Author: Jinfiniti Science

NMN and NR Compared: Better Together or Choose One?

Written by Jinfiniti Science on November 26, 2024. Posted in NAD, NAD+, NAD+ Precursors. No Comments on NMN and NR Compared: Better Together or Choose One?

What if the secret to feeling younger and staying healthier lies within your cells?

Meet NAD+ (nicotinamide adenine dinucleotide) — a dynamic coenzyme that keeps your body running at its best. From energy production to repairing DNA and maintaining cellular health, NAD+ is a driving force behind a myriad biological processes that impact how you feel and function every day. But as we age, our NAD+ levels decline, leading to slower metabolism, fatigue, and other age-related challenges.

While our cellular fuel tanks deplete as we get older, scientists have identified two key compounds that may help refill it: nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). These precursor molecules act as building blocks for NAD+, offering a potential solution to age-related NAD+ decline. With mounting evidence supporting their efficacy, NMN and NR are rapidly becoming central figures in the field of longevity research

The scientific community has been working to determine which of these compounds might be more effective at boosting NAD+ levels – and the answer isn’t so straightforward. Each precursor has unique properties and cellular pathways, leading us to explore an intriguing possibility: could combining NMN and NR together offer advantages that neither compound can achieve alone?

In this article, you will learn:

The fundamental differences between NMN and NR as NAD+ precursors, including their unique molecular structures and how they’re processed differently in your body’s cells
How bioavailability impacts the effectiveness of these supplements, including the complex roles of transporters, enzymes, and gut bacteria in their absorption
What clinical research reveals about both compounds’ effectiveness and safety profiles, with data from human trials showing their impacts on NAD+ levels and health outcomes
How to make an informed choice between NMN, NR, or a combination approach based on your specific health goals, supported by cellular-level testing to optimize your supplementation strategy

NMN vs NR: Different Precursors, Different Pathways

NMN and NR are two of the most well-known NAD+ precursors, studied fairly extensively for their ability to increase NAD+ levels, support cellular energy, and promote long-term health. But while they share a common goal, their unique structures and metabolic pathways set them apart in how they influence your body’s health.

NMN is a larger molecule made up of a nicotinamide group attached to a ribose sugar and a phosphate group¹. This makes it more complex than NR, which is simply nicotinamide linked to ribose, without the extra phosphate².

This structural difference is critical in how each precursor is absorbed and utilized. For example, NMN can be directly absorbed by cells in some tissues, but in other tissues, it needs to be converted into NR before entering cells. NR, on the other hand, can be directly converted into NMN inside the cell.

The pathways that transform NMN and NR into NAD+ also follow different processes. NMN is primarily synthesized in the cell through a process called the salvage pathway³, where it’s created from nicotinamide with the help of an enzyme called NAMPT. Once inside the cell, NMN is converted to NAD+ through another enzyme, NMNAT.

In contrast, NR is phosphorylated by NR kinases (NRK1/NRK2) to form NMN,⁴ which then goes through the same process to become NAD+. Additionally, NR is absorbed by cells through specific transporters or can be metabolized in the gut to nicotinamide, which also contributes to NAD+ production.

Both NMN and NR are highly effective at increasing NAD+ levels, but their structural and metabolic differences can influence absorption efficiency and how quickly they act in the body. NMN’s ability to bypass certain steps may make it more effective in specific tissues, while NR’s smaller size allows for broader cellular uptake.

Choosing the right precursor depends on your health goals and how your body responds to each. Understanding these distinctions can help you tailor your approach to boosting NAD+, supporting cellular repair, and combating the effects of aging.

Key Takeaway: While both NMN and NR effectively boost NAD+ levels, their distinct molecular structures and metabolic pathways (with NMN being larger and containing an extra phosphate group compared to NR) lead to different absorption mechanisms and cellular utilization patterns in the body.

Bioavailability of NR and NMN

To truly benefit from NAD+ precursor supplementation, absorption is everything. So here’s the burning question: when it comes to NR versus NMN, which one does your body soak up like a sponge—and which one might just take an express trip to your bladder?

The bioavailability of NR and NMN is more complex than initially understood, and recent research has challenged some earlier assumptions about how these compounds are processed in the body.

Both NR and NMN undergo complex metabolic transformations before contributing to NAD+ synthesis. While earlier theories suggested NR might have superior absorption due to its smaller size⁵, current evidence paints a more nuanced picture. NR is likely absorbed intact and enters cells via equilibrative nucleoside transporters, where it’s converted to NMN.

Conversely, NMN may be directly transported into cells through a recently identified transporter (SLC12A8) in mice⁶, though its function in humans isn’t yet fully understood. Often, NMN is dephosphorylated to NR before cellular entry, then reconverted to NMN inside the cell⁷.

The metabolic pathway involves multiple steps influenced by various factors, including gut bacteria. The microbiome can deamidate NMN to nicotinic acid mononucleotide (NAMN), affecting its overall absorption and utilization⁸. While both compounds can be converted to nicotinamide (NAM), this isn’t the sole pathway. The process is more intricate than previously thought, involving a complex interplay of enzymes and transporters.

Clinical studies have demonstrated that both NR and NMN supplements can effectively increase NAD+ levels in human tissues, though their impact varies based on factors such as dosage, duration of use, and individual physiological differences.

Key Takeaway: While both NR and NMN can effectively boost NAD levels, their absorption and utilization involve complex, interconnected pathways influenced by multiple factors including transporters, enzymes, and gut bacteria, making a simple comparison of their bioavailability more nuanced than previously thought.

Is NMN or NR More Clinically Effective?

Both NMN and NR promise to boost your cellular energy and longevity, but which one delivers better results where it matters most – in clinical studies? Let’s examine the evidence.

Clinical Scorecard for NR

Safety Profile in Human Trials: In a randomized, double-blind, placebo-controlled trial involving 1000 mg/day of NR supplementation for six weeks, participants reported no significant adverse events, indicating a favorable safety profile⁹ (Baur et al., 2019). Another study found that NR was well tolerated at doses up to 3000 mg/day without serious side effects.¹⁰
NAD+ Elevation Capabilities: Research demonstrates that NR supplementation can significantly elevate NAD+ levels in human subjects. One study reported a ~60% increase in NAD+ concentrations after just six weeks of NR¹¹ supplementation. Another trial showed that a single dose of NR increased NAD+ levels within hours,¹² confirming its rapid bioavailability.
Beneficial Outcomes: Clinical trials have shown that NR supplementation leads to improved metabolic health markers¹³, including enhanced insulin sensitivity and reduced blood pressure. Participants in one study exhibited improvements in physical performance, with a notable increase in walking distance during a six-minute walk test after NR supplementation. Another study indicated improvements in lipid profiles and overall cardiovascular health¹⁴ following NR intake.

Clinical Scorecard for NMN

Safety Profile in Human Trials: NMN has demonstrated a strong safety profile in clinical trials. A study involving 250 mg/day of NMN over 12 weeks reported no significant adverse effects among participants¹⁵, indicating it is well tolerated. Another trial with doses up to 900 mg/day also confirmed the absence of serious side effects, further supporting its safety¹⁶.
NAD+ Elevation Capabilities: NMN supplementation has been shown to effectively elevate NAD+ levels in humans. In one human clinical trial, participants taking NMN experienced significant increases in blood NAD+ concentrations at both day 30 and day 60 of supplementation¹⁷. Another study found that NMN doses as low as 300 mg/day could lead to substantial increases in NAD+ levels compared to placebo.¹⁸
Beneficial Outcomes: Participants in NMN clinical trials have shown improvements in physical performance metrics, such as increased walking distance during exercise tests¹⁹. NMN has also been associated with better metabolic health indicators, including reduced arterial stiffness and improved cardiovascular function²⁰.

In sum, both precursor molecules have proven their worth in the clinical arena – they just might suit different individuals based on specific health goals and preferences.

Choosing Between NMN and NR Supplements

With an understanding of the differences between NMN and NR, we now face a common question: which one should you choose as a dietary supplement?

While both molecules ultimately raise NAD levels, their distinct cellular uptake mechanisms and tissue preferences can lead to varying individual responses. Let’s explore the specific advantages of each approach, comparing NMN with NR, and why some advocate for using both together.

The Case for Nicotinamide Riboside

NR has established itself as a well-researched NAD+ precursor with an impressive track record of human clinical trials supporting its safety and efficacy. As a smaller molecule than NMN, NR may have advantages in terms of cellular uptake in certain tissues, particularly in the brain and nervous system. Its metabolism is well-understood, with specific transporters identified in various cell types, and it has demonstrated promising results in studies focused on cognitive function, muscle performance, and metabolic health.

For those seeking a thoroughly studied option with a clear safety profile and established manufacturing processes, NR represents a compelling choice.

The Case for NMN Supplements

NMN supplements offer potential advantages in certain cellular contexts, particularly in tissues that express specific NMN transporters like the Slc12a8 transporter found in the small intestine. Some researchers believe that because NMN is just one step away from becoming NAD+ (whereas NR requires an additional conversion step), it may provide more direct benefits in certain tissues.

Recent human studies have shown promising results for NMN in areas such as muscle strength, endurance, and cardiovascular health, making it an attractive option for those focused on physical performance and metabolic enhancement.

The Case for Taking Both Together

A combination approach incorporating both NMN and NR may offer the most comprehensive strategy. Different tissues and cells throughout the body may preferentially utilize one precursor over the other, and using both ensures that you’re providing your body with multiple pathways to increase NAD levels.

While no direct comparative studies exist between the two molecules, the complementary nature of their uptake mechanisms and tissue distribution patterns suggests that a dual approach could maximize the potential benefits across various body systems. This strategy, while potentially more costly, provides a more complete approach that accounts for the body’s complex and varied cellular preferences.

For those interested in tapping into the combined power of multiple NAD precursors, our clinically validated Vitality ↑® NAD+ Booster offers a convenient all-in-one solution for improved levels of NAD. This scientifically formulated blend combines precisely dosed NMN and Nicotinamide with bioactive D-Ribose and Creatine to maximize NAD+ production, helping reinvigorate cellular energy production, support healthy aging processes, and optimizing overall vitality.

SHOP NAD+ BOOSTER

Is NR Better Than NMN for NAD+?

The debate over whether NR or NMN is the better choice for boosting NAD+ levels doesn’t have a clear-cut answer, and that’s okay. Both compounds offer unique benefits, each helping to raise NAD+ levels and improve metabolic health and cellular function. Rather than comparing them directly, it might be more useful to see them as complementary allies, each playing a part in supporting overall health.

Ultimately, whether you choose NR, NMN, or both, each offers great potential for improving your health and longevity. When used thoughtfully, they can complement each other, enhancing their benefits and helping you reach your wellness goals.

Before You Decide, Why Not Test Your NAD+?

Transform your NAD+ optimization journey with our groundbreaking Intracellular NAD Test. Our test is the only solution that measures NAD+ levels directly within your cells – where it matters most. This insight eliminates the guesswork and reveals your true NAD+ status with unprecedented accuracy.

Your test results provide a precise blueprint for supplementation: If your cellular levels are lower than optimal, NR or combinations might be your ideal starting point for efficiently raising NAD+. For those with healthy baseline levels, NMN could be the perfect choice to maintain and enhance your cellular vitality.

The unmatched precision of our Intracellular NAD Test becomes even more valuable over time. When you establish your baseline and monitor changes, you can fine-tune your supplement routine based on real, cellular-level data – a capability unavailable anywhere else. This pioneering approach ensures your investment in NAD+ supplements delivers targeted, measurable results for your health and longevity goals.

TEST YOUR NAD LEVELS TODAY

Referenced Sources:

The Complete Guide to Every NAD+ Precursor

Written by Jinfiniti Science on November 22, 2024. Posted in NAD, NAD+, NAD+ Precursors. No Comments on The Complete Guide to Every NAD+ Precursor

NAD+ stands at the center of nearly every major biological process in our cells. This remarkable coenzyme, known scientifically as nicotinamide adenine dinucleotide, enables energy production, DNA repair, and hundreds of other vital cellular functions. Without it, our cells would essentially stop working.

But there’s a hitch: our NAD+ levels naturally decline with age, dropping significantly by the time we reach our later years. This decline has been linked to many aspects of aging and metabolic dysfunction, spurring intense research into ways we can maintain healthy NAD+ levels throughout life.

Luckily, our bodies can synthesize NAD+ from several different compounds known as NAD+ precursors. These are specific molecules that our cells can convert into NAD+ through well-understood biological pathways. We’ve identified nine distinct precursors that can boost NAD+ levels in humans.

In this guide, you’ll learn about all nine established NAD+ precursors, from the well-studied workhorses like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) to the lesser-known players like tryptophan and dihydronicotinamide riboside (try saying that five times fast).

Each precursor has its own fascinating story, complete with advantages and quirks in how our bodies process them.

In this article, we discuss:

What NAD precursors are and how they can optimize your health for a vibrant, active future.
9 known NAD precursors that can elevate NAD levels for increased vitality and well-being.
Each precursor’s unique pathway to NAD+ production and key findings from studies.
How to measure your cellular NAD+ levels accurately and track the effectiveness of supplementation.

What are NAD+ Precursors?

If you’ve been researching ways to boost your NAD+ levels, you’ve likely encountered “NAD boosters” or NAD supplements in health and longevity discussions. But what exactly are these compounds, and how do they work?

NAD+ precursors are specific molecules that your body can convert into NAD+ through various biological pathways¹. They can be thought of as raw materials your cells need to manufacture NAD+. While all nine precursors ultimately lead to NAD+ production, they take different routes through your cellular hardware and your body processes each one differently.

These precursors fall into several main categories:

Vitamin B3 derivatives (like niacin and niacinamide)
Advanced compounds (such as NR and NMN)
Amino acids (primarily tryptophan)

Research has shown that supplementing with these precursors can effectively raise NAD+ levels in various tissues, though their efficiency and effects can vary significantly. Some require multiple conversion steps before becoming NAD+, while others follow a more direct path. This distinction becomes particularly important when choosing an NAD supplement, as it can affect both the compound’s potency and how quickly your body can put it to use.

The 9 Known NAD+ Precursors

Each NAD+ precursor represents a unique pathway to cellular energy production, with its own set of advantages and characteristics. These nine molecules form the complete family of established NAD+ precursors.

Nicotinamide Riboside (NR)

First discovered in milk and later identified as a vitamin B3 analog, NR has become a leading NAD+ precursor in longevity research. It follows the NRK pathway, where it’s phosphorylated by NRK1/2 enzymes to form NMN before conversion to NAD+. This efficient pathway, combined with excellent oral bioavailability and ability to cross cell membranes, has made NR very attractive for NAD+ enhancement.

Key Findings:

NR supplementation significantly increased blood NAD+ concentrations in older adults with MCI by approximately 2.6-fold (or 160%) compared to placebo²
NR supplements boost NAD+ levels by an impressive 60% in healthy adults, according to rigorous clinical research³
NR shows an excellent safety profile with no serious side effects even at high doses of 2000mg daily⁴
Early research suggests NR can reduce key inflammatory markers in heart failure patients⁵
NR supplementation appears to increase muscle-repairing satellite cells in human studies⁶

Nicotinamide Mononucleotide (NMN)

Identified as a key NAD+ intermediate in the 1960s, NMN is the direct precursor to NAD+ in the salvage pathway. While initially thought to require conversion to NR before entering cells, the 2019 discovery of the Slc12a8 transporter revealed a direct cellular uptake mechanism. Just one enzymatic step away from becoming NAD+, NMN has shown remarkable promise in aging research.

Key Findings:

NMN supplements are proven safe in humans at doses up to 900mg daily with no serious side effects⁷
Clinical studies consistently show NMN effectively boosts blood NAD+ levels, with higher doses yielding stronger increases⁸
Older adults taking NMN demonstrated measurable improvements in walking distance compared to placebo groups⁹
After 12 weeks of NMN supplementation, elderly men showed meaningful gains in grip strength and walking speed¹⁰
While placebo groups continued aging normally, NMN-treated groups showed no increase in biological age markers over a study period¹¹

Nicotinic Acid (NA) / Niacin

Discovered in 1937 by Conrad Elvehjem, niacin was the first NAD+ precursor used therapeutically. It follows the Preiss-Handler pathway, requiring three enzymatic steps to become NAD+. This classic pathway remains significant today, though the characteristic “niacin flush” – caused by prostaglandin release – can limit its practical use.

Key Findings:

A massive meta-analysis of 119 trials with 35,760 participants showed niacin alone could reduce cardiovascular events¹²
Niacin can slash total cholesterol by 25%, LDL by 15%, triglycerides by 50%, while uniquely boosting good HDL cholesterol by up to 35%¹³
When combined with statins, niacin therapy was proven via MRI to actually reverse arterial plaque buildup¹⁴
A landmark 15-year study found niacin reduced mortality by 11% in heart attack survivors (p=0.0004)¹⁵

Nicotinamide (NAM) / Niacinamide

The most abundant form of vitamin B3 in nature, NAM enters the salvage pathway through conversion to NMN by NAMPT, the rate-limiting enzyme in NAD+ biosynthesis. First isolated in 1935, this flush-free precursor compound is both widely available and well-tolerated.

Key Findings:

Taking 500mg nicotinamide twice daily reduced new skin cancer formation by 23% in high-risk patients¹⁶
Nicotinamide lowered pre-cancerous skin lesions (actinic keratoses) by up to 20% over a 12-month period¹⁷
Nicotinamide helps repair DNA and preserve skin immunity by preventing UV radiation from depleting cellular energy¹⁸
In glaucoma patients, nicotinamide combined with pyruvate showed promising improvements in visual field tests¹⁹
Clinical trials have consistently shown nicotinamide to be safe and well-tolerated, even at high doses²⁰

Tryptophan (Trp)

This essential amino acid was found to contribute to NAD+ production in the early 1950s. Tryptophan follows the de novo pathway, requiring eight enzymatic steps to become NAD+ – the most complex route among all precursors. While not the most efficient path, this discovery highlighted the intricate connection between protein metabolism and NAD+ production.

Key Findings:

Higher tryptophan levels appear critical for nutritional interventions to improve mortality rates in vulnerable patients, with nearly 40% better outcomes in high-tryptophan groups²¹
Tryptophan supplementation at 1+ gram doses may improve sleep quality by boosting melatonin production and sleep duration²²
Higher dietary tryptophan intake significantly reduced depression and anxiety in healthy participants, highlighting its role in mood regulation through serotonin production²³
Research shows tryptophan supplementation can reduce ADHD symptoms and aggressive behavior in children²⁴
Daily intake of ~1 gram tryptophan was linked to a dramatic 60% reduction in migraine risk²⁵

Nicotinic Acid Riboside (NAR)

A lesser-known member of the NAD+ precursor family, Nicotinic Acid Riboside (NAR) follows a distinct metabolic pathway involving nicotinamide riboside kinases (NRK1 and NRK2) before entering the Preiss-Handler pathway. This route to NAD+ production differs from other precursors, suggesting potential unique characteristics. Human studies on NAR remain limited compared to more extensively researched NAD+ precursors like NR and NMN.

Key Findings:

NAR released from cells can be taken up and used as an NAD+ precursor by neighboring cells. Even low micromolar concentrations of NAR were sufficient to maintain viability of cells unable to use other NAD+ precursors
NAR appears to be a more effective NAD+ precursor than nicotinamide riboside (NR) for maintaining cell viability at low concentrations. About 10 times less NAR was required compared to NR to maintain viability of cells treated with an NAD+ biosynthesis inhibitor²⁶

Dihydronicotinamide Riboside (NRH)

One of the newer additions to the NAD+ precursor lineup, NRH has shown impressive efficiency in preclinical studies. This reduced form of NR appears to bypass certain cellular checkpoints, potentially offering a more direct route to NAD+ production. Research is ongoing to fully understand its potential advantages and safety profile.

Key Findings:

NRH is a potent NAD+ booster, increasing cellular NAD+ levels by 2.5-10 fold over control values within just 1 hour of administration²⁷
In obese mice, 7 weeks of NRH supplementation dramatically improved metabolism by enhancing pancreatic function, insulin sensitivity, and fat tissue health through elevated NAD+ and sirtuin activation²⁸
While promising for metabolism, NRH may have an inflammatory dark side – it can trigger inflammation in immune cells called macrophages through specific cellular pathways²⁹

Reduced Nicotinamide Mononucleotide (NMNH)

The most recently identified precursor, NMNH represents a reduced form of NMN that can be directly converted to NADH by NMNAT. This unique pathway, discovered through metabolic studies, potentially offers advantages in NAD+ enhacement, though research is still in early stages.

Key Findings:

NMNH effectively raises NAD+ levels up to 7x in cells, showing enhanced potency compared to traditional NMN supplementation³⁰
While both compounds boost NADH production, NMNH achieves 2.5x baseline levels in cellular studies with particularly strong tissue penetration³¹
NMNH demonstrates unique metabolic effects and growth regulation properties while maintaining a good safety profile at high doses³²

Dihydronicotinic Acid Riboside (NARH)

Discovered alongside other reduced forms of NAD+ precursors, NARH represents another recently identified pathway to NAD+ biosynthesis. This reduced form of NAR enters the Preiss-Handler pathway through a unique mechanism, potentially offering another efficient route to NAD+ production. While research is still emerging, initial studies suggest it may have distinct advantages in certain cellular conditions.

Key Findings:

Researchers discovered NARH, a new NAD+ precursor that works in liver cells, expanding our toolkit for boosting cellular metabolism³³
When combined with NR, NARH creates a powerful synergistic effect that raises NAD+ levels higher than other precursor combinations³⁴

Measure Your NAD+ Levels: From Precursors to Results

Understanding NAD+ precursors is just the first step in optimizing your cellular health. While these compounds offer various pathways to boost NAD+, the key question remains: how do you know if they’re actually working for you?

This is where accurate NAD+ testing becomes essential. The Jinfiniti Intracellular NAD® test measures your actual cellular NAD+ levels, providing precise insights into your current NAD+ status. With a remarkable 3.1% coefficient of variation, this test offers the reliability needed to track changes in your NAD+ levels over time.

Unlike generic wellness metrics, this test measures NAD+ directly within your cells – where it matters most. Each test includes:

A detailed personal report explaining your results
Clear insights into how your levels compare to optimal ranges
Specific recommendations based on your results
Access to expert-led webinar with Dr. Jin-Xiong She, our chief scientist

Whether you’re just starting your NAD+ optimization journey or fine-tuning your existing protocol, knowing your actual NAD+ levels provides the feedback loop needed to make informed decisions about supplementation and lifestyle changes.

Ready to move beyond theory to measurement? Take the first step in understanding your cellular health by measuring your NAD+ levels today.

TEST YOUR NAD LEVELS TODAY

Referenced Sources:

Choosing a High Quality Turmeric Supplement: Buyer’s Guide

Written by Jinfiniti Science on November 19, 2024. Posted in Turmeric/Curcumin. No Comments on Choosing a High Quality Turmeric Supplement: Buyer’s Guide

Your turmeric supplement could be a waste of money.

Harsh? Perhaps. But here’s the truth: not all turmeric supplements are created equal. In fact, many popular brands contain such low-quality ingredients that your body can barely absorb them.

For over 4,000 years, turmeric has been revered in traditional medicine. Today, modern science confirms what ancient healers knew all along – this golden spice packs serious health-promoting power.

But here’s the catch.

As turmeric supplements flood the market, consumers face a bewildering array of choices. Confusing labels. Misleading claims. And prices that range from suspiciously cheap to eye-wateringly expensive.

How do you cut through the noise and find a supplement that actually works?

In this curcumin extract buying guide, you’ll discover:

The common red flags that leave you with an ineffective or, worse, harmful supplement – and how to avoid them.
The four critical factors that separate premium turmeric supplements from worthless pills.
The exact combination of ingredients, dosages, and extraction methods that maximize absorption and effectiveness.
The most bioavailable turmeric supplement on the market.

Health Benefits of Turmeric and Curcumin

Ever wondered why turmeric has a golden color? The same compounds responsible for that vibrant hue also deliver powerful health benefits.

Turmeric root contains a family of active compounds called curcuminoids. The star of the show? Curcumin. This remarkable compound makes up about 2-5% of turmeric and acts as a potent antioxidant and anti-inflammatory agent.

Modern science has extensively studied curcumin’s effects on health. Here’s what the research reveals:

Curcumin targets multiple steps in the inflammatory pathway and matches the effectiveness of some anti-inflammatory drugs – without the harsh side effects¹.
Clinical trials have demonstrated curcumin’s ability to reduce joint tenderness, improve flexibility, decrease inflammatory markers and support cartilage health².
Curcumin can cross the blood-brain barrier, increase BDNF (brain-derived neurotrophic factor)³, support memory and focus, and help maintain cognitive function with age⁴.
Curcumin supports healthy blood pressure⁵, improves blood vessel function⁶, and maintains healthy cholesterol levels⁷.
Curcumin neutralizes harmful free radicals, boosts your body’s own antioxidant enzymes and helps protect cells from oxidative stress⁸.

However, your kitchen turmeric and a high-quality supplement are worlds apart. The powdered turmeric you find on most grocery shelves contains just 2-5% curcumin with poor absorption rates by the body, requiring large amounts for therapeutic effects, making it best suited for adding flavor to food.

What’s more, curcumin is notoriously difficult for your body to absorb. In fact, studies show that plain curcumin gets metabolized and eliminated before it can deliver its benefits.

Hence the importance of choosing turmeric supplements that maximize the absorption of curcumin.

Red Flags When Buying Turmeric Supplements

The truth about turmeric supplements lies in the details. Here are the top warning signs to watch for that signal poor quality and potentially misleading products.

The Mystery of “Proprietary Blends”

When you see “proprietary blend” on a label, proceed with caution. Here’s why:

Manufacturers don’t disclose individual ingredient amounts
You can’t verify if you’re getting therapeutic doses
The first ingredient might be present in meaningful amounts, but the rest could be mere sprinkles
It’s often a tactic to hide low doses of expensive ingredients

What to Do Instead: Look for supplements that clearly list the amount of each ingredient, especially the curcuminoid content.

Suspiciously Low Prices

That bargain-bin turmeric supplement? It’s probably too good to be true. Quality turmeric supplements are expensive to produce because they require:

High-grade raw materials
Standardized extraction processes
Third-party testing
Quality control measures

If a month’s supply costs less than $20, question what corners were cut to achieve that price.

Industry Insight: High-quality turmeric extract with 95% curcuminoids is expensive to produce. When you factor in other active ingredients and production costs, extremely low prices simply don’t add up.

Missing or Vague Standardization Information

Quality supplements proudly display their standardization percentages. Red flags include:

No mention of curcuminoid percentage
Unclear extract ratios
Missing potency information
Vague terms like “high-strength” without specifics

What to Look For: Clear statements like “standardized to 95% curcuminoids” or “contains 1000mg of turmeric extract (95% curcuminoids).”

The Filler Trap

Check the “Other Ingredients” section carefully. Avoid supplements loaded with:

Artificial colors
Chemical preservatives
Unnecessary binding agents
Cheap bulking agents like maltodextrin
Silicon dioxide in large amounts

Best Practice: Look for products with minimal necessary ingredients and vegetable-based capsules.

What to Look For When Choosing a Turmeric Supplement

Choosing the right curcumin supplement doesn’t have to be complicated. Armed with the right knowledge, you can quickly identify high-quality products that deliver real results.

Here are the three essential factors that separate premium supplements from ineffective ones.

Curcuminoid Content

A high-quality turmeric supplement should contain extract standardized to 95% curcuminoids, with the amount clearly stated on the label. Research shows this concentration provides the most powerful anti-inflammatory and antioxidant benefits.

Bioavailability Enhancers

Even the highest-quality curcumin is useless if your body can’t absorb it. That’s why leading supplements include bioavailability enhancers like black pepper extract (standardized to 95% piperine), which can increase absorption by up to 2000%⁹.

Dosage Considerations

Research indicates that the sweet spot for turmeric supplementation is 1000-1500mg of standardized extract per day, typically divided into 1-2 doses. More isn’t necessarily better – studies show that doses above 2000mg per day don’t provide additional benefits and may increase the risk of mild side effects.

A high-quality turmeric supplement should check all these boxes:

✓ 95% standardized curcuminoid extract

✓ Bioavailability enhancers included

✓ 1000-1500mg daily dose

✓ Clear labeling of all ingredients

The Best Turmeric Supplement: Extra Strength Turmeric+ Formula

After examining countless turmeric supplements on the market, we found most fall short in either potency, absorption, or synergistic support. That’s why we developed our Extra Strength Turmeric+ curcumin supplement, a premium formula that combines clinical-grade turmeric with proven synergistic ingredients.

Each daily serving of Extra Strength Turmeric+ delivers:

Maximum-Strength Turmeric Extract (1000mg)

Standardized to 95% curcuminoids
Highest purity available
Clinically-validated dosage
Premium extraction process

Strategic Absorption Enhancement

Black Pepper Extract (30mg, standardized to 95% piperine) ensures maximum bioavailability. Studies show this critical addition can increase curcumin absorption by up to 2000%.

Synergistic Anti-Inflammatory Support

Our formula amplifies turmeric’s benefits with a targeted blend of complementary ingredients:

Boswellia Extract (200mg, >65% Boswellic Acid)

Works through different inflammatory pathways than curcumin
Enhances joint comfort and mobility
Provides sustained anti-inflammatory support

Ginger Root Extract (4:1) (200mg, 10% Gingerols)

Complements turmeric’s anti-inflammatory effects
Supports digestive health
Enhances overall absorption

Quercetin (70mg, 95% Purity)

Powerful antioxidant support
Enhances the effects of other botanicals
Supports cellular health

Why Our Formula Works Better

Most turmeric supplements stop at basic ingredients. Extra Strength Turmeric+ takes a different approach:

Multiple Action Pathways: Our ingredients work through different mechanisms, providing comprehensive inflammatory support.
Enhanced Absorption: Each compound is delivered in its most bioavailable form, ensuring maximum uptake.
Optimal Dosing: Every ingredient is included at its clinically-validated dose – no cutting corners.
Quality Assurance: Produced at a GMP-certified manufacturing facility, ensuring quality, safety and consistency.

DISCOVER TURMERIC+

Turmeric Extract FAQs

What is the Bioavailability of Curcumin?

Raw curcumin has naturally low bioavailability (around 3-8%), meaning only a small portion gets absorbed into your bloodstream when consumed alone.

Does Black Pepper Extract Increase Turmeric Bioavailability?

Piperine, the active compound in black pepper, can enhance curcumin absorption by up to 2000% by inhibiting liver enzymes that would normally break it down.

What Form of Curcumin is Best?

Curcumin formulated with black pepper extract (BioPerine) is considered the most effective form, as it significantly improves absorption compared to standard supplements.

When is the Best Time to Take Curcumin?

For optimal absorption, take curcumin supplements with a meal containing healthy fats, as curcumin is fat-soluble and needs dietary fat to be properly absorbed.

How Does Curcumin Help with Inflammation?

Curcumin works by blocking key inflammatory molecules like NF-kB and COX-2, while also acting as a powerful antioxidant that neutralizes free radicals in the body.

Referenced Sources:

What is NAD+ and What Does It Do For Cellular Health?

Written by Jinfiniti Science on November 15, 2024. Posted in NAD, NAD+, Premature Aging. No Comments on What is NAD+ and What Does It Do For Cellular Health?

In the world of health and longevity, there’s one molecule that’s been making waves for its important role in cellular health: NAD+. Short for Nicotinamide Adenine Dinucleotide, NAD+ is a coenzyme present in every cell of our body, and it’s often called a “helper molecule” for good reason.

It helps in converting the food we eat into energy and supports vital functions like repairing damaged DNA. However, as we age, our natural NAD+ levels start to decline, which can affect everything from metabolism and energy to our cells’ ability to repair themselves.

This drop in NAD+ is linked to a range of age-related issues, including lower energy, slower metabolism, and an increased risk of chronic diseases.

So, what exactly does NAD+ do for our cells, and why is it essential for staying healthy as we get older?

In this article, we discuss…

The critical role of NAD+ in maintaining cellular health
What happens when your NAD+ takes a dive (and why it matters)
Effective ways to supercharge your NAD+ levels for peak performance and longevity

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a molecule that drives hundreds of critical metabolic processes inside our cells, acting as a cellular energy shuttle. First discovered in 1906 by scientists studying fermentation in yeast, NAD+ isn’t just another biochemical compound.

It’s a direct participant in cellular energy production, moving electrons and triggering repair signals. When you consume food, NAD+ helps break down nutrients and convert them into usable cellular energy.

Picture your cells as intricate machines. NAD+ serves as both the fuel line and the maintenance crew, making sure everything operates as efficiently as possible. It shuttles electrons during metabolic reactions and alerts cellular systems when something needs fixing.

Here’s where things get interesting – and a bit frustrating. As we age, our NAD+ levels take a nosedive, typically dropping by half between our 20s and 80s. It’s one of biology’s cruel jokes: just when we need cellular efficiency the most, our NAD+ supply starts dwindling.

The science behind this decline is pretty fascinating. Your cells face a double setback: they start producing less NAD+ while simultaneously using more of it to repair accumulated damage. It’s like trying to feed a growing family with a garden that keeps shrinking.

Thankfully, your body has multiple ways to make NAD+. It can be created from tryptophan (yes, the amino acid in turkey), from vitamin B3, or by recycling existing NAD+ molecules. This versatility has sparked intense research interest, with scientists discovering that NAD+ is involved in over 500 different cellular reactions – quite a resume for one tiny molecule!

This has led to exciting developments in aging research, including promising approaches using precursor molecules like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Understanding how to maintain healthy NAD+ levels through various pathways could be one of the keys to healthier aging.

The Discovery of NAD+

The story of NAD+ began in a humble laboratory in 1906, when two British biochemists made a puzzling observation while studying yeast. Sir Arthur Harden and William John Young noticed something extraordinary: when they added boiled yeast extract to fresh yeast, the fermentation process unexpectedly accelerated. The mysterious compound they had stumbled upon, which they dubbed “cozymase,” would later become known as NAD+ (Nicotinamide Adenine Dinucleotide).

The scientific community quickly recognized the magnitude of this finding, and researchers around the world began unraveling the secrets of the molecule. Hans von Euler-Chelpin made significant strides in the 1920s and 1930s, mapping out NAD+’s chemical structure and identifying its key components – sugar, adenine, and phosphate. His groundbreaking work, along with Harden’s initial discovery, earned them both the 1929 Nobel Prize in Chemistry. The breakthrough continued when Otto Heinrich Warburg discovered in 1936 that NAD+ contained a special pyridine ring that could transfer hydrogen atoms, explaining how it helped cells transform nutrients into energy.

As research techniques improved, scientists gradually mapped out NAD+’s complete structure and began to understand its true importance in the cell. What started as a curious observation about yeast fermentation led to one of biochemistry’s most crucial discoveries. NAD+ turned out to be essential not just for fermentation, but for DNA repair, gene expression, and cellular communication – making it a fundamental molecule for life itself.

What’s the Purpose of NAD+ in the Human Body?

NAD+ switches between two states: NAD+ (oxidized) and NADH (reduced). This molecular switch enables core cell operations like energy production, DNA maintenance, and cell communication.

As an electron carrier, NAD+ moves electrons during metabolism. When reduced to NADH, it delivers electrons to the transport chain that generates ATP – the basic fuel cells need. The continuous conversion between NAD+ and NADH maintains energy flow through major pathways like glycolysis and the citric acid cycle¹.

NAD+ supplies key materials to DNA repair enzymes called PARPs². When NAD+ runs low, DNA damage builds up, which can raise the risk of cancer. Research shows that higher NAD+ levels strengthen DNA protection³.

Through its influence on sirtuins, NAD+ regulates how genes turn on and off by modifying chromatin proteins.⁴ This shapes aging patterns and metabolic function.

NAD+ also helps create signaling molecules like cyclic ADP-ribose (cADPR) that coordinate calcium movement and other essential cell activities.

Put simply, NAD+ supports energy production, DNA repair, gene regulation, and cellular signaling. Maintaining healthy levels of NAD+ is instrumental for cellular health and resilience, helping us achieve better health and longevity.

What Happens If You Have Low NAD+?

Since NAD+ is involved in processes like energy production, DNA repair, and cellular signaling, low levels can disrupt these vital functions and lead to symptoms of NAD+ deficiency, as well as a range of health issues affecting metabolism, brain function, and heart health.

When it comes to metabolic disorders, declining NAD+ levels are linked to issues with glucose and lipid metabolism. This can result in insulin resistance⁵, a major factor in metabolic syndrome—a condition characterized by obesity, high blood pressure, and abnormal cholesterol levels. Research published in Frontiers in Endocrinology found that people with lower NAD+ levels had a higher prevalence of metabolic diseases, including hypertension and diabetes⁶.

NAD+ also supports brain health by maintaining the energy production and DNA repair mechanisms that support neurons. In conditions like Alzheimer’s and Parkinson’s diseases, NAD+ levels are often lower, which may accelerate neurodegeneration⁷.

Low NAD+ levels can also negatively impact heart health. The heart requires a lot of energy to function, and NAD+ is essential for maintaining efficient energy production.

Reduced NAD+ levels can impair mitochondrial function, leading to lower ATP production and a higher risk of heart failure. This has been supported by a study published in the Frontiers in Physiology, where researchers discovered that NAD+ metabolism disruptions are closely linked to cardiovascular conditions, such as ischemic heart disease and heart failure⁸.

Ultimately, low NAD+ levels can have wide-reaching effects on metabolism, brain function, and cardiovascular health. But through optimizing your NAD levels, you can prevent or manage these issues for better health outcomes.

Benefits of NAD+ for Cellular Health

Beyond its all-important role in energy production, NAD+ offers a remarkable array of benefits for cellular health that make it indispensable for optimal functioning.

One of its most significant advantages is its ability to activate enzymes called sirtuins, which act as cellular stress sensors⁹. When activated by NAD+, these sirtuins help cells adapt to various forms of stress, from metabolic fluctuations to environmental challenges, essentially functioning as cellular guardians that promote resilience and longevity.

The health benefits of NAD+ also include maintaining robust cellular communication networks, particularly through a process called ADP-ribosylation. This process helps cells respond appropriately to damage or stress signals, ensuring they can coordinate their responses effectively.

We can think of NAD+ as a cellular emergency response system. When one part of the cell detects a problem, NAD dependent signaling helps mobilize the appropriate repair mechanisms, maintaining cellular health and preventing potential dysfunction.

In essence, the importance of NAD cannot be overstated for sustaining cellular vitality, promoting healthy aging, and improving our overall quality of life as we grow older. It’s not just about energy, but about thriving as you age.

Can NAD+ Truly Slow Aging?

If you’re hoping to feel younger and stay healthy as you age, boosting your NAD+ levels might be the answer. NAD+ has become a buzzword in anti-aging research, with growing evidence suggesting it can help slow down the aging process by improving cellular health.

For example, research published in Frontiers in Aging found that supplementing with NMN (a precursor to NAD+) can improve energy levels and insulin sensitivity, both crucial for healthy aging¹⁰.

In this 60-day study, participants took 300 mg of NMN daily, leading to an impressive 38% increase in NAD+/NADH levels by day 60. Meanwhile, those on a placebo saw minimal changes. The NMN group also reported better quality of life and stable insulin sensitivity, while the placebo group experienced declines. This shows that NMN can effectively boost NAD+ levels, improve energy, and support better metabolic health.

Another study in Nature Communications looked at nicotinamide riboside (NR), another NAD+ booster. Participants took 500 mg twice daily for six weeks. The results showed a significant increase in NAD+ levels, improving several metabolic health markers. Although major changes like blood pressure were not observed, the rise in NAD+ suggests that it could help enhance overall cellular function¹¹.

A long-term study published in Scientific Reports explored how NMN impacts cardiovascular health in older adults¹². For 12 weeks, participants took 250 mg of NMN daily. While their blood pressure didn’t change much, there was a positive trend toward reducing arterial stiffness, a sign of better cardiovascular health. This suggests NMN might help support heart health as we get older.

These findings suggest that keeping your NAD+ levels up could help slow the progress of age-related diseases. It not only helps boost energy and improve metabolism but also supports healthy blood sugar levels and may even protect your heart.

Replenishing NAD+ Levels in Your Body

Supporting your NAD+ levels helps maintain cell health and can slow down signs of aging. While lifestyle changes like regular exercise, calorie restriction, and consuming foods high in NAD precursors can support the body’s NAD+ production, their impact often diminishes as we get older.

Opting for a more targeted approach—combining NAD+ testing with strategic supplementation of NAD precursors—can be much more effective to naturally increase NAD levels.

The truth is, there isn’t a one-size-fits-all approach to optimizing NAD+ levels, so the first step is to assess where your levels currently stand — are they lower than they should be, at baseline, or optimized?

Knowing this will help you determine the right dosage of NAD+ supplementation for your needs.

An Intracellular NAD+ test serves as an effective diagnostic tool in this context. Testing your NAD+ levels is the most effective way to figure out the optimal dosage for you.

Ideally, you should measure both at baseline and after supplementation. At a minimum, testing after supplementation is essential, as the same dosage may work differently for different people—it could be optimal, ineffective, or even toxic. An NAD+ test provides you with actionable data to help you optimize both your NAD+ levels and your overall health.

If you’re already taking NAD+ supplements, using NAD+ IV infusions, injections, or patches, it’s crucial to test your levels to ensure these products are actually working. Many products on the market don’t deliver the desired results, or they don’t work as effectively as they claim.

For optimal NAD+ enhancement, our Vitality ↑® NAD+ Booster delivers a clinically validated formulation that combines key NAD precursor NMN with Creatine monohydrate, D-ribose, and Nicotinamide. This synergistic blend demonstrates superior efficacy in elevating cellular NAD+ levels while promoting comprehensive cellular regeneration.

In fact, Vitality ↑® NAD+ Booster outperforms many other NAD+ precursors on the market. Almost all users with optimized NAD+ levels report noticeable improvements in their health and performance, making it an excellent choice for anyone looking to boost their NAD+ levels.

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Future Directions for NAD+ Research

The future of NAD+ research is brighter than ever, with two exciting areas taking center stage: personalized NAD+ therapies and advanced monitoring techniques.

With personalized therapies, you can now customize NAD+ interventions based on your unique metabolic profile and health needs. This means you’ll receive the optimal dosage and type of NAD+ precursor tailored specifically to you, boosting the effectiveness of supplementation and enhancing cellular health.

The potential? Slowing age-related decline and improving overall vitality.

On the other hand, the development of real-time NAD+ monitoring tools is helping us better understand and manage cellular metabolism. Using genetically encoded fluorescent sensors, researchers can now track NAD+ levels dynamically within cells. This provides deeper insights into metabolic states and how cells respond to various stimuli.

At Jinfiniti, we’re proud to be at the forefront of this research with our cutting-edge Intracellular NAD test and Vitality ↑® NAD+ Booster supplement.

The Intracellular NAD test allows you to accurately measure your NAD+ levels, offering valuable insights into your metabolic health and identifying specific supplementation needs. This personalized testing approach ensures that you can effectively optimize your NAD+ levels, boosting cellular function and vitality.

Our Vitality ↑® NAD+ Booster supplement supports this process by providing key precursors to help your body naturally synthesize more NAD+.

By combining advanced testing with the Intracellular NAD test and targeted supplementation like Vitality ↑® NAD+ Booster, we’re taking a comprehensive approach to enhance cellular health and longevity. This empowers you to take control of your health and represents a major step forward in understanding how NAD+ can improve well-being as we age.

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Referenced Sources:

NAD Levels by Age Group: What’s Considered Normal?

Written by Jinfiniti Science on November 12, 2024. Posted in NAD, NAD+, NAD+ Precursors, Premature Aging. No Comments on NAD Levels by Age Group: What’s Considered Normal?

Your body is a vast metropolis, with billions of cells working around the clock to keep you alive and thriving. At the heart of this cellular city lies NAD+ ( short for nicotinamide adenine dinucleotide) – the power currency that keeps your cellular economy from entering a recession.

Just as a city needs electricity to function, every cell in your body needs NAD+ to convert food into energy, repair damaged DNA, and regulate your biological clock. This coenzyme helps your cells perform over 500 different biochemical reactions, making it one of the most important players in healthy aging and overall wellness.

Unfortunately, our bodies’ levels of NAD naturally decline as we age, dropping by up to 50% between our 20s and 80s. This decline is linked to many of the telltale signs of aging, from decreased energy levels to slower recovery after exercise. Understanding what’s “normal” for NAD+ levels at different ages can help us better grasp why we feel the way we do as time passes, and potentially, what we can do about it.

In this article, you’ll discover:

How NAD+ acts as your cells’ power currency, orchestrating over 500 vital biological processes that keep you healthy and energized
The natural timeline of NAD+ decline through aging, from peak levels in your 20s to significant decreases by age 50
Why men and women experience different patterns of NAD+ decline, and how hormones play a role
Science-backed strategies for maintaining optimal NAD+ levels, including why lifestyle changes alone aren’t enough to counter age-related decline

NAD+ and Aging

Middle-aged couple holding hands by the lake

Your body’s NAD+ levels follow a predictable pattern throughout life – and unfortunately, it’s a downward trend. Research shows that NAD+ levels peak during our early 20s and then begin a steady decline, with most people experiencing a 40-50% drop by age 50. But why does this happen? The answer lies in a perfect storm of biological events.

As we age, certain enzymes, particularly PARPs and CD38, become increasingly active and hungry for NAD+¹. PARPs ramp up their activity to repair age-related DNA damage, while CD38 levels rise as part of our body’s inflammatory response to aging. It’s like having more bills to pay but with the same paycheck – something has to give.

At the same time, our body’s ability to produce new NAD+ takes a hit. The molecular building blocks (or precursors) that we use to make NAD+ become less available, and the cellular machinery (biosynthetic enzymes) that assembles these pieces slows down². It’s similar to a factory facing both parts shortages and aging equipment – production inevitably drops.

This decline in NAD+ levels has real consequences for how we age. When cells can’t maintain healthy NAD+ levels, their energy production falters, DNA repair slows down, and cellular stress responses become sluggish. These changes contribute to many hallmarks of aging, from decreased muscle strength and slower wound healing to increased susceptibility to age-related diseases like cardiovascular problems and neurodegenerative conditions.

The Timeline of NAD+ Decline

Visual gif chart of NAD+ levels decline by age group

Infancy & Childhood (0-12 years)

NAD+ levels are naturally high and stable
Peak production supports rapid growth and development

Adolescence & Young Adulthood (13-30 years)

Levels reach their lifetime peak in early 20s
Optimal cellular energy and repair functions
Gradual decline begins around age 25

Middle Age (31-60 years)

Sharp decline begins
Most dramatic drop occurs between 40-49 years³
Average person loses 40-50% of young adult levels by age 50

Senior Years (60+ years)

Levels can drop to 1-10% of youthful amounts
By age 80, typical levels are less than half those at age 40
Continued gradual decline without intervention

What are Normal NAD Levels by Age Group?

Inside our cells, NAD concentrations can range from as low as 10 μM to as high as 1000 μM⁴. To put this in perspective, imagine filling a drop of water with different amounts of NAD – some cells maintain just a trace amount, while others keep a abundant supply, depending on their specific energy needs. When measured in tissue samples, researchers have found total NAD concentrations between 0.3 and 0.4 μmol/g.

Our research indicates that intracellular NAD+ concentrations of 40 µM or higher are associated with optimal cellular function, regardless of age. At 40 μM and above, many NAD-dependent enzymes, including some sirtuins and PARPs, can function effectively.

Measuring Your NAD Levels

Clinical evidence suggests that suboptimal NAD levels may contribute to various health challenges – from chronic fatigue and sleep disturbances to cognitive decline and metabolic disorders.

Modern methods like Jinfiniti’s Intracellular NAD Test now allow for precise measurement of cellular NAD concentrations through convenient at-home collection, enabling individuals to assess their personal NAD status and work to optimize their levels and address NAD deficiency symptoms through targeted interventions.

TEST YOUR NAD LEVELS TODAY

The Gender Gap in Age-Specific NAD+ Levels

Older couple on bench staring into the mountains

Studies have consistently shown that men tend to have higher baseline levels of whole blood NAD+ compared to women. In one large-scale study of over 1,500 participants, the average NAD+ level in men was 34.5 μmol/L, while women averaged 31.3 μmol/L⁵.

However, the way NAD+ levels change with age differs significantly between the sexes:

In men, NAD+ levels tend to decline gradually with age, with a more pronounced drop observed after age 60
Women, on the other hand, show a more complex pattern. Their NAD+ levels fluctuate across age groups without a clear downward trend

The distinct NAD+ profiles between men and women suggest that hormones play a role in regulating NAD+ metabolism. Researchers speculate that female sex hormones, particularly estrogen, may help maintain NAD+ levels throughout a woman’s life. This hypothesis is supported by observations in post-menopausal women, whose NAD+ patterns begin to resemble those of men.

The gender gap in NAD+ levels and their age-related changes may have far-reaching implications for how men and women age:

Higher NAD+ levels in men might provide them with a metabolic advantage in youth, but the steeper decline with age could contribute to accelerated aging in some aspects.
The more stable NAD+ levels in women could potentially offer some protection against certain age-related diseases, though more research is needed to confirm this.
The effectiveness of NAD+ boosting supplements or therapies may differ between men and women, necessitating gender-specific approaches to anti-aging treatments⁶.

Strategies for Increasing NAD+ Levels as You Age

While many people seek to naturally increase NAD levels through lifestyle modifications like exercise, intermittent fasting, and consuming NAD-rich foods, research shows these methods alone can’t fully counter age-related NAD+ decline. It’s like trying to fill a leaking bucket – as we age, our cells’ increasing demand for NAD+ outpaces what we can restore through lifestyle changes alone.

A more comprehensive approach involves strategic supplementation with NAD boosters that target the root cause of age-related NAD+ decline. The key lies in providing your body with the right precursors in the right combinations to optimize NAD+ production at the cellular level.

Recent clinical research has revealed that a synergistic approach yields better results than single-compound solutions. This breakthrough understanding led to the development of Vitality ↑® NAD+ Booster, a scientifically formulated combination of NMN, Creatine monohydrate, D-Ribose, and Nicotinamide. Each component plays a crucial role:

NMN serves as a direct NAD+ precursor
Creatine monohydrate supports energy metabolism
D-Ribose enhances cellular energy production
Nicotinamide helps regulate NAD+ consumption

What sets this formulation apart is its extensive validation – from clinical studies to real-world testing in hundreds of clinics. The data speaks for itself: approximately 85% of users achieve optimized NAD+ levels, as confirmed through clinical testing. This high success rate demonstrates that while aging’s effects on NAD+ levels are inevitable, they’re not irreversible.

Think of maintaining healthy NAD+ levels as a long-term investment in your cellular health. While lifestyle factors provide the foundation, targeted supplementation with clinically validated NAD boosters offers the most reliable way to maintain optimal NAD+ levels as you age. The key is choosing a solution backed by both scientific research and real-world results.

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Referenced Sources

Can NAD Supplements Help You Lose Weight?

Written by Jinfiniti Science on November 9, 2024. Posted in Glucose, NAD, NAD+, NAD+ Precursors. No Comments on Can NAD Supplements Help You Lose Weight?

Losing weight can feel like an uphill battle, especially when you’re dealing with stubborn fat, a sluggish metabolism, and constant fatigue. If you’ve tried everything from restrictive diets to intense exercise regimens, yet still struggle to shed those extra pounds, the solution may lie in a vital compound called NAD+.

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that plays a crucial role in cellular energy production, fueling a wide range of bodily functions, including metabolism. However, as we age, our natural NAD+ levels begin to decline, which can impact our ability to lose weight and maintain a healthy physique.

Fortunately, growing research suggests that supplementing with NAD+ precursors may hold the key to revitalizing your weight loss efforts. By boosting your NAD+ levels, you can potentially experience increased energy, enhanced fat-burning capabilities, and a faster, more efficient metabolism – all of which can contribute to successful and sustainable weight management.

So, can NAD supplements help you achieve your weight loss goals?

In this article, you’ll discover:

How NAD+ can help speed up your metabolism and burn fat more effectively.
The weight loss roadblocks NAD+ can help you break through for lasting results.
How NAD+ supplements can make managing your weight and metabolism easier and more sustainable.

NAD+ and Metabolic Function

NAD+ is a crucial molecule that powers our cells’ energy production. As a coenzyme, it supports several metabolic processes, including glycolysis, the citric acid cycle, and oxidative phosphorylation¹.

During glycolysis, NAD+ helps convert glucose (a type of sugar) into pyruvate, releasing energy in the process². This pyruvate then enters the next stages of energy production, where NAD+ helps extract even more energy from it.

For glycolysis to keep functioning, NADH (the reduced form of NAD+) must convert back into NAD+. This recycling ensures the process continues without a buildup of substances, supporting consistent energy production for all cellular activities, including metabolism.

In the citric acid cycle, NAD+ helps break down nutrients to produce high-energy electron carriers³. As nutrients are processed, NAD+ collects these high-energy electrons, which act like power boosts for our cells.

These electrons are then sent to the electron transport chain during oxidative phosphorylation, where their energy is used to produce ATP, the main energy currency of our body. This process is crucial for boosting metabolism and burning fat to manage weight effectively.

However, as we age, our bodies naturally see a decline in NAD+ levels. A 2022 study published in the journal Experimental Gerontology found that these levels can decrease by more than 50% from young adulthood to older ages⁴.

This decrease is alarming because low NAD levels can signal an energy deficiency⁵, making it harder for cells to metabolize nutrients effectively. Maintaining the right balance of NAD+ is crucial for optimal metabolic function and supporting healthy weight management.

With less NAD+, our energy production slows down, making it harder to burn calories efficiently. This slowdown can lead to weight gain or difficulty losing weight, contributing to those frustrating plateaus many experience in their fitness journeys.

NAD+ is also involved in regulating sirtuins⁶, enzymes that help manage fat metabolism and insulin sensitivity. As NAD+ levels fall, sirtuin activity can decrease, further hampering the body’s ability to regulate weight.

Moreover, NAD+ helps regulate autophagy, the process by which the body cleans out damaged cells. As we age, autophagy slows down⁷, and since NAD+ is needed for this to happen, lower levels can lead to a buildup of damaged cells. This accumulation can mess with your metabolism and contribute to weight gain.

NAD+ and Fat Tissues

NAD+ actively supports the functions of our fat tissues, specifically in white adipose tissue (WAT) and brown adipose tissue (BAT), which together enhance energy balance and optimize metabolic health.

WAT acts as an endocrine organ that secretes hormones like leptin, which regulate appetite and metabolism⁸. NAD+ influences the production and function of this hormone. For example, adequate NAD+ levels may improve leptin receptor sensitivity, which helps regulate appetite and reduce overeating.

Normal NAD+ levels are also necessary for the cells in WAT to respond well to insulin⁹, allowing glucose to be used for energy instead of being stored as fat. Low NAD+ levels can impair this process, contributing to insulin resistance and excess fat storage.

On the other hand, brown adipose tissue (BAT) contains a high concentration of mitochondria and burns energy to produce heat through thermogenesis¹⁰. This process is regulated by the protein UCP1 (uncoupling protein 1), which releases energy as heat instead of storing it.

NAD+ fuels BAT’s high metabolic rate and promotes the breakdown of stored fat for heat production. Activating BAT through NAD+ boosts thermogenesis, increasing overall energy expenditure¹¹, which can help with body weight management.

Another important role of NAD+ in fat tissues is its involvement in the “browning” of white fat. NAD+ helps trigger this transformation, where white fat cells convert into a more metabolically active form, similar to brown fat cells. As a result, these browned fat cells gain a higher mitochondrial density and can burn fat for energy.

A study published in Redox Biology shows that browning boosts fat’s metabolic activity¹², turning WAT from a passive storage site into an active fat-burning depot. This process can potentially reduce fat accumulation, especially in areas prone to stubborn fat storage.

The Science Behind NAD+ and Weight Loss

NAD+ is vital for cellular energy production. It helps convert glucose and fatty acids into usable energy within the mitochondria¹³, the powerhouses of cells. This energy drives everything from muscle function to body temperature regulation, making efficient energy conversion essential for managing weight.

The body’s metabolic flexibility, or the ability switch between burning fats and carbohydrates for fuel, is improved by NAD+, which supports energy conversion and activates metabolic enzymes.

While NAD+ helps support metabolic processes and energy expenditure, optimal levels are linked to healthier body composition¹⁴. Higher NAD+ levels are associated with better preservation of lean muscle mass, while low levels can contribute to fat accumulation.

Through its effects on cellular health and metabolic rate, NAD+ can help maintain a favorable balance between muscle and fat in the body, leading to a leaner physique over time.

Indeed, research shows that NAD+ may support weight management and improved body composition¹⁵. Healthy NAD+ levels also boost mitochondrial function and fat metabolism, which may contribute to weight management and metabolic health in the long run.

NAD+ also affects adiponectin, a hormone produced by fat cells that regulates glucose levels and breaks down fatty acids. Optimal NAD+ levels support adiponectin production¹⁶, which in turn improves insulin sensitivity and reduces inflammation.

This can help the body manage blood sugar better and reduce fat storage, both key factors in healthy weight management. So, while NAD+ itself might not directly burn fat, its role in reducing inflammation and supporting metabolic processes indirectly supports weight control and helps prevent metabolic dysfunctions that often accompany obesity.

Clinical Research on NAD for Weight Loss

Emerging research shows how NAD+ promotes weight loss and fat metabolism. While NAD+ has long been known as crucial for energy production, new studies reveal its potential to enhance the body’s ability to burn fat.

A study published in Frontiers in Nutrition involving 5,144 participants found that taking NAD+ precursors can lower Body Mass Index (BMI) and increase adiponectin levels.¹⁷ Specifically, people who took NAD+ supplements experienced a small yet significant reduction in BMI.

Another study published in the Journal of Nutritional Biochemistry looked at how nicotinamide (NAM) affects obesity in mice. The researchers found that NAM supplementation reduced fat mass and improved glucose tolerance¹⁸. It also increased mitochondrial proteins in fat tissue, suggesting that NAM boosts mitochondrial function, which is important for burning fat.

Moreover, NAM raised NAD+ levels by over 30% and enhanced glutathione production, supporting better metabolic function and easier weight management. Overall, NAM seems to reprogram how fat cells work to fight obesity-related issues.

Another study also found that NAD+ precursors can help with weight loss by improving insulin sensitivity and enhancing metabolic function. By boosting NAD levels, these precursors may help regulate energy expenditure and fat metabolism, making it easier for the body to burn fat.¹⁹

Overall, optimized NAD can help support better metabolic health and weight management and reduce obesity-related complications.

NAD+ Precursors and Their Weight Loss Effects

Of all the known NAD boosters, two of the most well-known are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

A 2021 study found that NR supplementation was associated with reduced weight gain and preservation of muscle mass. NR also aided in weight reduction and increased lean mass relative to body fat. In rats on calorie restriction, NR reduced inflammation in the hypothalamus²⁰, a brain region important for weight control.

These findings suggest that NR, especially when combined with calorie restriction, could aid in weight management by promoting fat loss without sacrificing muscle, as well as by reducing certain inflammatory markers.

NMN, another direct precursor of NAD+, also shows promising effects on body composition and metabolism. A study published in the IUBMB Life journal demonstrated that NMN helped reduce fat mass, preserved lean muscle, and improved glucose tolerance²¹.

The researchers also found that NMN lowers blood lipid levels and reduces liver fat, mitigating inflammation in fat tissue and addressing fatty liver issues often seen with obesity. NMN appears to support a shift toward a healthier body profile.

On top of that, NMN’s ability to reduce fat tissue inflammation, improve insulin sensitivity, and boost insulin secretion could make it a helpful tool for balancing blood sugar and supporting a leaner body—both important for managing weight and metabolic health.

While NR and NMN are among the most studied NAD+ precursors, two other forms of vitamin B3, niacin and nicotinamide, also contribute to NAD+ production and deliver their own unique benefits to help with weight management and overall metabolic function.

Niacin assists in the body’s fat and sugar processing, supporting cellular health, which is essential for weight control. At higher doses, niacin can also improve blood triglyceride levels, helping prevent fat accumulation and promoting a balanced body composition.

In fact, a study published in Cell Metabolism found that niacin effectively boosts NAD+ levels in adults. At doses up to 1,000 mg daily, blood NAD+ levels increased up to eightfold, and participants experienced a significant liver fat reduction of up to 50%.²²

Nicotinamide, on the other hand, shows promise in metabolic function improvement through reducing fat mass and increasing lean muscle. In 2021, a study found that Nicotinamide improved weight management in mice²³. When given to them, Nicotinamide increased how much energy they burned and changed their body fat composition. The mice ended up with more brown and beige fat, which is good for burning calories.

In addition to well-known NAD+ precursors, D-ribose is another supplement worth trying. This naturally occurring sugar doesn’t directly increase NAD+ levels like the others, but it helps the body produce ATP, which in turn supports NAD+ production. This makes D-ribose another useful tool for boosting energy and metabolism.

At the end of the day, taking a holistic approach when using NAD precursors to improve metabolic function for weight loss is key to maximizing results. Jinfiniti’s Vitality ↑® NAD+ Booster exemplifies this by combining four synergistic ingredients: NMN, Creatine monohydrate, D-ribose, and nicotinamide.

This unique formulation supports cellular metabolism and energy to help your body lose weight efficiently. This clinically validated formulation ensures you’re not just supplementing but revitalizing your entire well-being by increasing NAD at the cellular level.

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Does NAD IV Therapy Work for Weight Loss?

NAD IV therapy has become a buzzword for those seeking weight loss, but it’s important to manage expectations. While NAD therapy boosts extracellular NAD levels, which can help with energy and metabolism, it shouldn’t be the sole strategy for shedding pounds.

When considering NAD supplements versus IV therapy, it’s important to understand their differences. NAD precursor supplements are easy to take regularly and support long-term cellular health, offering a gradual boost to NAD+ levels and metabolism over time. This makes them a good choice for steady, ongoing weight management.

In contrast, NAD IV treatment provides a higher, more immediate dose of NAD+, delivering quicker effects. While it can temporarily increase energy levels and metabolism, the impact on long-term fat loss or significant weight reduction may be limited without accompanying lifestyle changes.

Moreover, NAD IV therapy can be costly, and some people experience side effects like headaches, nausea, or dizziness. These effects are generally temporary but it’s important to be aware of them before undergoing treatment.

So, if you’re considering NAD injections for weight loss, it’s important to remember that it should be part of a broader strategy that includes a balanced diet and regular exercise. Ultimately, the choice depends on your personal health goals and budget.

Potential Side Effects of NAD Supplementation

Current evidence points to NAD+ supplements being generally safe and well-tolerated, with some important caveats: long-term effects of high doses aren’t fully understood yet, and the supplement market’s limited regulation poses inherent risks.

Variable product quality and potential impurities remain ongoing concerns, making it important to opt for manufacturers that demonstrate their commitment to quality through independent testing.

How to Increase NAD Levels for Weight Loss

Increasing your NAD levels is a powerful way to support metabolism and make weight management easier, and there are a few simple steps to get started.

First up: diet. Choosing niacin-rich foods like vegetables, whole grains, and lean proteins can give your body the building blocks it needs to produce more NAD+. Even adding fermented foods, like kimchi and sauerkraut, can help out with a small NAD+ boost while benefiting gut health.

Next, staying active is key. Exercise—especially high-intensity and endurance workouts—naturally supports NAD production in your cells. Whether it’s a brisk walk, a run, or a strength session, regular movement keeps your energy high and your metabolism on point.

Making small lifestyle tweaks also goes a long way. Practicing intermittent fasting or occasional calorie restriction can jumpstart autophagy, clearing out old cells and ramping up NAD production. And managing stress through meditation or yoga can help prevent oxidative stress, allowing your NAD levels to stay stable.

For added support, consider NAD-boosting supplements that contain clinically proven precursors such as Vitality ↑® NAD+ Booster. These can help optimize your NAD+ levels, supporting your journey toward achieving your ideal weight and physique.

If you’re experiencing symptoms like fatigue, weight gain, or difficulty shedding pounds, it could be a sign of NAD deficiency. Taking an Intracellular NAD Test can help you assess your baseline levels, giving you a clearer picture before starting any interventions.

With regular testing, you can fine-tune your supplementation and track whether your current dosage or supplement is effectively supporting your weight loss goals.

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Referenced Sources:

Can NAD Boosters Turn Back the Clock on Aging?

Written by Jinfiniti Science on November 5, 2024. Posted in NAD, NAD+, NAD+ Precursors, Premature Aging. No Comments on Can NAD Boosters Turn Back the Clock on Aging?

The quest for staying young has fascinated humans for centuries. While we haven’t found the fountain of youth, scientists have discovered something intriguing: NAD, short for nicotinamide adenine dinucleotide, a molecule that plays an all-important role in how we age.

As our NAD levels naturally decline over time, researchers are exploring whether boosting these levels could help slow down the aging process. But can these NAD boosters—ranging from supplements like nicotinamide riboside and NMN to therapies like NAD IV infusions—actually turn back the clock, or are they just another anti-aging promise?

In this article, we discuss…

How NAD+ Boosters work to support your body’s natural NAD production and reverse the signs of aging
Why maintaining healthy NAD levels matters for your long-term health and vitality
What science tells us about the safety and results of NAD+ Boosters

What Are NAD Boosters?

NAD boosters are compounds and interventions designed to increase NAD+ levels in cells and tissues, targeting the natural decline of this critical coenzyme that occurs with aging. NAD+ is a powerful molecule found in every cell, essential for converting food into energy, repairing DNA, and supporting overall cellular health. As we age, our natural NAD+ production decreases, which can lead to reduced metabolic function, decreased energy, and potential cognitive decline.

NAD+ boosting supplements typically contain precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) among others that help replenish cellular NAD+ levels. These supplements work by providing the body with molecules that can be easily converted into NAD+, potentially supporting healthy neurologic function, improving mood, and increasing metabolism. Research suggests that NAD+ boosters may offer benefits such as enhanced mental clarity, reduced inflammation, and improved cellular energy production¹.

While NAD+ boosters show promising potential, individuals can also naturally increase their NAD+ levels through lifestyle approaches like diet, regular exercise, intermittent fasting, limiting alcohol consumption, and eating protein-rich foods. However, for those seeking a more direct approach, NAD+ precursors provide a targeted method to support cellular health and potentially mitigate age-related decline.

SHOP NAD+ BOOSTER

Do NAD+ Boosters Really Work?

You may have heard a lot of buzz about NAD+ boosters and their potential to support healthy aging and improve cellular function. But do they really work? The research so far is promising.

Numerous studies have shown that various NAD precursor compounds (often colloquially referred to as NAD boosters) effectively increase NAD+ levels in human subjects.

For example, a well-designed, randomized, double-blind, placebo-controlled trial demonstrated that regular supplementation with nicotinamide riboside (NR) significantly increased NAD+ levels in healthy middle-aged and older adults². The benefits were impressive, too, including reduced blood pressure and improved arterial flexibility.

Another study that combined NR with pterostilbene (NRPT) reported a 40% increase in NAD+ levels after just four weeks, with sustained improvements over eight weeks³. These findings suggest that certain NAD boosters can be a safe and effective way to enhance NAD+ metabolism and potentially deliver health benefits that combat aging.

However, the reality is that not everyone will experience the same results. Individual responses to NAD boosters can vary widely. Factors such as your baseline NAD+ levels, age, gender, genetics, and overall health play significant roles in how well these interventions work for you.

For example, some studies have reported modest increases in NAD+ levels of 40-59% with lower doses of NR or NMN, while others have observed more substantial increases—up to 5.7-fold—with higher doses⁴. Ultimately, it comes down to how your body metabolizes these compounds.

What works for your friend or family member might not work as well for you, and finding the right dosage or formulation can take some trial and error. Moreover, various therapeutic approaches, such as NAD supplementation versus IV therapy, will tend to yield distinct outcomes.

Since everyone’s health needs differ, it’s always recommended to consult with your healthcare provider regarding the appropriateness of any new intervention or supplementation regime for your specific situation.

Potential Benefits of NAD Boosters

When your body maintains optimal levels, the benefits of NAD can touch virtually every aspect of your health and well-being, from energy production to DNA repair. Here’s how optimizing your NAD+ levels may help support your body:

Supporting heart health and circulation: NAD+ promotes cardiovascular function and healthy blood flow⁵.
Enhancing metabolic function: NAD+ aids in efficient energy metabolism⁶ and blood sugar regulation.
Boosting brain health and cognitive function: NAD+ improves mental clarity, memory, and overall brain performance⁷.
Increasing muscle strength and athletic endurance: NAD+ enhances physical performance⁸ and muscle recovery.
Reducing chronic inflammation: NAD+ helps lower inflammation⁹, supporting a healthier immune response.
Improving sleep and rest quality: NAD+ encourages better sleep patterns¹⁰ and more restorative rest.
Alleviating symptoms of anxiety and depression: NAD+ may help regulate mood and reduce feelings of stress and anxiety¹¹.
Supporting cellular energy production: NAD increases ATP production¹², combating fatigue and boosting daily energy.
Promoting skin repair and slowing aging: Supports skin regeneration and reduces visible signs of aging¹³.

Many people notice these improvements within weeks of starting NAD boosters, though individual results may vary. The key is consistency – giving your body the regular support it needs to maintain optimal NAD+ levels and function at its best.

Are NAD Boosters Safe?

NAD precursors are known for their strong safety profile. In fact, most people tolerate them well when taken as recommended¹⁴. However, like any supplement or medication, NAD boosters can come with potential side effects, particularly if misused or taken in excessive amounts.

Generally, side effects from NAD boosters are rare and mild. If they do occur, they may include temporary stomach discomfort, mild headaches when first starting, fluctuations in energy levels, or occasional changes in sleep patterns. These effects typically improve as the body adjusts to the supplement.

If you’re considering NAD IV therapy, it’s essential to have the procedure performed by a skilled healthcare professional to reduce the risk of complications, such as infection, vein irritation, and other possible side effects of NAD IV therapy.

Moreover, if you are pregnant, nursing, have underlying health conditions, take prescription medications, or have autoimmune disorders, it’s important to consult your doctor before using supplements like NAD boosters, as these supplements could cause side effects or interact with your medications.

To get the most from NAD boosters while minimizing risks, choose high-quality products from reputable brands, begin with the recommended dosage, and pay attention to how your body responds. Always communicate with your healthcare provider and schedule regular check-ups to monitor your progress.

Ultimately, while NAD boosters are safe and can support healthy aging and cellular function for most individuals, they are most effective when combined with a balanced lifestyle, including proper nutrition, regular exercise, and quality sleep.

Who Should Consider Taking NAD Boosters?

While NAD+ levels are generally higher in younger populations, everyone can potentially benefit from supporting their NAD+ balance, depending on lifestyle, health needs, and age-related decline.

For younger individuals, NAD+ levels are typically sufficient to support metabolic and cellular functions, making supplementation less necessary. However, children and young adults experiencing high stress, engaging in intense physical activities, or recovering from health issues may still benefit from maintaining balanced NAD levels.

For adults, especially those in their 40s and older, the natural decline in NAD+ becomes more pronounced, often leading to reduced energy, a slower metabolism, and cognitive changes. At this stage, NAD boosters can help counteract age-related declines, enhance energy levels, and support overall cellular health.

Individuals experiencing symptoms of NAD deficiency, such as persistent fatigue, cognitive difficulties, or metabolic issues, should consider getting their NAD levels tested to determine if intervention is needed. The Intracellular NAD Test provides a precise measurement of cellular NAD levels, helping identify deficiencies that may benefit from targeted NAD-boosting strategies. For those with confirmed low NAD levels, implementing appropriate interventions can help restore optimal cellular function and improve overall wellbeing.

TEST YOUR NAD LEVELS

Choosing the Right Supplement to Boost NAD

Choosing the best NAD+ supplement is important for maximizing its health benefits, and your decision should be guided by factors such as bioavailability, cost, form, and overall product quality.

For the best results, look for supplements that contain highly absorbable forms of pure NAD precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), both of which can effectively increase NAD levels in the body.

When choosing a NAD+ booster, quality and purity should never be compromised. Always select products from reputable brands that perform rigorous testing for safety and purity. Third-party lab testing ensures the supplement is free from contaminants and delivers the promised potency.

Jinfiniti’s Vitality ↑® NAD+ Booster stands out with its clinically proven, patent-pending formulation that combines four powerful ingredients to optimize NAD levels and revitalize cellular function. This unique blend includes an NAD precursor, creatine monohydrate, D-ribose, and nicotinamide, working synergistically to enhance NAD production through multiple pathways. The formulation is particularly effective as it includes both a one-step NAD precursor and supports the salvage pathway that recycles nicotinamide, while creatine monohydrate serves as an ATP energy reservoir and potential neurotransmitter. All ingredients in Vitality NAD are third-party tested for the highest purity, with Certificates of Analysis available upon request.

DISCOVER VITALITY ↑®

Referenced Sources:

10 Major Health Benefits of NAD

Written by Jinfiniti Science on October 31, 2024. Posted in NAD, NAD+. No Comments on 10 Major Health Benefits of NAD

Short for Nicotinamide Adenine Dinucleotide, NAD is an essential coenzyme naturally present in every cell of the body that has become popular for its profound effects on human health.

As we age, our NAD levels decline, which can lead to a host of age-related ailments ranging from cognitive decline to chronic fatigue. However, with the advent of NAD supplements and therapy, it’s now possible to counteract these effects, potentially reversing the signs of aging.

Recent studies show that maintaining optimal NAD+ levels in check can have a real impact on health, supporting everything from cellular repair to brain health. In fact, it could be a key player in helping you feel and function at your best.

So, how can NAD+ truly make a difference in your health?

In this article, you’ll discover:

10 surprising benefits of NAD that go beyond just boosting energy

The different benefits of NAD supplements and NAD IV therapy, and how each could support your wellness goals

Important safety guidelines, potential side effects, and who might benefit the most from NAD therapy

What is NAD?

Every cell in your body relies on a molecule called NAD, short for nicotinamide adenine dinucleotide, to keep the lights on. This coenzyme is like a molecular power plant, essential for turning food into energy and for keeping countless biochemical reactions running smoothly.

NAD exists in two forms, NAD+ and NADH¹, which function together in redox reactions to facilitate energy production, DNA repair, and cellular signaling

NAD+ is the oxidized form of the molecule, capable of accepting electrons during metabolic processes², which is crucial for energy production and various biochemical reactions. In contrast, NADH is the reduced form that results when NAD+ gains electrons.³ This conversion allows NADH to act as an important electron carrier, shuttling electrons to support cellular functions.

Unfortunately, NAD+ levels don’t remain stable throughout our lives.⁴ In fact, they naturally decline over time. By the time we hit middle age, our NAD+ levels could be nearly half of what they were in our youth.

As we age, our bodies produce less NAD+ due to a combination of factors, including accumulated DNA damage, changes in metabolic processes, and increased activity of NAD+-consuming enzymes.⁵ This drop can lead to slower cellular functions, less efficient DNA repair, and even faster aging at the cellular level.

Researchers have found that this decline in NAD+ can lead to various age-related issues,⁶ like fatigue, and cognitive decline, and even increase vulnerability to diseases such as cardiovascular disease and obesity.

No wonder why NAD supplements have become popular in optimizing NAD levels and supporting healthy aging.

What are NAD Supplements?

NAD+ supplements are products developed to help increase levels of NAD+ in the body, especially as we age, when our levels significantly decline. They come in various forms — such as powders, capsules, and tablets which are convenient for daily use.

There are also sublingual strips that dissolve under your tongue for quicker absorption. If you have trouble swallowing pills, NAD+ supplements are also available in liquid forms.

The best NAD supplements contain pure NAD+ precursors, which are building blocks your body uses to make NAD+. The most common precursors are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

NR is a form of vitamin B3 that the body can easily convert into NAD+. Many people take NR to boost their energy levels and support healthy aging. It may even help with exercise performance⁷, making it a favorite among fitness enthusiasts.

Like NR, NMN also helps increase NAD+ levels in the body. It’s particularly effective at supporting cellular health and promoting longevity. Research has shown that NMN can benefit heart health⁸ by protecting heart cells from age-related damage.

It can also support healthy metabolic function, energy production, and overall cellular health, which is crucial for maintaining vitality and combating age-related declines.

Therefore, with the right NAD supplement, you can potentially counteract the many symptoms of NAD deficiency that most people experience as they get older.

NAD Supplement Benefits

Is your NAD level optimized? It should be! Here are 10 of the major therapeutic benefits of optimal NAD levels.

NAD supports cellular health, potentially extending lifespan

NAD+ is essential for cellular health, supplying the energy cells need to function effectively and supporting DNA repair to keep our genetic material intact and healthy. Additionally, it activates sirtuins, known as “longevity proteins,”⁹ that help manage inflammation and aging. By energizing cells and promoting effective repair, optimized NAD levels may extend our lifespan and help keep our bodies healthy as we grow older.

NAD promotes heart health and circulation

NAD+ supplementation shows promise in improving cardiovascular health by improving heart function and vascular integrity. Studies have demonstrated that NAD+ precursors can reduce high blood pressure, ameliorate vascular dysfunction, and decrease arterial stiffness in hypertensive patients and animal models.¹⁰ NAD+ replenishment has been shown to protect against age-related arterial stiffening, improve endothelial function, and potentially reduce the risk of cardiovascular events.¹¹

NAD plays a role in maintaining metabolic health

NAD+ also supports fat-burning and glucose metabolism,¹² which play an essential role in maintaining a healthy weight. NAD+ boosts energy production, which helps improve overall metabolism, making it easier for the body to manage its energy levels. This leads to better energy balance and reduces the risk of metabolic disorders like obesity and diabetes.

NAD can help improve cognitive function

NAD+ also boosts brain health by generating the energy needed for mental clarity, focus, and sharp thinking. It supports DNA repair and healthy inflammatory responses in the brain, which is protective against age-related cognitive decline and neurodegenerative disorders.¹³ With optimal NAD+ levels, you may notice sharper memory, better focus, and clearer thinking.

NAD boosts muscle strength and athletic endurance

If you’re an athlete, a bodybuilder, or simply just an active person, NAD+ can boost your athletic performance. Thanks to its ability to fuel your body with the energy needed for muscle contractions during exercise.¹⁴ It also supports muscle recovery by promoting repair and reducing fatigue after workouts. This means you can train harder, recover faster, and improve your overall performance in sports and any physical activities.

NAD reduces chronic inflammation in the body

NAD+ plays a consequential role in managing chronic inflammation.¹⁵ It supports your immune system and regulates inflammatory responses, significantly reducing your risk of health issues like heart disease and arthritis. Maintaining optimal NAD+ levels allows your body to promote healthy inflammation processes, ultimately helping you feel better and healthier over time.

NAD may improve sleep patterns and overall rest quality

NAD+ also supports your body’s internal clock,¹⁶ a key factor in getting quality sleep. When NAD+ levels are high, they drive up the production of melatonin, the drowsy-making hormone that tells your brain “it’s time to drift off.” With robust NAD+ levels, you’re more likely to sink into the kind of deep, restorative sleep that leaves you bouncing out of bed in the morning, sharp-minded and energized, rather than fighting with your snooze button.

NAD could alleviate symptoms of anxiety and depression

Keeping your NAD+ levels in check can help your brain’s neurotransmitters—like serotonin and dopamine—work more effectively. These chemicals play a big role in how we feel, so with a better balance of them, you might notice a drop in anxiety and depression,¹⁷ along with an overall mood lift.

NAD increases cellular energy production, fighting fatigue

You can also combat fatigue effectively with the help of NAD supplements. NAD+ is a key player in mitochondrial function, converting nutrients from food into usable energy for your cells. With an optimized NAD+ level, your body can generate energy more efficiently, reducing tiredness throughout the day.¹⁸

NAD supports skin repair and slows visible signs of aging

Last but certainly not least, NAD+ contributes to skin repair and helps slow visible signs of aging. It promotes cell regeneration, keeping your skin looking healthy and youthful. When your NAD levels are optimized, your skin gains remarkable resilience against environmental assaults – from harsh UV rays to urban pollutants.¹⁹ Over time, this leads to a more even skin tone, fewer wrinkles, and a radiant complexion that truly glows.

SHOP NAD+ BOOSTER

Potential Benefits of NAD Therapy

Outside of supplementation, NAD therapy is quickly becoming a popular choice for those looking to increase NAD levels. This treatment involves infusing the body with NAD+ directly without the delays of digestion.

During the session, a healthcare provider places a small IV line in your arm, and the NAD+ solution is infused over a set time. The goal is to achieve rapid absorption and effects without going through the digestive system.

Regular NAD therapy sessions can offer several potential benefits:

Feeling a surge of natural energy that lasts throughout your day
Experiencing sharper focus and clearer thinking, like a mental fog has lifted
Watching as your body repairs itself more efficiently
Finding yourself handling stress better while enjoying a more balanced mood
Getting extra support in managing ongoing health challenges
Noticing a more youthful appearance and improved vitality over time

Safety and Tolerability of NAD Therapy

NAD therapy is generally considered safe for most people, but like any treatment, it comes with potential risks and safety concerns. Some people may experience mild side effects of NAD therapy during or after sessions. Common reactions include:

Nausea
Headaches
Fatigue
Flushing or warmth
Dizziness
Mild anxiety
Changes in heart rate

More serious side effects are rare but can also occur. Some people may experience allergic reactions, which could manifest as rashes, itching, or swelling. Therefore, it’s important to monitor how your body responds during and after the treatment, especially if you have a history of allergies.

Additionally, complications related to IV administration can arise,²⁰ such as infection at the injection site, vein irritation, or blood clots. Although these are uncommon, your NAD IV must be done by a trained professional in a sterile environment to minimize risks.

Finding the right dose of NAD+ for therapy is also important for achieving desired results without unnecessary side effects. The optimal dosing may vary based on individual needs, age, and health status. Typically, doses can range from 250 mg to 1,000 mg per session, administered intravenously for one to three hours, or even longer.

Your healthcare provider can help you determine the best protocol for you based on your specific circumstances and treatment goals.

Who is NAD Therapy For?

NAD therapy can be of great benefit to many people, including:

Individuals experiencing persistent fatigue
Those with cognitive performance concerns
Athletes and fitness enthusiasts
Individuals in addiction recovery
Those focused on healthy aging

Like any treatment, NAD therapy isn’t for everyone. Although NAD therapy is generally well-tolerated, it may not be suitable for:

People with severe kidney or liver conditions
People with known allergies to NAD+ infusion components
Pregnant or nursing individuals

Is NAD Supplementation Right for You?

While NAD levels naturally decline with age, supplementation provides a science-backed approach to maintaining optimal cellular health. The extensive benefits we’ve explored – from enhanced energy production and cognitive function to improved metabolic health and longevity support – make NAD supplementation an attractive option for many adults seeking to optimize their wellness.

Research consistently shows that NAD supplementation is generally well-tolerated, with minimal side effects reported in clinical studies. However, before starting any new supplement regimen, it’s valuable to understand your baseline levels. Testing your intracellular NAD levels can provide clear insights into whether supplementation would be beneficial for your specific situation.

Jinfiniti’s Intracellular NAD® Test offers precise, laboratory-grade testing that measures NAD where it matters most – inside your cells. This testing can help establish your baseline levels and allow you to track your progress while supplementing, ensuring you’re achieving optimal results from your NAD support strategy.

TEST YOUR NAD LEVELS TODAY

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NAD Deficiency Symptoms: 6 Common Signs of Low NAD Levels

Written by Jinfiniti Science on October 28, 2024. Posted in Depression and Anxiety, Energy and Fatigue, Memory Loss and Brain Fog, NAD, NAD+, Skin Health, Sleep. No Comments on NAD Deficiency Symptoms: 6 Common Signs of Low NAD Levels

Feeling sluggish, mentally foggy, or struggling to keep up with your routine lately?

While it’s quite normal to feel this way from time to time, you shouldn’t take these frustrating signs for granted.

What seems like just another bad day could be a telltale sign that your NAD+ levels are running low.

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that plays a critical role in energy production, DNA repair, and overall health.

Unfortunately, NAD+ levels naturally decline with age and can be further affected by lifestyle factors, leading to a range of symptoms that are often overlooked.

So, what are these warning signs, and how can you optimize your NAD+ levels to stay healthy and active as you age?

In this article, we discuss:

Why your NAD levels are dropping faster than you think—and it’s not just because you’re getting older.

7 subtle signs of NAD deficiency that many people dismiss as “just part of aging,” but shouldn’t.

The red flags of severe NAD deficiency you can’t afford to ignore.

How to accurately detect low NAD levels in your body and the easiest, most effective ways to boost them naturally.

Understanding NAD+ and Why It Declines

Nicotinamide adenine dinucleotide, or NAD+, is an essential coenzyme found in every cell of our body. It plays a key role in several critical processes, including energy metabolism, DNA repair, and cellular signaling.¹

Essentially, NAD+ acts like a shuttle for electrons during metabolic reactions, helping to transform the food we consume into usable energy and supporting the production of ATP, which is the main energy currency for our cells.

Beyond just energy production, NAD+ also maintains the integrity of our DNA and regulates various cellular functions that keep us healthy.

Unfortunately, by the time we reach our 30s, our NAD+ levels start to decline. In fact, NAD+ can decrease by up to 50% as we age,² with noticeable reductions in the skin and other tissues.

This decline can be accelerated by factors like oxidative stress,³ unhealthy diets, and lifestyle choices, leading to symptoms that are often mistaken for the typical signs of aging.

But in reality, these may be early signs of low NAD+ levels, indicating that it’s time to take action and make necessary lifestyle changes to support your health and longevity.

Common Symptoms of NAD+ Deficiency

Below are six common health symptoms that indicate you may be deficient in NAD.

Fatigue and Low Energy

NAD is essential for energy metabolism. Think of it as the engine that powers your body, helping convert the food you eat into usable energy. However, when your NAD+ levels drop, it can disrupt your metabolism and may result in fatigue and low energy.

Your body might also struggle to produce ATP (adenosine triphosphate), which is your main source of energy. The result? You might feel sluggish and worn out. NAD+ also supports the proper functioning of enzymes that protect against oxidative damage.

When these protective enzymes can’t do their job because of low NAD levels, it creates an imbalance between harmful reactive oxygen species and protective antioxidants⁴ that can further drain your energy and leave you feeling even more fatigued.

Moreover, NAD+ is important in metabolizing carbohydrates, fats, and proteins. When your NAD+ levels are low, these metabolic pathways can become inefficient, leading to even more tiredness. For instance, if your body can’t break down fatty acids properly, it can accumulate unused substrates that sap your energy.

Not to mention, during physical activity, your muscles depend heavily on NAD+ for energy.⁵ If you’re low on NAD+, you might experience muscle weakness and decreased endurance, making even simple tasks feel much more challenging.

Cognitive Symptoms

NAD is also important for maintaining healthy cognitive function. When your levels drop, you might start to notice some cognitive symptoms, such as mental fog, memory lapses, and a general decline in sharpness.

This is because NAD+ is crucial for energy metabolism and mitochondrial function, both of which are essential for your brain to perform at its best. When NAD+ levels are low, the brain struggles to produce adenosine triphosphate (ATP)⁶—the energy that powers our cells—leading to sluggish thinking and that frustrating feeling of mental cloudiness or fatigue.

Research shows that a deficiency in NAD+ can worsen neuroinflammation and oxidative stress, both of which are harmful to cognitive health, potentially leading to increased neuronal damage and cognitive issues,⁷ such as forgetfulness and decreased mental agility.

Skin and Appearance Changes

Is your skin looking dry and dull despite your diligent skincare routine and healthy lifestyle? One hidden culprit could be low NAD+ levels.

Research shows that low NAD+ levels can hinder your skin’s ability to repair itself, particularly from damage caused by sun exposure. This impairment can result in more visible signs of aging, such as wrinkles and loss of elasticity.

Additionally, because NAD+ plays a key role in supporting mitochondrial function—the process that provides the energy your skin cells need to regenerate and stay vibrant⁸—low NAD+ levels can impede cell renewal. This leaves your skin looking tired, dull, and less radiant.

Poor Sleep Quality

Having trouble getting a restful night’s sleep? It could be more than just stress or a racing mind—it might actually be a deficiency in NAD+ levels.

As a coenzyme, NAD+ supports energy production and maintains healthy cells, including those involved in regulating your sleep cycle. When NAD+ levels decline, especially as we age, this drop can disrupt your sleep patterns.

Since NAD+ helps regulate key “clock” genes that control your sleep-wake cycle, it can throw off your body’s internal clock, or circadian rhythm,⁹ making it harder to fall asleep or stay asleep through the night.

Research also reported that NAD+ is essential for the synthesis of serotonin from tryptophan, a precursor amino acid.¹⁰ If NAD+ levels drop, this metabolic pathway can become inefficient, potentially leading to reduced serotonin and subsequently lower melatonin levels.

Therefore, you may experience sleep disturbances and increased fatigue due to inadequate melatonin production.

Mental Health and Mood Swings

Low NAD+ levels can significantly affect your mood and mental health, often manifesting as mood swings, irritability, anxiety, or even depression.

This occurs because NAD+ deficiency disrupts the balance of crucial neurotransmitters like serotonin, dopamine, and norepinephrine,¹¹ which are essential for regulating mood and emotional responses. As a result, you may experience persistent feelings of anxiety or sadness.

NAD+ is also important in activating sirtuins—proteins that help cells manage stress.¹² When NAD+ levels are low, sirtuins become less effective, which can contribute to mental health challenges like anxiety and irritability.

This makes it harder for your brain to cope with stress, intensifying emotional imbalances.

Metabolic Health Issues

NAD+ deficiency can lead to various metabolic problems,¹³ including weight gain, insulin resistance, and a higher risk of metabolic disorders.

NAD+ underpins key metabolic processes like glycolysis, the TCA cycle, and oxidative phosphorylation. When NAD+ levels drop, these processes become less efficient, disrupting energy metabolism and contributing to issues such as weight gain and insulin resistance.

Low NAD+ also affects enzymes involved in energy production, leading to reduced ATP synthesis and increased fat storage, particularly in the liver and fat tissue. This buildup of fat triggers inflammation, further worsening insulin resistance.

Moreover, NAD+ activates sirtuins, proteins that help regulate glucose and fat metabolism. When NAD+ levels are low, sirtuin activity declines, making it harder for the body to control blood sugar and insulin sensitivity,¹⁴ which raises the risk of type 2 diabetes.

People with low NAD+ levels are also more prone to developing metabolic conditions like diabetes and non-alcoholic fatty liver disease (NAFLD).

Severe NAD+ Deficiency Symptoms

People with NAD+ deficiency may also experience severe symptoms similar to pellagra, a condition caused by niacin deficiency.¹⁵

These symptoms indicate a critical lack of NAD+.

Dermatitis typically manifests as a scaly rash that worsens with sun exposure, indicating the body’s diminished capacity for healing due to low NAD+ levels. Diarrhea stems from impaired gut function and disrupted metabolism, which can lead to dehydration and poor nutrient absorption. Cognitive issues like memory loss and confusion arise because NAD+ is integral for brain cell energy production and neuronal health.

If left untreated, NAD+ deficiency can result in severe metabolic dysfunction,¹⁶ increasing the risk of serious conditions such as cardiovascular disease, diabetes, neurodegenerative disorders, and even death.

Cardiovascular Impact of NAD+ Deficiency

Low NAD+ levels can greatly increase the risk of cardiovascular diseases,¹⁷ hypertension, and reduced heart function. When NAD+ levels decline, vital processes like energy metabolism, DNA repair, and oxidative stress management become compromised, leading to a range of cardiovascular issues, especially hypertension.

Research published in the Signal Transduction and Targeted Therapy shows that hypertensive patients have a 44% lower NAD+ level in their peripheral blood mononuclear cells¹⁸ compared to those with normal blood pressure. This reduction is closely linked to impaired vascular function and elevated arterial pressure.

Additionally, NAD+ deficiency can cause mitochondrial dysfunction, which is crucial for maintaining cardiac energy metabolism.¹⁹ This leads to reduced ATP production and increased oxidative stress, both of which contribute to heart failure and other cardiovascular problems.

The enzyme CD38, which depletes NAD+, is often overactive in hypertensive individuals, further draining NAD+ levels and negatively affecting vascular health and heart function.

Beyond hypertension and weakened heart function, chronically low NAD+ levels can increase the risk of severe cardiovascular diseases like atherosclerosis and coronary artery disease,²⁰ which, if not addressed, can result in life-threatening events such as heart attacks and strokes.

NAD+ Deficiency in Specific Populations

While it’s common knowledge that NAD+ levels decline after the age of 30, certain groups are at a higher risk of experiencing a deficiency.

Obese individuals, for example, tend to have significantly lower NAD+ levels²¹ than those with a healthy weight. This is because excess fat triggers chronic inflammation and metabolic imbalances, which further deplete NAD+ levels.

Obesity is also associated with impaired NAD+ metabolism, increasing insulin resistance,²² and elevating the risk of type 2 diabetes and related conditions.

Genetic disorders also contribute to NAD+ deficiency risk. Individuals with conditions like congenital NAD deficiency disorder (CNDD)²³ experience inadequate NAD+ production, leading to developmental abnormalities and other health complications.

Genetic mutations that interfere with enzymes responsible for NAD+ synthesis reduce the availability of this vital coenzyme, contributing to congenital defects and increased health risks.

Given all these factors, the important question is: Are you NAD+ deficient? The only way to find out is to test.

How to Test if Your NAD Levels Are Low

Now that you understand the signs of NAD deficiency, how do you find out if your NAD levels are truly suboptimal?

At Jinfiniti, we prioritize precision over guesswork. That’s why we recommend the most reliable approach: testing your NAD+ levels directly.

Our Intracellular NAD Test gives you a clear picture of what’s happening inside your cells. We measure your actual NAD+ levels to help you see where you stand – whether they’re running low, sitting at a healthy baseline, or higher than average. With these insights, you can make smarter decisions about your NAD+ supplements and know if they’re really working for you.

TEST YOUR NAD LEVELS TODAY

How to Treat Low NAD Levels

If you suspect your NAD+ levels are low or have confirmed a deficiency through testing, there are several evidence-based approaches to increase your NAD+ levels naturally and through supplementation. The key is finding the right combination of lifestyle modifications and targeted support for your individual needs.

Research shows that regular exercise, particularly high-intensity training, naturally boosts NAD+ production. Combining this with a diet rich in B3 vitamins and stress management techniques can help optimize your body’s NAD+ levels while preventing excessive depletion of existing stores.

For those seeking intensive support, medical NAD+ therapies like IV infusions are available at specialized clinics. While these treatments can rapidly elevate extracellular NAD+ levels, they are costly and may cause side effects like flushing and headaches, requiring close medical supervision.

A more accessible and scientifically-validated approach is supplementation with NAD+ precursors.

Our High Purity NAD+ Precursor powder offers a premium-grade, pure form of NAD+ as a building block that your body can efficiently convert into active NAD+.

For those seeking enhanced results, our breakthrough Vitality ↑® NAD+ Booster takes supplementation to the next level by combining a clinically proven NAD+ precursor with synergistic ingredients. The strategic inclusion of creatine monohydrate helps stabilize cellular energy systems, while D-ribose and nicotinamide work together to optimize NAD+ synthesis pathways.

This unique formulation has been shown to increase NAD+ levels more effectively than single-ingredient supplements, providing total support for your cellular health and energy production.

With these strategies in hand, you’ll be on the right track to treating NAD deficiency and promoting longevity.

SHOP NAD+ SOLUTIONS

Referenced Sources:

NAD Supplements vs IV Therapy: Which is Best?

Written by Jinfiniti Science on October 25, 2024. Posted in NAD, NAD+. No Comments on NAD Supplements vs IV Therapy: Which is Best?

If you’ve been searching for ways to supercharge your energy or combat the signs of aging, you’ve probably come across NAD (nicotinamide adenine dinucleotide).

But here’s the real question: Should you take it as a supplement or opt for the more intensive IV therapy?

In this article, we’ll discuss:

The key differences between NAD supplements and NAD IV therapy.
The pros and cons of each option to find out which method fits best with your lifestyle and health goals.
Why some methods of NAD delivery are more effective than others and how absorption plays a crucial role.
How to tailor your NAD supplementation using personalized testing to match your unique health needs.

What is NAD?

NAD is a vital molecule found in every living cell of the human body. It serves as a coenzyme, meaning it assists enzymes in carrying out chemical reactions essential for life. NAD exists in two forms: NAD+ and NADH.

At its core, NAD+ is an electron courier. It shuttles electrons between different molecules during cellular metabolism, the process by which cells break down nutrients to generate energy.

The body produces NAD+ through three main pathways:

De novo synthesis: Creating NAD+ from scratch using amino acids.
Preiss-Handler pathway: Utilizing dietary niacin (vitamin B3) to form NAD+.
Salvage pathway: Recycling NAD+ components, primarily nicotinamide, after it has been used by enzymes.

In mammals, including humans, the salvage pathway is the primary source of NAD+. This efficient recycling process helps maintain adequate levels of this essential molecule.

NAD’s role extends beyond basic metabolism, influencing processes like DNA repair, gene expression, and cellular aging.

Types of NAD Treatments

Boosting NAD levels has become increasingly popular, and there are several types of NAD treatments available, each with its own advantages and considerations.

Oral NAD Supplements

NAD supplements come in various oral forms, including pills, capsules and pure powders. These products contain NAD precursors or related compounds designed to elevate NAD levels in the body. When ingested, a NAD+ supplement will pass through the digestive system and enter the bloodstream, where it circulates to cells throughout the body.

Many people choose oral NAD supplements as a straightforward way to increase their NAD levels. This method appeals to those who prefer to avoid intravenous treatments, offering a more familiar and less invasive approach to supplementation.

Discover Our NAD Supplements & Test Kits

NAD IV Therapy

NAD+ IV therapy is a new treatment where NAD+ is delivered directly into your bloodstream via an intravenous (IV) drip. During the session, a healthcare professional inserts a small IV line into your arm. The NAD+ solution is infused over a set period, allowing for direct absorption into your bloodstream. This bypasses the digestive system, leading to quicker availability of NAD+.

Dosages can vary depending on your needs, but typical sessions might range from 250 mg to 1,000 mg of NAD+. Treatments usually last between 1 to 3 hours, but some can go 4 hours or even longer depending on the dose and your needs. Many people opt for multiple sessions spread over weeks or months.

Other NAD Therapies

Beyond oral supplements and IV therapy, two additional methods for increasing NAD+ levels have gained some traction: injection therapy and nasal sprays.

NAD Injections

NAD+ injections offer a middle ground between oral supplements and IV therapy. This method delivers NAD+ directly into the bloodstream through intramuscular or subcutaneous injections.

NAD Nasal Sprays

NAD+ nasal sprays are a novel approach to NAD+ supplementation. These sprays deliver NAD+ through the nasal passages, claiming to deliver rapid absorption into the bloodstream.

Pros and Cons of NAD Supplements and IV Therapy

The quest for higher levels of NAD boils down to two main contenders: pills and supplements or intravenous therapy. Both have their benefits and downsides. Here we break down the pros and cons of NAD supplements versus IV drips, so you can figure out which method is best for cellular vitality.

Effectiveness

The effectiveness of NAD supplements or IV therapy depends largely on how well the body absorbs and utilizes the different delivery methods.

NAD supplements or precursors are compounds that can be efficiently taken up by cells and converted into NAD+ through various intracellular pathways. Once inside the cell, these precursors are metabolized to increase intracellular NAD+ levels. NAD precursors increase intracellular NAD+ levels by feeding into biosynthetic pathways, thereby supporting various NAD+ dependent processes.

Unlike NAD+ precursors, which are converted into NAD+ within cells, the primary action of NAD+ IV therapy is believed to be extracellular, influencing immune responses, inflammation, and cellular signaling¹ rather than directly increasing intracellular NAD+ levels.

Oral supplements are generally well-absorbed but may take longer to produce noticeable effects. In contrast, IV therapy introduces NAD+ directly into the bloodstream, resulting in more rapid onset of effects.

While IV treatments can provide a quick boost, their effects may be short-lived. This is due to several factors:

Rapid Clearance: NAD+ is quickly eliminated from the plasma, often within two hours of infusion.
Cellular Penetration: The relatively large size of NAD+ molecules can impede their ability to cross cell membranes efficiently.
Dosage Considerations: The amount and frequency of NAD+ administration significantly impact its effectiveness.

Oral NAD+ precursors offer a more consistent and sustained approach to increasing NAD+ levels. A 2019 study² demonstrated that oral supplementation can effectively elevate whole blood NAD+ levels over time:

Dose	NAD+ Increase
100 mg	22%
300 mg	51%
1000 mg	142%

These results were observed after two weeks of supplementation.

Despite its rapid clearance from the bloodstream, NAD IV therapy may still have potential benefits for certain medical conditions, particularly some neurological and infectious diseases.

To maximize the benefits of NAD+ supplementation, it’s important to consult with a healthcare provider to determine the most appropriate method and dosage regimen for individual needs and health goals.

Convenience

Supplements are generally the easier option in terms of convenience. You can take them as pills or mix a powder into a drink, making them a quick addition to your daily routine. No special setup or assistance is needed, so you can easily incorporate them into your day.

In contrast, IV therapy requires you to visit a clinic or healthcare professional. This involves scheduling an appointment and waiting, which can be less convenient if you have a busy lifestyle. The procedure typically spans several hours, during which the patient must remain relatively stationary.

The time investment for each method differs significantly:

Oral supplements: Consumption takes mere seconds
IV therapy: Sessions last between 1 to 4 hours or more

This time disparity can be a deciding factor for individuals with demanding schedules or limited flexibility in their daily routines.

In terms of availability, supplements win hands down. Oral supplements are widely available through retail stores and online platforms. IV therapy is limited to specialized clinics, which may not be present in your geographic area.

If convenience is a top priority for you, oral supplements offer a simpler, quicker, and more accessible option compared to NAD IV infusion.

Cost

Generally, dietary supplements are much more affordable. A typical bottle of NAD+ supplements can cost anywhere from $20 to $150, depending on the brand and dosage.

On the other hand, IV treatments can range from $150 to $500 per session. That can go even higher in expensive cities or at high-end clinics with state-of-the-art equipment. Add-ons like vitamins, minerals, or hydration boosters can also push up the price, so it’s worth checking what’s included before you book!

This price difference makes supplements a more accessible choice for daily or regular use. While supplements are more wallet-friendly, it’s also important to think about the long term.

If you’re considering regular IV therapy, those costs can add up quickly. For example, if you plan to have one treatment a month, that could mean spending anywhere from $1,800 to $6,000 a year.

The price disparity between these methods is substantial:

Method	Cost per Unit	Estimated Annual Cost (Monthly Use)
Oral	$20-$150/bottle	$240-$1800
IV	$150-$500/session	$1,800-$6,000

It’s essential to evaluate how often you intend to receive these treatments and whether they fit your budget in the long run. Your decision should take both immediate and ongoing expenses into account.

Safety and Side Effects

Supplements are generally safe and well tolerated, particularly in the forms of NAD precursors when taken at recommended doses. Studies have shown that they have a favorable safety profile and are relatively safe for use as a dietary ingredient³.

A study conducted in Japan found that a single oral dose of NAD precursor supplement up to 500 mg is safe for healthy men. Researchers observed no significant changes in vital signs like heart rate, blood pressure, or body temperature.⁴

However, for some individuals, they can experience common side effects like muscle pain, fatigue, sleep disturbances, and headaches⁵. These symptoms are usually short-lived and resolve quickly.

IV therapy, while highly effective for certain conditions, also carries additional risks.⁶ Patients may experience pain, bruising, or swelling at the site of infusion. Some individuals have reported additional NAD IV therapy side effects that impact the entire body, including headaches, fatigue, and nausea. These reactions can differ in intensity from person to person.

In rare cases, IV therapy can lead to serious complications, like infections or allergic reactions⁷.

Additionally, NAD IV therapy has been linked to higher levels of high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation. Our research has found that about 70% of people who receive NAD IV therapy experience a 3- to 10-fold increase in hs-CRP levels, which can trigger an inflammatory response in some individuals.

Elevated hs-CRP levels are assoicated with an increased risk of cardiovascular (CV) events and atherosclerosis⁸. Therefore, monitoring hs-CRP levels and finding effective ways to manage inflammation is crucial for keeping patients safe during and after treatment.

Before starting either treatment, it’s also important to consider contraindications. Certain medical conditions can also make these therapies unsuitable.

Also, keep in mind that age can play a role. Older adults might respond differently due to various health issues or changes in metabolism. If you’re pregnant or breastfeeding, it’s also important to consult your healthcare provider as well, since the effects of NAD therapies in these cases aren’t fully understood yet.

Always take the time to discuss any new supplements or therapies with your healthcare provider. They can help ensure that whatever you choose is a safe fit for your individual health needs and circumstances.

Staying informed and cautious is key!

Choosing Between NAD Supplements or IV Therapy

NAD supplements provide a convenient and accessible method for long-term NAD support. These supplements are typically taken daily and can be easily integrated into existing routines. Clinical data suggests that oral NAD precursors can effectively raise intracellular NAD levels over time.

Benefits of NAD Supplements:

Can increase intracellular NAD+
Convenience of at-home use
Lower cost compared to IV therapy
Suitable for long-term, consistent use
Minimal risk of complications

Considerations:

Slower onset of effects
Potential for reduced bioavailability due to digestive processes

IV NAD therapy delivers NAD directly into the bloodstream, bypassing the digestive system. This method allows for rapid absorption and potentially higher bioavailability.

Benefits of NAD IV Therapy:

Rapid onset of effects
May be beneficial for acute conditions or rapid recovery

Considerations:

Requires clinical administration
Higher cost per treatment
Time-intensive procedure
Potential for adverse reactions
Influences signaling and metabolism outside the cell

The decision between oral supplements and IV therapy should be based on individual health needs, goals, and practical considerations.

Oral Supplements May Be Preferable For:

General wellness and anti-aging support
Long-term NAD maintenance
Those seeking a cost-effective, convenient option

IV Therapy May Be More Suitable For:

Individuals with acute health concerns requiring rapid intervention
Those with conditions affecting nutrient absorption
Athletes or individuals recovering from intense physical exertion

In some cases, a combination approach may be beneficial. For example, initiating treatment with IV therapy rapid delivery of extracellular NAD+, followed by oral supplementation to increase intracellular NAD+ levels and provide sustained benefits.

If you’re unsure about your current NAD levels, our intracellular NAD test can provide valuable insight and help you tailor your approach. Understanding your NAD status can guide your decision on whether to start with supplements, IV therapy, or a combination of both.

TEST YOUR NAD LEVELS TODAY

Frequently Asked Questions

What are the benefits of NAD supplements?

NAD supplements offer potential long-term health benefits. NAD precursors have been shown to boost cellular energy production and support the body’s repair mechanisms. Research suggests they may contribute to slowing certain aspects of biological aging.

Are NAD Supplements as Effective as IV?

NAD+ IV therapy offers potential benefits for individuals with conditions like dementia, addiction, Lyme disease, and long COVID. This treatment delivers a high dose of NAD+ directly into the bloodstream, providing rapid but short-term relief. However, the effects are temporary, and the therapy requires administration by healthcare professionals in clinical settings.

For long-term benefits, including improved energy, performance, and longevity, intracellular NAD+ levels need to be increased. Oral NAD+ precursor supplements, available in pill or powder form, offer a more practical and sustainable approach. These supplements can be easily incorporated into daily routines and are designed to boost intracellular NAD+ levels over time.

Who should avoid or take NAD supplements?

Aging adults might find these supplements helpful as NAD levels naturally decline with age, potentially supporting cellular energy production and DNA repair. Athletes and fitness enthusiasts may be drawn to NAD’s role in energy metabolism, which could enhance physical performance and recovery. Individuals with specific health concerns, such as conditions linked to mitochondrial dysfunction or metabolic disorders, might also benefit from NAD supplementation.

However, certain groups should exercise caution. Pregnant or nursing women should avoid NAD supplements due to limited research on their effects during pregnancy and lactation, unless directed by a healthcare provider. Individuals with liver disease, kidney problems, or certain types of cancer should consult their doctor before use, as these supplements may interact with their condition or treatment.

Discover our NAD test kit to determine your levels and personalize your supplementation.

Discover Your NAD+ Levels with Jinfiniti

Curious about your NAD+ levels?

Jinfiniti offers an easy way to find out where you stand.

Understanding your NAD+ status can help you tailor your health approach, whether you’re aiming for energy boosts, better recovery, or overall wellness.

Our testing process is simple and provides valuable insights that can inform your next steps, whether you choose supplements, IV therapy, or both.

Discover your NAD+ levels with Jinfiniti today and discover your way to a more vibrant life. Knowing your body’s needs is the first step toward optimizing your health journey!