Chronic fatigue is a debilitating condition that affects millions of people worldwide. 

According to the Centers for Disease Control and Prevention (CDC), around 2.5% of adults in the United States report experiencing fatigue that is severe enough to interfere with their daily lives.¹

People with chronic fatigue often describe feeling exhausted and worn out, even after getting plenty of rest. 

This persistent fatigue can significantly impact their quality of life, making it difficult to work, socialize, or even perform simple tasks.

In fact, in 2022, 13.5% of adults aged 18 and older reported feeling very tired or exhausted most days or every day in the past three months², according to CDC.

Fatigue is a common reason for seeking medical care and a source of considerable economic burden.

Just take a look at the graph below:

Among men, the percentage was highest among those aged 18–44 years, followed by those aged 45–64 years, and then those aged 65 years and older (8.9%).

Among women, the decline in the percentage with age was steeper, decreasing from 20.3% to 15.3% (45–64 years) and to 11.5% (65 years and older).

The percentage of adults who felt tired or exhausted most days or every day was higher for women compared with men in each age group.

AND… those who are tired all the time seem to die more likely, as suggested by the lower percentages in those older than 65 years.

There are several reasons why people may experience chronic fatigue. Here are the top three:

3 Major Reasons For Chronic Fatigue

Stress

Stress is a complex phenomenon that can have profound effects on the body, including contributing to the development and exacerbation of chronic fatigue. This is due to several factors:

First, stress activates the HPA axis, leading to the release of cortisol, the body’s primary stress hormone. 

Chronic stress can dysregulate the HPA axis, resulting in abnormal cortisol levels. A study published in the Journal of Psychiatric Research found that individuals with chronic fatigue syndrome (CFS) often exhibit abnormalities in the HPA axis³, suggesting a link between stress and fatigue in these individuals.

Chronic stress can also lead to systemic inflammation and immune dysregulation, which have been implicated in the pathophysiology of chronic fatigue. 

A study published in Psychoneuroendocrinology (PMID: 18614268) found that stress-induced increases in inflammatory markers were associated with increased fatigue severity in patients with chronic fatigue syndrome.⁴ 

Moreover, chronic stress can also lead to alterations in neuroendocrine function, including changes in neurotransmitter levels and receptor sensitivity. 

These neuroendocrine changes can affect mood, energy levels, and fatigue. 

A study published in Psychological Medicine) found that alterations in the serotonin system, which is involved in mood regulation, were associated with increased fatigue in people.⁵ 

In conclusion, stress can contribute to chronic fatigue through various mechanisms, including HPA axis dysregulation, inflammation and immune dysregulation, and neuroendocrine changes. 

Poor Sleep Quality

Poor sleep quality is a common complaint among people with chronic fatigue and plays a significant role in the development and exacerbation of fatigue. 

Research has identified several ways in which poor sleep quality can contribute to chronic fatigue:

Poor sleep quality often manifests as sleep fragmentation, characterized by frequent awakenings throughout the night. 

A study published in the Journal of Clinical Sleep Medicine found that sleep fragmentation disrupts the normal sleep cycle⁶, leading to non-restorative sleep and increased fatigue.

Another way poor sleep quality contributes to chronic fatigue is through alterations in sleep architecture, such as reduced slow-wave sleep and disturbances in rapid eye movement (REM) sleep. 

A study published in Sleep Medicine Reviews (PMID: 26298830) found that alterations in sleep architecture can lead to daytime sleepiness and fatigue⁷ in CFS patients.

Poor sleep quality can also result from underlying sleep disorders, such as obstructive sleep apnea (OSA) or insomnia⁸. These sleep disorders can disrupt the normal sleep pattern and lead to poor sleep quality and fatigue. 

A study published in the Journal of Clinical Sleep Medicine found that treating comorbid sleep disorders in individuals with CFS led to improvements in fatigue levels⁹. 

Therefore if you want to manage chronic fatigue, you have to address your sleep disorders.

Addressing poor sleep quality is crucial in managing chronic fatigue. 

Cognitive-behavioral therapy for insomnia (CBT-I)¹⁰ is a highly effective intervention for improving sleep quality and reducing fatigue in individuals with CFS. 

You can also practice good sleep hygiene by sleeping in a cool room and turning off your phone, TV, or any gadgets at least an hour before bedtime to help improve the quality of your sleep.

Low NAD Levels

One often overlooked factor is the role of nicotinamide adenine dinucleotide (NAD) levels in the body.

NAD is a coenzyme found in every cell of the body and plays a crucial role in energy production. It helps convert the food we eat into the energy our cells need to function properly. 

When NAD levels are low, our cells may not have enough energy to perform their essential functions, leading to fatigue and other health issues.

Optimizing NAD levels can help improve chronic fatigue in several ways. 

How NAD Can Improve Chronic Fatigue

First, NAD helps regulate the body’s circadian rhythm, which is crucial for healthy sleep patterns.¹¹ By supporting NAD levels, individuals may experience improved sleep quality, which can reduce fatigue.

Second, NAD is involved in repairing damaged DNA and maintaining the health of our cells¹². By optimizing NAD levels, individuals may experience improved cellular function, which can lead to increased energy levels and reduced fatigue.

Third, and most importantly, NAD plays a vital role in mitochondrial function.¹³ 

Mitochondria are often referred to as the powerhouse of the cell, as they are responsible for producing ATP, the primary source of energy for the body. 

When NAD levels are low, mitochondrial function can be compromised, leading to decreased energy production and increased fatigue.

In conclusion, chronic fatigue is a complex condition with various contributing factors. 

While stress and poor sleep quality are commonly recognized causes, low NAD levels can also play a significant role. 

By optimizing NAD levels through lifestyle changes and supplementation, you may experience improvements in your energy levels and overall quality of life.

Two Steps to Manage Chronic Fatigue

Step 1: Order the Intracellular NAD test today.

Order the Intracellular NAD test today and use it as soon as it arrives. This test can help you determine if you are deficient in NAD, assess the effectiveness of your NAD supplement, and find the optimal dosage for your needs.

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Step 2: Take Vitality ↑® NAD+ Booster

When it comes to boosting your energy levels, there’s nothing quite like Vitality ↑® NAD+ Booster. 

This supplement is meticulously formulated to provide a potent blend of natural ingredients that work synergistically to enhance your vitality and combat chronic fatigue. 

It is a clinically validated formulation consisting of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work synergistically to help:

• Manage fatigue
• Boost energy and improve performance
• Improve sleep quality
• Support inflammation, muscle, and joint pains
• Support healthy allergic and asthmatic symptoms
• Improve mental clarity and dementia symptoms
• Support functions of many organs (liver, kidney, heart, thyroid, fertility)…

But don’t just take our word for it. See how Vitality ↑® NAD+ Booster improved Melissa’s chronic fatigue issues.

I started using this product about 3 weeks ago and I can honestly say that by week 2 the need for a Power Nap daily has decreased, my energy level has increased, and I am exercising more.

Chronic fatigue has been a negative factor in my life since my early 40s so I was willing to give this a try. So far I’m very pleased and I’m only taking 1 scoop a day! Give this product a try 

~Melissa

Vitality ↑® NAD+ Booster supports healthy NAD levels to revitalize your cells, optimize your mitochondria, and improve your energy so you can do things you love!

Whether you’re feeling fatigued from a busy lifestyle or struggling with chronic fatigue syndrome, 

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If you want to manage your chronic fatigue and boost your energy…

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Our Money-Back Guarantee

If our Vitality ↑® NAD+ Booster fails to increase your NAD levels, just send us a message within 60 days and we will gladly refund your supplement purchase. 

Please note that tests are non-refundable.

Referenced Sources:

1. https://www.cdc.gov/me-cfs/index.html ↩︎
2. https://www.cdc.gov/mmwr/volumes/72/wr/mm7245a7.htm ↩︎
3. https://pubmed.ncbi.nlm.nih.gov/15036250/ ↩︎
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600319/ ↩︎
5. https://pubmed.ncbi.nlm.nih.gov/12700181/ ↩︎
6. https://pubmed.ncbi.nlm.nih.gov/23046847/ ↩︎
7. https://pubmed.ncbi.nlm.nih.gov/22972835/ ↩︎
8. https://www.ncbi.nlm.nih.gov/books/NBK547676/ ↩︎
9. https://www.sciencedirect.com/science/article/pii/S002239991400422X ↩︎
10. https://www.sleepfoundation.org/insomnia/treatment/cognitive-behavioral-therapy-insomnia ↩︎
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665902/ ↩︎
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973386/ ↩︎
13. https://pubmed.ncbi.nlm.nih.gov/25308486/ ↩︎