dr. Eric Berg, who taught me the truth about keto and intermittent fasting. I finally found an approach that worked for me, dropping 100 pounds in nine months with no exercise.

I felt decades younger, but more importantly, I felt in control for the first time. I learned that sugar was poison, and I became determined to help others find freedom from it.

Armed with this new knowledge, I decided to bring back my dessert brand as an all-keto operation. I spent years developing SilkySweet®, an all-natural, sugar-free sweetener that tasted better than cane sugar and cured my own sugar cravings.

SilkySweet® was originally created to replace the “forced by law” use of Sucralose in Silky Smooth frozen desserts, reformulating them to meet future Ketogenic Certified health standards. Through extensive R&D, we developed a formula superior to cane sugar, leading me to market it globally as the ultimate, realistic cure for sugar addiction.

I even created SilkySweet KetoCola, a sugar-free cola that was preferred three to one over Mexican Coca-Cola in taste tests. Despite my breakthroughs, COVID delayed production, inflation spiked, and my business struggled to take off. Personal credit was once again destroyed, and I faced setback after setback.

From Personal Mission to National Movement

In 2022, I had a moment of clarity: my mission was bigger than just selling products. I needed to help Americans break free from the toxic food system that was driving chronic disease and obesity.

Inspired, I initially came up with the concept of “Make America Healthy Again” (MAHA) and created a prototype purple hat to symbolize unity by merging red and blue.

However, I soon evolved the phrase to “Making America Healthy Again” and produced 500 hats.

The shift from “Make” to “Making” reflects a move from a campaign promise—set to expire on 11/5/24—to an active, ongoing mission of healing and curing, embodied by the world’s only realistic solution for sugar addiction: SilkySweet.com.

Like many breakthrough ideas that show up concurrently in different geographic areas and even cultures, this vision, MAHA, caught fire with movers and shakers, including Robert F. Kennedy Jr., long a champion of health reform.

The first purple MAHA hats symbolized my call for unity across all demographics and political divides, with red and blue merging into purple, a call for health transformation and healing in America.

In 2023 I took a gamble and exhibited at an anti-aging/health event. I caught the bug and got Longevity Fever.

I immersed myself in education and made contacts that have proven very beneficial for my MAHA movement. I had been taking an NAD+ supplement that was not working and discovered Jinfiniti Precision Medicine and their Vitality Boost NAD+ “Optimizer.” (The technical description of the product is actually NAD+ Booster supplement. These are the things you learn when you take the deep dives!)

Like so many other consumers who believe that all supplements are created equal, I got schooled in the importance of using data-driven, science-backed products, and in particular, the need to optimize my intracellular NAD.

I met Dr. Jin-Xiong She, Jinfiniti’s Founder and Chief Scientist.

Jinfiniti’s Special Projects Director, Greta Blackburn, was moderating a panel at the event and, upon hearing of my mission, introduced me to her panel member Dr. Robert Lufkin, author of “Lies I Taught In Medical School’ and a USC Professor. Dr. Lufkin and I shared so many common beliefs and he, like Dr. Eric Berg, who set me straight on Keto, are part of my semi-official Advisory Team as the mission moves forward.

Dr. Lufkin and I touched base only briefly at that ’23 event but at the same event the following year we had time to share some conversations and today I reach out to him regularly for his expertise and highly material insights for the MAHA cause.

In 2024, something remarkable happened. After switching to a full carnivore diet, I received life-changing blood test results and adjusted my macros to 80% fat.

Almost overnight, my vision, which had been compromised since I was a child, transformed. My eyesight returned sharper than ever—20/10 in both eyes—and I could see in 3D for the first time since childhood, all without the need for glasses or contact lense.

I knew then that my mission was not only to heal myself but to bring real health solutions to every American.

The RFK Jr. Connection: A Shared Vision for Health Reform

In September 2024, I took MAHA to the Senate hearings in Washington, D.C., where I met Senator Ron Johnson, and Calley and Casey Means. Thanks to a friend who helped with travel costs, I witnessed firsthand the growing momentum for healthcare reform. I knew that MAHA was not just a vision but a movement with real potential to change lives.

It was recently announced that RFK Jr. is being appointed as the next Secretary of Health and Human Services. I am excited about the possibilities for my MAHA mission combined with his.

Sometimes we feel that our ideas, journeys, and trials and tribulations are all for naught. I’m here to tell you that we can all use our passion as fuel to make change. It takes work. It means sacrifice, but in the end, miracles can happen, relationships can be forged, and change can happen.

Today, I work alongside pioneers like Dr. Jin-Xiong She, who introduced me to Jinfiniti’s anti-aging supplements, and Greta Blackburn- formerly known as The Telomere Diva for her part in the launch of TA Sciences, and for her role in developing and co-writing the layman’s book on telomeres, “The Immortality Edge”– who immediately saw the potential in MAHA.

Greta now calls herself a NAD Nerd and a MAHA Mafiosa!

Together, we’re pushing forward with the vision to Make America Healthy Again, one taste bud and one American at a time.

My journey has been filled with struggles, but each one has brought me closer to this mission. As I stand here today, with my iconic purple MAHA hat and years of hard-earned wisdom, I’m more committed than ever to making this vision a reality.